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    tapas tapas [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37304, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tapasprovided by FlyBase
    Official Full Name
    tapasprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027529
    Locus tag
    Dmel_CG8920
    See related
    AllianceGenome:FB:FBgn0027529
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD21403; CG8920; Dmel\CG8920; tap; Tapas; TDRD7
    Summary
    Involved in piRNA-mediated retrotransposon silencing by mRNA destabilization and secondary piRNA processing. Located in P granule and perinuclear region of cytoplasm. Is expressed in several structures, including adult brain cell body rind; adult optic lobe; egg chamber; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in cataract 36. Orthologous to human TDRD7 (tudor domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tapas in Genome Data Viewer
    Location:
    56F16-56F16; 2-90 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20319180..20325973)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16206685..16213478)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44642 Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 8 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The LOTUS domain is a conserved DEAD-box RNA helicase regulator essential for the recruitment of Vasa to the germ plasm and nuage. Jeske M, et al. Genes Dev, 2017 May 1. PMID 28536148, Free PMC Article
    2. The Tudor domain protein Tapas, a homolog of the vertebrate Tdrd7, functions in the piRNA pathway to regulate retrotransposons in germline of Drosophila melanogaster. Patil VS, et al. BMC Biol, 2014 Oct 6. PMID 25287931, Free PMC Article
    3. Silencing of Transposable Elements by piRNAs in Drosophila: An Evolutionary Perspective. Luo S, et al. Genomics Proteomics Bioinformatics, 2017 Jun. PMID 28602845, Free PMC Article
    4. Global identification of bursicon-regulated genes in Drosophila melanogaster. An S, et al. BMC Genomics, 2008 Sep 18. PMID 18801173, Free PMC Article
    5. Conservation of an RNA regulatory map between Drosophila and mammals. Brooks AN, et al. Genome Res, 2011 Feb. PMID 20921232, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in secondary piRNA processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in secondary piRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transposable element silencing by piRNA-mediated mRNA destabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tapas
    Names
    CG8920-PA
    CG8920-PB
    CG8920-PD
    CG8920-PF
    tapas-PA
    tapas-PB
    tapas-PD
    tapas-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20319180..20325973
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137631.7 → NP_611475.3  tapas, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611475.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E910
      Conserved Domains (3) summary
      cd04508
      Location:1087 → 1131
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd09972
      Location:7 → 92
      LOTUS_TDRD_OSKAR; The first LOTUS domain in Oskar and Tudor-containing proteins 5 and 7
      pfam00567
      Location:1032 → 1151
      TUDOR; Tudor domain

    2. NM_001169742.2 → NP_001163213.1  tapas, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163213.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JGN5, Q6AWL6
      Conserved Domains (2) summary
      cd09972
      Location:7 → 92
      LOTUS_TDRD_OSKAR; The first LOTUS domain in Oskar and Tudor-containing proteins 5 and 7
      pfam00567
      Location:563 → 673
      TUDOR; Tudor domain

    3. NM_137630.4 → NP_611474.1  tapas, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611474.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AWL6, Q7KN83
      Related
      FBpp0085593
      Conserved Domains (1) summary
      pfam00567
      Location:477 → 587
      TUDOR; Tudor domain

    4. NM_153771.4 → NP_722455.3  tapas, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722455.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5AEP3
      Conserved Domains (2) summary
      cd04508
      Location:1001 → 1045
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:946 → 1065
      TUDOR; Tudor domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D5AEP3 D5AEP3
    E1JGN5 E1JGN5
    Q0E910 Q0E910
    Q7KN83 Q7KN83
    Q95SJ5 Q95SJ5

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