cmasa cytidine monophosphate N-acetylneuraminic acid synthetase a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cmasaprovided by ZNC
Official Full Name: cytidine monophosphate N-acetylneuraminic acid synthetase aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050420-277
See related: Ensembl:ENSDARG00000057334 AllianceGenome:ZFIN:ZDB-GENE-050420-277
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cmas; cmas1; wu:fj16c12; zgc:136241; si:dkey-183c2.1
Summary: Enables N-acylneuraminate cytidylyltransferase activity. Predicted to be involved in N-acetylneuraminate metabolic process. Located in nucleus. Is expressed in several structures, including axial mesoderm; central nervous system; liver; notochord; and pleuroperitoneal region. Orthologous to human CMAS (cytidine monophosphate N-acetylneuraminic acid synthetase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (14727027..14736597)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (14728238..14737842)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We show that the two cmas genes most likely originated from the third whole genome duplication, which occurred at the base of teleost radiation.
Title: Identification and biochemical characterization of two functional CMP-sialic acid synthetases in Danio rerio.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables N-acylneuraminate cytidylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acylneuraminate cytidylyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables N-acylneuraminate cytidylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-acetylneuraminate metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: N-acylneuraminate cytidylyltransferase A

Names: CMP-sialic acid synthetase 1; cytidine monophosphate sialic acid synthetase 1

NP_001035342.2

EC 2.7.7.43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040252.2 → NP_001035342.2 N-acylneuraminate cytidylyltransferase A

See identical proteins and their annotated locations for NP_001035342.2

Status: VALIDATED

Source sequence(s)

BC163617, EB871957, EH459296

UniProtKB/Swiss-Prot

B3DJV3, Q0E671, Q1RMB6

UniProtKB/TrEMBL

A0A8M9QB92

Related

ENSDARP00000134059.2, ENSDART00000158094.2

Conserved Domains (2) summary

cd02513
Location:30 → 245

CMP-NeuAc_Synthase; CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety

cl21460
Location:261 → 407

HAD_like; Haloacid Dehalogenase-like Hydrolases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007115.7 Reference GRCz11 Primary Assembly

Range

14727027..14736597

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001030151.2: Suppressed sequence

Description

NM_001030151.2: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.