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    Ms4a5 membrane-spanning 4-domains, subfamily A, member 5 [ Mus musculus (house mouse) ]

    Gene ID: 269063, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ms4a5provided by MGI
    Official Full Name
    membrane-spanning 4-domains, subfamily A, member 5provided by MGI
    Primary source
    MGI:MGI:2670985
    See related
    Ensembl:ENSMUSG00000054523 AllianceGenome:MGI:2670985
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in cell surface receptor signaling pathway. Predicted to be active in plasma membrane. Orthologous to human MS4A5 (membrane spanning 4-domains A5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 50.1) See more
    Orthologs
    human all
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    Genomic context

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    See Ms4a5 in Genome Data Viewer
    Location:
    19 A; 19 8.27 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (11251514..11261259, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (11273866..11283895, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930526L06 gene Neighboring gene STARR-seq mESC enhancer starr_45567 Neighboring gene membrane-spanning 4-domains, subfamily A, member 12 Neighboring gene STARR-positive B cell enhancer ABC_E11022 Neighboring gene membrane-spanning 4-domains, subfamily A, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E3243 Neighboring gene STARR-seq mESC enhancer starr_45568 Neighboring gene STARR-seq mESC enhancer starr_45570 Neighboring gene membrane-spanning 4-domains, subfamily A, member 14 Neighboring gene membrane-spanning 4-domains, subfamily A, member 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1) 

    General gene information

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    Homology

    Clone Names

    • MGC58438

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    membrane-spanning 4-domains subfamily A member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418543.1 → NP_001405472.1  membrane-spanning 4-domains subfamily A member 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134839
      UniProtKB/TrEMBL
      Q2TVW9
      Related
      ENSMUSP00000139805.2, ENSMUST00000186937.7

    2. NM_183190.3 → NP_899013.1  membrane-spanning 4-domains subfamily A member 5 isoform 1

      See identical proteins and their annotated locations for NP_899013.1

      Status: VALIDATED

      Source sequence(s)
      AC134839
      Consensus CDS
      CCDS29596.1
      UniProtKB/TrEMBL
      Q810P8
      Related
      ENSMUSP00000066960.7, ENSMUST00000067673.13
      Conserved Domains (1) summary
      pfam04103
      Location:49 → 189
      CD20; CD20-like family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      11251514..11261259 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527124.4 → XP_006527187.1  membrane-spanning 4-domains subfamily A member 5 isoform X1

      Conserved Domains (1) summary
      pfam04103
      Location:49 → 147
      CD20; CD20-like family
    Nucleotide Protein Strain
    Heading Accession and Version

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