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    rux roughex [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31535, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ruxprovided by FlyBase
    Official Full Name
    roughexprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003302
    Locus tag
    Dmel_CG4336
    See related
    AllianceGenome:FB:FBgn0003302
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4336; Dmel\CG4336; Rux
    Summary
    Involved in mitotic cell cycle and regulation of cell cycle. Located in nucleus. Is expressed in several structures, including central brain primordium; embryonic central brain neurons; ganglia; larval nervous system; and lateral cord. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rux in Genome Data Viewer
    Location:
    5D2-5D2; 1-15 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6035753..6037800, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5929786..5931833, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene mab-21 Neighboring gene long non-coding RNA:CR44499 Neighboring gene Malignant T cell amplified sequence 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulated protein depletion by the auxin-inducible degradation system in Drosophila melanogaster. Trost M, et al. Fly (Austin), 2016 Jan 2. PMID 27010248, Free PMC Article
    2. Sister chromatids fail to separate during an induced endoreplication cycle in Drosophila embryos. Vidwans SJ, et al. Curr Biol, 2002 May 14. PMID 12015119, Free PMC Article
    3. The cyclin-dependent kinase inhibitor Roughex is involved in mitotic exit in Drosophila. Foley E, et al. Curr Biol, 2001 Feb 6. PMID 11231149
    4. S-phase function of Drosophila cyclin A and its downregulation in G1 phase. Sprenger F, et al. Curr Biol, 1997 Jul 1. PMID 9210381, Free PMC Article
    5. Recurrent events of positive selection in independent Drosophila lineages at the spermatogenesis gene roughex. Llopart A, et al. Genetics, 2008 Jun. PMID 18505872, Free PMC Article

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. amino acid replacements have contributed disproportionately to divergence, consistent with adaptive evolution at the Rux protein
      Title: Recurrent events of positive selection in independent Drosophila lineages at the spermatogenesis gene roughex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of exit from mitosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    roughex
    Names
    CG4336-PA
    CG4336-PB
    Rough-ex
    rux-PA
    rux-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6035753..6037800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258611.1 → NP_001245540.1  roughex, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245540.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P50445, Q540W5, Q9W446
      UniProtKB/TrEMBL
      B3U0S0, M9NDP7
      Conserved Domains (1) summary
      pfam06020
      Location:10 → 335
      Roughex; Drosophila roughex protein

    2. NM_078498.4 → NP_511053.2  roughex, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511053.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P50445, Q540W5, Q9W446
      UniProtKB/TrEMBL
      B3U0S0, M9NDP7
      Related
      FBpp0070854
      Conserved Domains (1) summary
      pfam06020
      Location:10 → 335
      Roughex; Drosophila roughex protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NDP7 M9NDP7
    P50445.2 P50445

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