sd scalloped [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sdprovided by FlyBase
Official Full Name: scallopedprovided by FlyBase
Primary source: FLYBASE:FBgn0003345
Locus tag: Dmel_CG8544
See related: AllianceGenome:FB:FBgn0003345
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Liang-2.14; CG8544; clone 2.14; Dmel\CG8544; DROEXO; DROEXO2; EP(X)1088; EP1088; l(1)G0239; l(1)G0262; l(1)G0309; l(1)G0315; l(1)G0483; l(1)HF394; l(1)III; Sd; SD; sp; TEAD
Summary: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coregulator binding activity. Involved in several processes, including imaginal disc-derived appendage morphogenesis; negative regulation of neuroblast proliferation; and regulation of DNA-templated transcription. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including ganglia; imaginal disc; myoblast; sense organ; and somatic muscle cell. Human ortholog(s) of this gene implicated in Sveinsson chorioretinal atrophy. Orthologous to several human genes including TEAD3 (TEA domain transcription factor 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 13F1-13F5; 1-52 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (15804370..15827682)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (15698403..15721714)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Biochemical properties of VGLL4 from Homo sapiens and Tgi from Drosophila melanogaster and possible biological implications.
Title: Biochemical properties of VGLL4 from Homo sapiens and Tgi from Drosophila melanogaster and possible biological implications.
Two central players in controlling Hippo-dependent gene expression are the TEAD transcription factor Scalloped (Sd) and its transcriptional co-activator Yorkie (Yki).
Title: Opposing transcriptional and post-transcriptional roles for Scalloped in binary Hippo-dependent neural fate decisions.
In this study, the authors identify Nerfin-1 as a transcriptional repressor that antagonizes the activity of the Sd-Yki complex by binding to the TEA DNA-binding domain of Sd. Consistent with its biochemical function, ectopic expression of Nerfin-1 results in tissue undergrowth in an Sd-dependent manner.
Title: Nerfin-1 represses transcriptional output of Hippo signaling in cell competition.
Scalloped (Sd) and Nervous fingers-1 (Nerfin-1) transcription factors physically and functionally interact to maintain medulla neuron fate in the Drosophila melanogaster central nervous system.
Title: The Scalloped and Nerfin-1 Transcription Factors Cooperate to Maintain Neuronal Cell Fate.
These findings suggest that spatiotemporal expression of transcription factor Sd induces differential growth regulation by Yki during wing disc development, highlighting coordination between Yki and CycE to control growth and maintain homeostasis.
Title: Differential Regulation of Cyclin E by Yorkie-Scalloped Signaling in Organ Development.
DNA-binding transcription factor Scalloped mediates both Yorkie overexpression and loss-of-function phenotypes yet is itself dispensable for normal eye development
Title: Validating upstream regulators of Yorkie activity in Hippo signaling through scalloped-based genetic epistasis.
found that human E2F1 competes with YAP for TEAD1 binding, affecting YAP activity, indicating that this mode of cross-regulation is conserved
Title: A Balance of Yki/Sd Activator and E2F1/Sd Repressor Complexes Controls Cell Survival and Affects Organ Size.
Data show that Yorkie (Yki) and Scalloped (Sd) are required for epidermal wound closure in the larval epidermis.
Title: Yorkie regulates epidermal wound healing in Drosophila larvae independently of cell proliferation and apoptosis.
Vestigial protein phosphorylation of serine 215 occurs in the nucleus and requires the presence of Scalloped.
Title: The activity of the Drosophila Vestigial protein is modified by Scalloped-dependent phosphorylation.
Data indicate that the TEAD family transcription factor Scalloped (Scalloped) regulates PDGF/VEGFR receptor (Pvr) expression.
Title: The TEAD family transcription factor Scalloped regulates blood progenitor maintenance and proliferation in Drosophila through PDGF/VEGFR receptor (Pvr) signaling.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	IEA Inferred from Electronic Annotation more info
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of neuroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in wing disc development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: scalloped

Names: CG8544-PA; CG8544-PB; CG8544-PC; CG8544-PD; CG8544-PE; CG8544-PF; CG8544-PG; CG8544-PH; CG8544-PI; CG8544-PJ; CG8544-PK; CG8544-PL; CG8544-PM; CG8544-PN; CG8544-PO; CG8544-PP; CG8544-PQ; CG8544-PR; CG8544-PS; CG8544-PT; CG8544-PU; CG8544-PV; sd-PA; sd-PB; sd-PC; sd-PD; sd-PE; sd-PF; sd-PG; sd-PH; sd-PI; sd-PJ; sd-PK; sd-PL; sd-PM; sd-PN; sd-PO; sd-PP; sd-PQ; sd-PR; sd-PS; sd-PT; sd-PU; sd-PV; spatula

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

15804370..15827682

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001316637.1 → NP_001303566.1 scalloped, isoform U [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A8JUY5, Q058U0

Conserved Domains (2) summary

smart00426
Location:63 → 130

TEA; TEA domain

pfam17725
Location:199 → 407

YBD; YAP binding domain
NM_001258767.2 → NP_001245696.1 scalloped, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245696.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JUY5, Q058U0

Conserved Domains (2) summary

smart00426
Location:63 → 130

TEA; TEA domain

pfam17725
Location:199 → 407

YBD; YAP binding domain
NM_001258772.2 → NP_001245701.1 scalloped, isoform O [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245701.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JUY5, Q058U0

Conserved Domains (2) summary

smart00426
Location:63 → 130

TEA; TEA domain

pfam17725
Location:199 → 407

YBD; YAP binding domain
NM_001258773.2 → NP_001245702.1 scalloped, isoform P [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245702.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JUY5, Q058U0

Conserved Domains (2) summary

smart00426
Location:63 → 130

TEA; TEA domain

pfam17725
Location:199 → 407

YBD; YAP binding domain
NM_001103519.3 → NP_001096989.1 scalloped, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001096989.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JUY5, Q058U0

Conserved Domains (2) summary

smart00426
Location:63 → 130

TEA; TEA domain

pfam17725
Location:199 → 407

YBD; YAP binding domain
NM_001258768.1 → NP_001245697.1 scalloped, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245697.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P30052, Q9VXN7

UniProtKB/TrEMBL

A8JUY9, F3YDC4

Conserved Domains (2) summary

smart00426
Location:88 → 155

TEA; TEA domain

pfam17725
Location:229 → 437

YBD; YAP binding domain
NM_001298370.1 → NP_001285299.1 scalloped, isoform T [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285299.1

Status: REVIEWED

UniProtKB/TrEMBL

F3YDC4, X2JFL9

Conserved Domains (2) summary

smart00426
Location:23 → 90

TEA; TEA domain

pfam17725
Location:164 → 372

YBD; YAP binding domain
NM_001382196.1 → NP_001368984.1 scalloped, isoform V [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A6H2EE76

Conserved Domains (2) summary

smart00426
Location:88 → 155

TEA; TEA domain

pfam17725
Location:224 → 432

YBD; YAP binding domain
NM_001258770.3 → NP_001245699.1 scalloped, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245699.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJ99, Q058U0

Conserved Domains (2) summary

smart00426
Location:88 → 155

TEA; TEA domain

pfam17725
Location:224 → 432

YBD; YAP binding domain
NM_001258771.3 → NP_001245700.1 scalloped, isoform N [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245700.1

Status: REVIEWED

UniProtKB/TrEMBL

Q058U0, Q8IR25

Conserved Domains (1) summary

smart00426
Location:23 → 90

TEA; TEA domain
NM_078614.5 → NP_511169.1 scalloped, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511169.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P30052, Q9VXN7

UniProtKB/TrEMBL

A8JUY9, F3YDC4

Related

FBpp0073914

Conserved Domains (2) summary

smart00426
Location:88 → 155

TEA; TEA domain

pfam17725
Location:229 → 437

YBD; YAP binding domain
NM_001103520.3 → NP_001096990.1 scalloped, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001096990.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P30052, Q9VXN7

UniProtKB/TrEMBL

A8JUY9, F3YDC4

Conserved Domains (2) summary

smart00426
Location:88 → 155

TEA; TEA domain

pfam17725
Location:229 → 437

YBD; YAP binding domain
NM_001169290.2 → NP_001162761.1 scalloped, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162761.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJ99, Q058U0

Conserved Domains (2) summary

smart00426
Location:88 → 155

TEA; TEA domain

pfam17725
Location:224 → 432

YBD; YAP binding domain
NM_001103522.3 → NP_001096992.1 scalloped, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001096992.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P30052, Q9VXN7

UniProtKB/TrEMBL

A8JUY9, F3YDC4

Conserved Domains (2) summary

smart00426
Location:88 → 155

TEA; TEA domain

pfam17725
Location:229 → 437

YBD; YAP binding domain
NM_167465.3 → NP_727900.1 scalloped, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727900.1

Status: REVIEWED

UniProtKB/TrEMBL

Q058U0, Q8IR25

Related

FBpp0073915

Conserved Domains (1) summary

smart00426
Location:23 → 90

TEA; TEA domain
NM_001169291.2 → NP_001162762.1 scalloped, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162762.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJ99, Q058U0

Conserved Domains (2) summary

smart00426
Location:88 → 155

TEA; TEA domain

pfam17725
Location:224 → 432

YBD; YAP binding domain
NM_001103521.3 → NP_001096991.1 scalloped, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001096991.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P30052, Q9VXN7

UniProtKB/TrEMBL

A8JUY9, F3YDC4

Conserved Domains (2) summary

smart00426
Location:88 → 155

TEA; TEA domain

pfam17725
Location:229 → 437

YBD; YAP binding domain
NM_001272654.2 → NP_001259583.1 scalloped, isoform S [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259583.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P30052, Q9VXN7

UniProtKB/TrEMBL

A8JUY9, F3YDC4

Conserved Domains (2) summary

smart00426
Location:88 → 155

TEA; TEA domain

pfam17725
Location:229 → 437

YBD; YAP binding domain
NM_001272653.2 → NP_001259582.1 scalloped, isoform R [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259582.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P30052, Q9VXN7

UniProtKB/TrEMBL

A8JUY9, F3YDC4

Conserved Domains (2) summary

smart00426
Location:88 → 155

TEA; TEA domain

pfam17725
Location:229 → 437

YBD; YAP binding domain
NM_001258769.2 → NP_001245698.1 scalloped, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245698.1

Status: REVIEWED

UniProtKB/TrEMBL

Q058U0, Q8IR25

Conserved Domains (1) summary

smart00426
Location:23 → 90

TEA; TEA domain
NM_001272652.1 → NP_001259581.1 scalloped, isoform Q [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259581.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PH78

Conserved Domains (1) summary

smart00426
Location:23 → 90

TEA; TEA domain
NM_206727.3 → NP_996450.1 scalloped, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996450.1

Status: REVIEWED

UniProtKB/TrEMBL

Q058U0, Q8IR25

Conserved Domains (1) summary

smart00426
Location:23 → 90

TEA; TEA domain

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A6H2EE76		A0A6H2EE76
A8JUY5		A8JUY5
A8JUY9		A8JUY9
E1JJ99		E1JJ99
M9PH78		M9PH78
P30052.1		P30052
Q8IR25		Q8IR25
Q8SZ20		Q8SZ20
X2JFL9		X2JFL9