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    mld molting defective [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768685, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mldprovided by FlyBase
    Official Full Name
    molting defectiveprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263490
    Locus tag
    Dmel_CG34100
    See related
    AllianceGenome:FB:FBgn0263490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13620; CG31312; CG33343; CG34100; CG9469; Dmel\CG34100; DTS-3; l(3)3[DTS]; L(3)3[DTS]; l(3)DTS3; Mld
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; ecdysone biosynthetic process; and long-term memory. Located in nucleus. Is expressed in several structures, including antennal anlage; antennal primordium; epidermis; germline cell; and head epidermis primordium. Orthologous to several human genes including ZNF107 (zinc finger protein 107); ZNF208 (zinc finger protein 208); and ZNF473 (zinc finger protein 473). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mld in Genome Data Viewer
    Location:
    96A9-96A12; 3-85 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24585653..24623899)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20411375..20449621)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Repressed by TOR Neighboring gene long non-coding RNA:CR46094 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46095 Neighboring gene Syntaxin 18 Neighboring gene atlastin Neighboring gene wsck Neighboring gene Metallothionein F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The steroid molting hormone Ecdysone regulates sleep in adult Drosophila melanogaster. Ishimoto H, et al. Genetics, 2010 May. PMID 20215472, Free PMC Article
    2. Postembryonic development of the midline glia in the CNS of Drosophila: proliferation, programmed cell death, and endocrine regulation. Awad TA, et al. Dev Biol, 1997 Jul 15. PMID 9242424
    3. Steroid control of longevity in Drosophila melanogaster. Simon AF, et al. Science, 2003 Feb 28. PMID 12610309
    4. Ecdysone signaling regulates the formation of long-term courtship memory in adult Drosophila melanogaster. Ishimoto H, et al. Proc Natl Acad Sci U S A, 2009 Apr 14. PMID 19342482, Free PMC Article
    5. Two distinct mechanisms silence chinmo in Drosophila neuroblasts and neuroepithelial cells to limit their self-renewal. Dillard C, et al. Development, 2018 Jan 25. PMID 29361557

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 24594690-24594874 mobile_element_type = transposon:pogo{}1417

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ecdysone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of circadian sleep/wake cycle, sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    molting defective
    Names
    CG34100-PA
    CG34100-PC
    CG34100-PD
    CG34100-PE
    CG34100-PF
    DTS-3
    defective
    dominant temperature-sensitive 3
    lethal (3) DTS3
    mld-PA
    mld-PC
    mld-PD
    mld-PE
    mld-PF
    molting

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24585653..24623899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260360.1 → NP_001247289.1  molting defective, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247289.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7S6, D2NUK2
      Conserved Domains (3) summary
      smart00868
      Location:186 → 255
      zf-AD; Zinc-finger associated domain (zf-AD)
      sd00017
      Location:1814 → 1834
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1839 → 1861
      zf-C2H2; Zinc finger, C2H2 type

    2. NM_001043289.2 → NP_001036754.1  molting defective, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036754.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2NUK2, Q0KI16, Q8IMW5
      Conserved Domains (2) summary
      smart00868
      Location:186 → 255
      zf-AD; Zinc-finger associated domain (zf-AD)
      sd00017
      Location:1756 → 1776
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001260359.1 → NP_001247288.1  molting defective, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247288.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6J3, D2NUK2
      Conserved Domains (3) summary
      smart00868
      Location:186 → 255
      zf-AD; Zinc-finger associated domain (zf-AD)
      sd00017
      Location:1734 → 1754
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1790 → 1812
      zf-C2H2; Zinc finger, C2H2 type

    4. NM_001043290.2 → NP_001036755.2  molting defective, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036755.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2NUK2, Q0KI16, Q8IMW5
      Conserved Domains (2) summary
      smart00868
      Location:186 → 255
      zf-AD; Zinc-finger associated domain (zf-AD)
      sd00017
      Location:1756 → 1776
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_143016.2 → NP_651273.2  molting defective, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651273.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4DHB7, D2NUK2
      Conserved Domains (3) summary
      smart00868
      Location:186 → 255
      zf-AD; Zinc-finger associated domain (zf-AD)
      sd00017
      Location:1792 → 1812
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1817 → 1839
      zf-C2H2; Zinc finger, C2H2 type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6J3 A0A0B4K6J3
    A0A0B4K7S6 A0A0B4K7S6
    A0A0C4DHB7 A0A0C4DHB7
    Q8IMW5 Q8IMW5
    Q8MSR6 Q8MSR6

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