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    CG3556 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31380, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG3556provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029708
    Locus tag
    Dmel_CG3556
    See related
    AllianceGenome:FB:FBgn0029708
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG3556
    Summary
    Predicted to enable cobalamin binding activity. Predicted to be involved in cobalamin transport. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in congenital intrinsic factor deficiency and pernicious anemia. Orthologous to human CBLIF (cobalamin binding intrinsic factor) and TCN1 (transcobalamin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3556 in Genome Data Viewer
    Location:
    4C7-4C7; 1-8 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4530231..4535464)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4424264..4429497)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43614 Neighboring gene long non-coding RNA:CR46499 Neighboring gene long non-coding RNA:CR32773 Neighboring gene bifid Neighboring gene CHOp24 Neighboring gene ruby

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enhancer trap infidelity in Drosophila optomotor-blind. Mayer LR, et al. Fly (Austin), 2013 Apr-Jun. PMID 23519069, Free PMC Article
    2. The Dm-Myb Oncoprotein Contributes to Insulator Function and Stabilizes Repressive H3K27me3 PcG Domains. Santana JF, et al. Cell Rep, 2020 Mar 10. PMID 32160531, Free PMC Article
    3. RNA editing in Drosophila melanogaster: New targets and functional consequences. Stapleton M, et al. RNA, 2006 Nov. PMID 17018572, Free PMC Article
    4. Seizure control through genetic and pharmacological manipulation of Pumilio in Drosophila: a key component of neuronal homeostasis. Lin WH, et al. Dis Model Mech, 2017 Feb 1. PMID 28067623, Free PMC Article
    5. Tissue-specific (ts)CRISPR as an efficient strategy for in vivo screening in Drosophila. Meltzer H, et al. Nat Commun, 2019 May 8. PMID 31068592, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cobalamin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cobalamin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cobalamin transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cobalamin transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3556-PA
    CG3556-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      4530231..4535464
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258600.2 → NP_001245529.1  uncharacterized protein Dmel_CG3556, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245529.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RJ69, Q8T0N7, Q9W4K2
      UniProtKB/TrEMBL
      M9NGQ5
      Conserved Domains (1) summary
      cl08267
      Location:165 → 411
      ISOPREN_C2_like; This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate ...

    2. NM_131936.3 → NP_572164.2  uncharacterized protein Dmel_CG3556, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572164.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RJ69, Q8T0N7, Q9W4K2
      UniProtKB/TrEMBL
      M9NGQ5
      Related
      FBpp0070642
      Conserved Domains (1) summary
      cl08267
      Location:165 → 411
      ISOPREN_C2_like; This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NGQ5 M9NGQ5
    Q9W4K2.1 Q9W4K2

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