timp3.L TIMP metallopeptidase inhibitor 3 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: timp3.L
Official Full Name: TIMP metallopeptidase inhibitor 3 L homeolog
Primary source: Xenbase:XB-GENE-864869
Locus tag: XELAEV_18002484mg
See related: EnsemblRapid:ENSXLAG00005010537 AllianceGenome:Xenbase:XB-GENE-864869
Gene type: protein coding
RefSeq status: MODEL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: timp3; timp3-A
Summary: Predicted to enable zinc ion binding activity. Predicted to be located in extracellular region. Is expressed in cardiovascular system; dermal system; genital system; liver and biliary system; and musculoskeletal system. Human ortholog(s) of this gene implicated in Sorsby's fundus dystrophy; breast carcinoma; and urinary bladder cancer. Orthologous to human TIMP3 (TIMP metallopeptidase inhibitor 3). [provided by Alliance of Genome Resources, Jan 2025]
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Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3L	NC_054375.1 (6487828..6522057, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8L	NC_030738.1 (2719163..2727557)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	Unplaced Scaffold	NW_016694822.1 (1550522..1589155, complement)

Chromosome 3L - NC_054375.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

only the N-terminal, but not the C-terminal domain of TIMP-3, results in developmental defects.
Title: Domain specific overexpression of TIMP-2 and TIMP-3 reveals MMP-independent functions of TIMPs during Xenopus laevis development.
metamorphic tail and intestine RNA levels of TIMP-2, MT1-MMP and Gel-A, but not MT3-MMP or TIMP-3, are elevated during periods of cell death and proliferation
Title: Membrane type-1 matrix metalloproteinases and tissue inhibitor of metalloproteinases-2 RNA levels mimic each other during Xenopus laevis metamorphosis.

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain

The following Reference Sequences have been suppressed. Explain

NM_001085595.1: Suppressed sequence

Description

NM_001085595.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.