sm smooth [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: smprovided by FlyBase
Official Full Name: smoothprovided by FlyBase
Primary source: FLYBASE:FBgn0003435
Locus tag: Dmel_CG9218
See related: AllianceGenome:FB:FBgn0003435
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GH10856; CG9218; Dmel\CG9218; l(2)05338; Sm; smo
Summary: Predicted to enable mRNA binding activity. Involved in adult feeding behavior; axon guidance; and determination of adult lifespan. Located in nucleoplasm. Is expressed in several structures, including Y chromosome loop; adult brain cell body rind; adult head; ganglia; and larval nervous system. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and systemic scleroderma. Orthologous to several human genes including HNRNPLL (heterogeneous nuclear ribonucleoprotein L like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 56D15-56E1; 2-90 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (19517864..19631508, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (15405369..15519013, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Disruption of the smooth/CG9218 locus leads to age-dependent muscle degeneration, and motor dysfunction.
Title: The evolutionarily conserved RNA binding protein SMOOTH is essential for maintaining normal muscle function.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in adult feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of RNA splicing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleoplasm	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: smooth

Names: CG9218-PA; CG9218-PAA; CG9218-PAB; CG9218-PAC; CG9218-PB; CG9218-PE; CG9218-PG; CG9218-PH; CG9218-PI; CG9218-PJ; CG9218-PK; CG9218-PL; CG9218-PM; CG9218-PO; CG9218-PP; CG9218-PT; CG9218-PU; CG9218-PV; CG9218-PW; CG9218-PY; CG9218-PZ; sm-PA; sm-PAA; sm-PAB; sm-PAC; sm-PB; sm-PE; sm-PG; sm-PH; sm-PI; sm-PJ; sm-PK; sm-PL; sm-PM; sm-PO; sm-PP; sm-PT; sm-PU; sm-PV; sm-PW; sm-PY; sm-PZ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

19517864..19631508 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001259505.2 → NP_001246434.1 smooth, isoform AA [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246434.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K8A2

Conserved Domains (3) summary

cd12424
Location:275 → 346

RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12427
Location:393 → 475

RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12694
Location:75 → 160

RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
NM_001259497.2 → NP_001246426.1 smooth, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246426.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K852

Conserved Domains (3) summary

cd12424
Location:264 → 335

RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12427
Location:382 → 464

RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12694
Location:80 → 165

RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
NM_001259500.2 → NP_001246429.1 smooth, isoform U [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246429.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K8A1

Conserved Domains (3) summary

cd12424
Location:282 → 353

RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12427
Location:400 → 482

RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12694
Location:75 → 160

RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
NM_001274164.1 → NP_001261093.1 smooth, isoform AB [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261093.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KF04

Conserved Domains (3) summary

cd12424
Location:276 → 347

RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12427
Location:394 → 476

RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12694
Location:80 → 165

RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
NM_001259498.2 → NP_001246427.1 smooth, isoform O [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246427.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7B0

Conserved Domains (3) summary

cd12424
Location:263 → 334

RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12427
Location:381 → 461

RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12694
Location:80 → 165

RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
NM_001259495.2 → NP_001246424.1 smooth, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246424.1

Status: REVIEWED

UniProtKB/TrEMBL

D5AEJ9

Conserved Domains (2) summary

cd12424
Location:231 → 302

RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12427
Location:349 → 431

RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
NM_166368.5 → NP_725913.2 smooth, isoform P [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725913.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0C4DHD5

Conserved Domains (3) summary

cd12424
Location:201 → 272

RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12427
Location:319 → 401

RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cl17169
Location:51 → 119

RRM_SF; RNA recognition motif (RRM) superfamily
NM_057383.7 → NP_476731.1 smooth, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476731.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JMZ7

Related

FBpp0085681

Conserved Domains (3) summary

cd12424
Location:242 → 313

RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12427
Location:360 → 442

RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12694
Location:80 → 165

RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
NM_001259494.2 → NP_001246423.1 smooth, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246423.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7H8

Conserved Domains (3) summary

cd12424
Location:302 → 373

RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12427
Location:420 → 502

RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12694
Location:80 → 165

RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
NM_001259496.2 → NP_001246425.1 smooth, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246425.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7W3

Conserved Domains (3) summary

cd12424
Location:259 → 330

RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12427
Location:377 → 459

RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12694
Location:80 → 165

RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
NM_001259499.2 → NP_001246428.1 smooth, isoform T [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246428.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7I2

Conserved Domains (3) summary

cd12424
Location:319 → 390

RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12427
Location:437 → 519

RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12694
Location:80 → 165

RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
NM_001032268.3 → NP_001027439.2 smooth, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027439.2

Status: REVIEWED

UniProtKB/TrEMBL

Q6NND8

Conserved Domains (3) summary

cd12424
Location:247 → 318

RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12427
Location:365 → 447

RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12694
Location:80 → 165

RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
NM_001259501.2 → NP_001246430.1 smooth, isoform V [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246430.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7W7

Conserved Domains (3) summary

cd12424
Location:307 → 378

RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12427
Location:425 → 507

RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12694
Location:80 → 165

RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
NM_001032269.3 → NP_001027440.1 smooth, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027440.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JMZ7

Conserved Domains (3) summary

cd12424
Location:242 → 313

RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12427
Location:360 → 442

RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12694
Location:80 → 165

RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
NM_001259504.2 → NP_001246433.1 smooth, isoform Z [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246433.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7I6

Conserved Domains (3) summary

cd12424
Location:258 → 329

RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12427
Location:376 → 458

RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12694
Location:80 → 165

RRM2_hnRNPL_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
NM_001259502.2 → NP_001246431.1 smooth, isoform W [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246431.1

Status: REVIEWED

UniProtKB/TrEMBL

Q0E914

Conserved Domains (2) summary

cd12424
Location:27 → 98

RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12427
Location:145 → 227

RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
NM_001043096.2 → NP_001036561.1 smooth, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036561.1

Status: REVIEWED

UniProtKB/TrEMBL

Q0E914

Conserved Domains (2) summary

cd12424
Location:27 → 98

RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12427
Location:145 → 227

RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
NM_001259503.2 → NP_001246432.1 smooth, isoform Y [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246432.1

Status: REVIEWED

UniProtKB/TrEMBL

Q0E914

Conserved Domains (2) summary

cd12424
Location:27 → 98

RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12427
Location:145 → 227

RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
NM_001274165.1 → NP_001261094.1 smooth, isoform AC [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261094.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KEV0

Conserved Domains (2) summary

cd12424
Location:68 → 139

RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12427
Location:186 → 268

RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
NM_166369.5 → NP_725914.1 smooth, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725914.1

Status: REVIEWED

UniProtKB/TrEMBL

A1ZBN3

Related

FBpp0085684

Conserved Domains (2) summary

cd12424
Location:171 → 242

RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12427
Location:289 → 371

RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins
NM_166370.5 → NP_725915.2 smooth, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725915.2

Status: REVIEWED

UniProtKB/TrEMBL

A1ZBN4, Q8IHH3

Conserved Domains (2) summary

cd12424
Location:187 → 258

RRM3_hnRNPL_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

cd12427
Location:305 → 387

RRM4_hnRNPL_like; RNA recognition motif 4 in heterogeneous nuclear ribonucleoprotein L (hnRNP-L) and similar proteins

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4K7B0		A0A0B4K7B0
A0A0B4K7H8		A0A0B4K7H8
A0A0B4K7I2		A0A0B4K7I2
A0A0B4K7I6		A0A0B4K7I6
A0A0B4K7W3		A0A0B4K7W3
A0A0B4K7W7		A0A0B4K7W7
A0A0B4K852		A0A0B4K852
A0A0B4K8A1		A0A0B4K8A1
A0A0B4K8A2		A0A0B4K8A2
A0A0B4KEV0		A0A0B4KEV0
A0A0B4KF04		A0A0B4KF04
A0A0C4DHD5		A0A0C4DHD5
A1ZBN3		A1ZBN3
D5AEJ9		D5AEJ9
Q0E914		Q0E914
Q6NND8		Q6NND8
Q7JMZ7		Q7JMZ7
Q86P89		Q86P89
Q8IHH3		Q8IHH3
Q8SXP5		Q8SXP5