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    faf fat facets [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43749, updated on 17-Dec-2024

    Summary

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    Official Symbol
    fafprovided by FlyBase
    Official Full Name
    fat facetsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0005632
    Locus tag
    Dmel_CG1945
    See related
    AllianceGenome:FB:FBgn0005632
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA.LD22582; BcDNA:LD22582; CG1945; Dmel\CG1945; Faf; FAF; Fat; P55824; USPX
    Summary
    Enables cysteine-type deubiquitinase activity. Involved in several processes, including mystery cell differentiation; nuclear cortical migration; and positive regulation of BMP signaling pathway. Located in cytoplasm. Is expressed in several structures, including adult head; female germline cell; ganglia; gonad; and imaginal disc. Human ortholog(s) of this gene implicated in Y-linked spermatogenic failure 2; female-restricted syndromic X-linked intellectual disability 99; and non-syndromic X-linked intellectual disability 99. Orthologous to human USP9X (ubiquitin specific peptidase 9 X-linked) and USP9Y (ubiquitin specific peptidase 9 Y-linked). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See faf in Genome Data Viewer
    Location:
    100D2-100D2; 3-102 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31777020..31790681)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27602742..27616403)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR33945 Neighboring gene beta glucuronidase Neighboring gene septin interacting protein 3 Neighboring gene uncharacterized protein Neighboring gene Methylcrotonoyl-CoA carboxylase 1 Neighboring gene ATP-dependent chromatin assembly factor large subunit Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 100a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein degradation: de-ubiquitinate to decide your fate. Kalderon D. Curr Biol, 1996 Jun 1. PMID 8793288
    2. Deubiquitinases in Neurodegeneration. Bello AI, et al. Cells, 2022 Feb 5. PMID 35159365, Free PMC Article
    3. La FAM fatale: USP9X in development and disease. Murtaza M, et al. Cell Mol Life Sci, 2015 Jun. PMID 25672900, Free PMC Article
    4. The fat facets gene is required for Drosophila eye and embryo development. Fischer-Vize JA, et al. Development, 1992 Dec. PMID 1295747
    5. Deubiquitinating enzymes: their diversity and emerging roles. Chung CH, et al. Biochem Biophys Res Commun, 1999 Dec 29. PMID 10603300

    See all (161) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate that the ability of faf, hiw or Rdl to modulate sleep and protect against cognitive impairments during waking is circuit dependent. Decreasing hiw and Rdl within the Mushroom Bodies protects against the negative effects of sleep deprivation as indicated by the absence of a subsequent homeostatic response, or deficits in short-term memory.
      Title: Identification of Genes that Maintain Behavioral and Structural Plasticity during Sleep Loss.
    2. Faf inhibits the IMD pathway by modulating the state of Imd ubiquitination and/or stability.
      Title: fat facets induces polyubiquitination of Imd and inhibits the innate immune response in Drosophila.
    3. Fat facets deubiquitylation of Medea/Smad4 modulates interpretation of a Dpp morphogen gradient
      Title: Fat facets deubiquitylation of Medea/Smad4 modulates interpretation of a Dpp morphogen gradient.
    4. By deubiquitinating Lqf, which enhances the efficiency of Delta internalization, Faf stimulates Delta signaling
      Title: Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellularization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium HMP PubMed 
    involved_in dorsal/ventral axis specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell migration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mystery cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of innate immune response HMP PubMed 
    involved_in nuclear cortical migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fat facets
    Names
    CG1945-PA
    CG1945-PC
    CG1945-PD
    CG1945-PE
    CG1945-PG
    CG1945-PH
    CG1945-PI
    Fat facets
    Fat-Facets
    faf-PA
    faf-PC
    faf-PD
    faf-PE
    faf-PG
    faf-PH
    faf-PI
    NP_001247387.1
    NP_001247388.1
    NP_001247389.2
    NP_001247390.1
    NP_001287627.1
    NP_524612.2
    NP_733455.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31777020..31790681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260460.2 → NP_001247389.2  fat facets, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247389.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6W2
      Conserved Domains (2) summary
      cd02659
      Location:1666 → 2064
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:1668 → 2059
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. NM_079873.5 → NP_524612.2  fat facets, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524612.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P55824, Q9V9T6, Q9Y0Z7
      Related
      FBpp0085202
      Conserved Domains (2) summary
      cd02659
      Location:1666 → 2064
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:1668 → 2059
      UCH; Ubiquitin carboxyl-terminal hydrolase

    3. NM_001300698.1 → NP_001287627.1  fat facets, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287627.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7S0
      Conserved Domains (2) summary
      cd02659
      Location:1666 → 2064
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:1668 → 2059
      UCH; Ubiquitin carboxyl-terminal hydrolase

    4. NM_170576.3 → NP_733455.1  fat facets, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733455.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P55824
      Related
      FBpp0085203
      Conserved Domains (2) summary
      cd02659
      Location:1666 → 2064
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:1668 → 2059
      UCH; Ubiquitin carboxyl-terminal hydrolase

    5. NM_001260459.1 → NP_001247388.1  fat facets, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247388.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6W2
      Conserved Domains (2) summary
      cd02659
      Location:1666 → 2064
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:1668 → 2059
      UCH; Ubiquitin carboxyl-terminal hydrolase

    6. NM_001260461.1 → NP_001247390.1  fat facets, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247390.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7S0
      Conserved Domains (2) summary
      cd02659
      Location:1666 → 2064
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:1668 → 2059
      UCH; Ubiquitin carboxyl-terminal hydrolase

    7. NM_001260458.1 → NP_001247387.1  fat facets, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247387.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7S0
      Conserved Domains (2) summary
      cd02659
      Location:1666 → 2064
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:1668 → 2059
      UCH; Ubiquitin carboxyl-terminal hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6W2 A0A0B4K6W2
    A0A0B4K7S0 A0A0B4K7S0
    P55824.2 P55824

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