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    nlp-7 Neuropeptide-like protein 7 [ Caenorhabditis elegans ]

    Gene ID: 184647, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nlp-7
    Official Full Name
    Neuropeptide-like protein 7
    Primary source
    WormBase:WBGene00003745
    Locus tag
    CELE_F18E9.2
    See related
    AllianceGenome:WB:WBGene00003745
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including determination of adult lifespan; positive regulation of egg-laying behavior; and response to caloric restriction. Is expressed in egg-laying apparatus and nervous system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nlp-7 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Sequence:
    Chromosome: X; NC_003284.9 (8593181..8594036)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Clip domain-containing protein Neighboring gene DUF148 domain-containing protein;Secreted protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Local neuropeptide signaling modulates serotonergic transmission to shape the temporal organization of C. elegans egg-laying behavior. Banerjee N, et al. PLoS Genet, 2017 Apr. PMID 28384151, Free PMC Article
    2. EGL-38/Pax coordinates development in the Caenhorhabditis elegans egg-laying system through EGF pathway dependent and independent functions. Webb Chasser AM, et al. Mech Dev, 2019 Oct. PMID 31398431, Free PMC Article
    3. Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1. Park SK, et al. Aging Cell, 2009 Jun. PMID 19627265, Free PMC Article
    4. Presynaptic Gαo (GOA-1) signals to depress command neuron excitability and allow stretch-dependent modulation of egg laying in Caenorhabditis elegans. Ravi B, et al. Genetics, 2021 Aug 9. PMID 34037773, Free PMC Article
    5. Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans. Park SK, et al. FASEB J, 2010 Feb. PMID 19783783, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Presynaptic Galphao (GOA-1) signals to depress command neuron excitability and allow stretch-dependent modulation of egg laying in Caenorhabditis elegans.
      Title: Presynaptic Gαo (GOA-1) signals to depress command neuron excitability and allow stretch-dependent modulation of egg laying in Caenorhabditis elegans.
    2. We demonstrate that the modulatory effects of the uv1 cells are mediated by peptides encoded by the nlp-7 and flp-11 genes that act locally to inhibit circuit activity, primarily by inhibiting vesicular release of serotonin from HSN motor neurons.
      Title: Local neuropeptide signaling modulates serotonergic transmission to shape the temporal organization of C. elegans egg-laying behavior.
    3. We conclude that two novel pathways, NLP-7 signaling and endocytosis by coelomocytes, are required for life extension under dietary restriction in C. elegans.
      Title: Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to caloric restriction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to caloric restriction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to paraquat IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to paraquat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Neuropeptide-like protein 7
    NP_001257062.1
    • Confirmed by transcript evidence
    NP_001257063.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8593181..8594036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270134.3 → NP_001257063.1  Neuropeptide-like protein 7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257063.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H8W3Y5, Q19569

    2. NM_001270133.4 → NP_001257062.1  Neuropeptide-like protein 7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257062.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19569
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19569.1

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