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    WWP2 WW domain containing E3 ubiquitin protein ligase 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 705464, updated on 17-Aug-2024

    Summary

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    Official Symbol
    WWP2provided by VGNC
    Official Full Name
    WW domain containing E3 ubiquitin protein ligase 2provided by VGNC
    Primary source
    VGNC:VGNC:103887
    Locus tag
    EGK_12946
    See related
    Ensembl:ENSMMUG00000003339
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See WWP2 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 20 NC_041773.1 (57020233..57203105)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 20 NC_027912.1 (54200307..54384085)

    Chromosome 20 - NC_041773.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114674285 Neighboring gene NIN1 (RPN12) binding protein 1 homolog Neighboring gene protein-L-isoaspartate(D-aspartate) O-methyltransferase Neighboring gene microRNA mir-140 Neighboring gene uncharacterized LOC106995077 Neighboring gene proteasome 26S subunit, non-ATPase 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein K63-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NEDD4-like E3 ubiquitin-protein ligase WWP2
    NP_001254530.1
    XP_014981907.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267601.2 → NP_001254530.1  NEDD4-like E3 ubiquitin-protein ligase WWP2

      See identical proteins and their annotated locations for NP_001254530.1

      Status: PROVISIONAL

      Source sequence(s)
      JN712747
      UniProtKB/TrEMBL
      A0A8J8XF87, F6RWN6, H9ERH0, I3RSH1
      Related
      ENSMMUP00000004450.4, ENSMMUT00000004721.4
      Conserved Domains (5) summary
      cd04021
      Location:17 → 142
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      smart00119
      Location:539 → 867
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:516 → 868
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:447 → 477
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:332 → 361
      WW; WW domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041773.1 Reference Mmul_10 Primary Assembly

      Range
      57020233..57203105
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015126421.2 → XP_014981907.2  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1

      UniProtKB/TrEMBL
      F7EGU5
      Conserved Domains (6) summary
      cd04021
      Location:17 → 142
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      smart00456
      Location:406 → 436
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:612 → 940
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      PHA03247
      Location:163 → 312
      PHA03247; large tegument protein UL36; Provisional
      cd00201
      Location:447 → 477
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:332 → 361
      WW; WW domain
    Nucleotide Protein
    Heading Accession and Version

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