gig2i grass carp reovirus (GCRV)-induced gene 2i [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gig2iprovided by ZNC
Official Full Name: grass carp reovirus (GCRV)-induced gene 2iprovided by ZNC
Primary source: ZFIN:ZDB-GENE-120409-1
See related: Ensembl:ENSDARG00000099325 AllianceGenome:ZFIN:ZDB-GENE-120409-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: irig
Summary: Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity. Acts upstream of or within defense response to virus. Located in cytoplasm. Is expressed in several structures, including eye; gill; heart; liver; and pleuroperitoneal region. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 21

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (22672794..22673758, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (22636189..22637153, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cloning of zebrafish Gig2 homolog (named Danio rerio Gig2-I, DreI), and characterization of its antiviral role and expressional regulation signaling pathway.
Title: Identification of DreI as an antiviral factor regulated by RLR signaling pathway.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables NAD+-protein poly-ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to virus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: grass carp reovirus (GCRV)-induced gene 2i

Names: DreI; Drel; Gig2 Drel; Gig2-I; Gig2-like protein DreI; gig2l; interferon responsive immune

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001258225.1 → NP_001245154.1 grass carp reovirus (GCRV)-induced gene 2i

See identical proteins and their annotated locations for NP_001245154.1

Status: PROVISIONAL

Source sequence(s)

HQ269376

UniProtKB/TrEMBL

A0A2R8QQ89, E7F7D7

Related

ENSDARP00000137912.1, ENSDART00000164910.2

Conserved Domains (1) summary

cl00283
Location:30 → 101

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...