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    pik3r3a phosphoinositide-3-kinase, regulatory subunit 3a (gamma) [ Danio rerio (zebrafish) ]

    Gene ID: 406311, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pik3r3aprovided by ZNC
    Official Full Name
    phosphoinositide-3-kinase, regulatory subunit 3a (gamma)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1978
    See related
    Ensembl:ENSDARG00000103038 AllianceGenome:ZFIN:ZDB-GENE-040426-1978
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:73230; wu:fb16a12; wu:fk56b03
    Summary
    Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pik3r3a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (2957516..2988713)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (3115627..3146824)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene leucine-rich repeat-containing protein 38 Neighboring gene zyg-11 family member, cell cycle regulator, like Neighboring gene intracisternal A particle-promoted polypeptide Neighboring gene guanylate kinase 1a Neighboring gene zgc:63882

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transcriptome analysis reveals functional roles of nacreous protein N16 in prednisolone-induced osteoporotic zebrafish. Lin JB, et al. Int J Biol Macromol, 2019 Feb 1. PMID 30219513
    2. Functional and genetic analyses of ZYG11B provide evidences for its involvement in OAVS. Tingaud-Sequeira A, et al. Mol Genet Genomic Med, 2020 Oct. PMID 32738032, Free PMC Article
    3. Immunotoxicity of β-Diketone Antibiotic Mixtures to Zebrafish (Danio rerio) by Transcriptome Analysis. Li F, et al. PLoS One, 2016. PMID 27046191, Free PMC Article
    4. An integrated approach with the zebrafish model for biomonitoring of municipal wastewater effluent and receiving waters. Li C, et al. Water Res, 2018 Mar 15. PMID 29258003
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of phosphatidylinositol 3-kinase complex, class IA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphoinositide-3-kinase, regulatory subunit 3a (gamma)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291329.1 → NP_001278258.1  phosphoinositide-3-kinase, regulatory subunit 3a (gamma)

      See identical proteins and their annotated locations for NP_001278258.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      EH456435, FP102774
      UniProtKB/TrEMBL
      A0A0R4IUJ2, A0A8M1P174
      Related
      ENSDARP00000130273.1, ENSDART00000160715.2
      Conserved Domains (3) summary
      cd09930
      Location:224 → 327
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cl15255
      Location:36 → 145
      SH2; Src homology 2 (SH2) domain
      cl23765
      Location:153 → 212
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    2. NM_213038.2 → NP_998203.2  phosphoinositide-3-kinase, regulatory subunit 3a (gamma)

      See identical proteins and their annotated locations for NP_998203.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      CB359701, EH456435, FP102774
      UniProtKB/TrEMBL
      A0A0R4IUJ2, A0A8M1P174
      Related
      ENSDARP00000140757.1, ENSDART00000167649.2
      Conserved Domains (3) summary
      cd09930
      Location:224 → 327
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cl15255
      Location:36 → 145
      SH2; Src homology 2 (SH2) domain
      cl23765
      Location:153 → 212
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      2957516..2988713
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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