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    Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma [ Mus musculus (house mouse) ]

    Gene ID: 26931, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppp2r5cprovided by MGI
    Official Full Name
    protein phosphatase 2, regulatory subunit B', gammaprovided by MGI
    Primary source
    MGI:MGI:1349475
    See related
    Ensembl:ENSMUSG00000017843 AllianceGenome:MGI:1349475
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D12Bwg0916e; 2610043M05Rik; 2700063L20Rik
    Summary
    Predicted to enable protein phosphatase activator activity. Predicted to be involved in negative regulation of cell population proliferation; protein dephosphorylation; and signal transduction by p53 class mediator. Predicted to act upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in Golgi apparatus; chromosome, centromeric region; and nucleoplasm. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including central nervous system; eye; genitourinary system; heart; and hemolymphoid system gland. Orthologous to human PPP2R5C (protein phosphatase 2 regulatory subunit B'gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 41.8), cortex adult (RPKM 18.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppp2r5c in Genome Data Viewer
    Location:
    12 F1; 12 60.56 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (110413532..110549509)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (110447144..110583075)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9063 Neighboring gene STARR-seq mESC enhancer starr_33278 Neighboring gene STARR-seq mESC enhancer starr_33279 Neighboring gene predicted gene, 40577 Neighboring gene STARR-positive B cell enhancer ABC_E4043 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:111701992-111702194 Neighboring gene STARR-seq mESC enhancer starr_33280 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:111716802-111717199 Neighboring gene STARR-positive B cell enhancer ABC_E5354 Neighboring gene STARR-positive B cell enhancer ABC_E1864 Neighboring gene predicted gene, 19605 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:111737456-111737643 Neighboring gene STARR-seq mESC enhancer starr_33286 Neighboring gene STARR-seq mESC enhancer starr_33287 Neighboring gene STARR-seq mESC enhancer starr_33292 Neighboring gene RIKEN cDNA B930059L03 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:111829680-111829789 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:111829792-111829979 Neighboring gene STARR-seq mESC enhancer starr_33294 Neighboring gene predicted gene, 35558 Neighboring gene dynein cytoplasmic 1 heavy chain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Localization of the PP2A B56gamma regulatory subunit at the Golgi complex: possible role in vesicle transport and migration. Ito A, et al. Am J Pathol, 2003 Feb. PMID 12547706, Free PMC Article
    2. PP2A-B56γ is required for an efficient spindle assembly checkpoint. Varadkar P, et al. Cell Cycle, 2017 Jun 18. PMID 28562161, Free PMC Article
    3. A truncated isoform of the protein phosphatase 2A B56gamma regulatory subunit may promote genetic instability and cause tumor progression. Ito A, et al. Am J Pathol, 2003 Jan. PMID 12507892, Free PMC Article
    4. LincR-PPP2R5C deficiency enhancing the fungicidal activity of neutrophils in pulmonary cryptococcosis is linked to the upregulation of IL-4. Yang C, et al. mBio, 2024 Oct 16. PMID 39287443, Free PMC Article
    5. Neural retina leucine-zipper regulates the expression of Ppp2r5c, the regulatory subunit of protein phosphatase 2A, in photoreceptor development. Kim JW, et al. FEBS J, 2010 Dec. PMID 21078119

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LincR-PPP2R5C deficiency enhancing the fungicidal activity of neutrophils in pulmonary cryptococcosis is linked to the upregulation of IL-4.
      Title: LincR-PPP2R5C deficiency enhancing the fungicidal activity of neutrophils in pulmonary cryptococcosis is linked to the upregulation of IL-4.
    2. Inactivation of only the PP2A-B56gamma subunit can affect the efficiency of the spindle assembly checkpoint.
      Title: PP2A-B56γ is required for an efficient spindle assembly checkpoint.
    3. The PP2A B56gamma regulatory subunit controls PP2A substrate specificity in vivo in a manner that cannot be fully compensated for by other B56 subunits.
      Title: The protein phosphatase 2A B56γ regulatory subunit is required for heart development.
    4. B56gamma1 suppressed EGF-induced cell migration on collagen, bound to phosphorylated-ERK, and dephosphorylated ERK.
      Title: Dynamic regulation of extracellular signal-regulated kinase (ERK) by protein phosphatase 2A regulatory subunit B56γ1 in nuclei induces cell migration.
    5. results suggest that Ppp2r5c expression is regulated by Nrl during retinogenesis through direct binding to the promoter region of Ppp2r5c
      Title: Neural retina leucine-zipper regulates the expression of Ppp2r5c, the regulatory subunit of protein phosphatase 2A, in photoreceptor development.
    6. the dynamic nuclear distribution of the B56gamma3 regulatory subunit controls nuclear PP2A activity, which regulates cell cycle controllers, such as p27, to restrain cell cycle progression, and may be responsible for the tumor suppressor function of PP2A
      Title: The B56gamma3 regulatory subunit of protein phosphatase 2A (PP2A) regulates S phase-specific nuclear accumulation of PP2A and the G1 to S transition.
    7. PP-2A is less abundant than PP-1 in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed.
      Title: Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.
    8. A truncated isoform of the protein phosphatase 2A B56gamma regulatory subunit may promote genetic instability and cause tumor progression
      Title: A truncated isoform of the protein phosphatase 2A B56gamma regulatory subunit may promote genetic instability and cause tumor progression.
    9. Identification of a new B56gamma subunit (B56gamma4) specifically expressed in testis.
      Title: Expression of the B56delta subunit of protein phosphatase 2A and Mea1 in mouse spermatogenesis. Identification of a new B56gamma subunit (B56gamma4) specifically expressed in testis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • mKIAA0044

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, centromeric region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein phosphatase type 2A complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
    Names
    B56/PP2A gamma
    Band 8A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081457.3 → NP_001074926.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform b

      See identical proteins and their annotated locations for NP_001074926.1

      Status: VALIDATED

      Source sequence(s)
      AC152827, AK031584, CV558022
      Consensus CDS
      CCDS36558.1
      UniProtKB/Swiss-Prot
      Q60996
      Related
      ENSMUSP00000105458.2, ENSMUST00000109832.3
      Conserved Domains (1) summary
      pfam01603
      Location:34 → 437
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    2. NM_001081458.3 → NP_001074927.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform c

      See identical proteins and their annotated locations for NP_001074927.1

      Status: VALIDATED

      Source sequence(s)
      AK031584, BQ175856, CV558022
      Consensus CDS
      CCDS88404.1
      UniProtKB/TrEMBL
      Q6ZQK4
      Related
      ENSMUSP00000152865.2, ENSMUST00000221715.2
      Conserved Domains (2) summary
      PLN00122
      Location:342 → 443
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:34 → 437
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    3. NM_001135001.2 → NP_001128473.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform d

      Status: VALIDATED

      Source sequence(s)
      AK031584, AK129042, CJ312853, CX217314
      UniProtKB/TrEMBL
      Q6ZQK4
      Conserved Domains (2) summary
      PLN00122
      Location:399 → 500
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:91 → 494
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    4. NM_001364204.1 → NP_001351133.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform e

      Status: VALIDATED

      Source sequence(s)
      AC152827, AL591582
      Conserved Domains (1) summary
      pfam01603
      Location:89 → 494
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    5. NM_001364205.1 → NP_001351134.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform f

      Status: VALIDATED

      Source sequence(s)
      AC152827, AL591582
      Conserved Domains (1) summary
      pfam01603
      Location:32 → 437
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    6. NM_001364206.1 → NP_001351135.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform h

      Status: VALIDATED

      Source sequence(s)
      AC152827, AL591582
      Consensus CDS
      CCDS88403.1
      Related
      ENSMUSP00000152282.2, ENSMUST00000221074.2
      Conserved Domains (1) summary
      pfam01603
      Location:32 → 437
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    7. NM_001364207.1 → NP_001351136.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform i

      Status: VALIDATED

      Source sequence(s)
      AC152827, AL591582
      Conserved Domains (1) summary
      pfam01603
      Location:32 → 380
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    8. NM_001364208.1 → NP_001351137.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform j

      Status: VALIDATED

      Source sequence(s)
      AC152827, AL591582
      UniProtKB/TrEMBL
      Q6ZQK4
      Conserved Domains (1) summary
      pfam01603
      Location:32 → 437
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    9. NM_001364209.1 → NP_001351138.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform k

      Status: VALIDATED

      Source sequence(s)
      AC152827, AL591582
      Conserved Domains (1) summary
      pfam01603
      Location:32 → 380
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    10. NM_001364210.1 → NP_001351139.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform l

      Status: VALIDATED

      Source sequence(s)
      AC152827, AL591582
      Conserved Domains (1) summary
      pfam01603
      Location:32 → 380
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    11. NM_001364211.1 → NP_001351140.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform m

      Status: VALIDATED

      Source sequence(s)
      AC152827, AL591582
      Conserved Domains (1) summary
      pfam01603
      Location:32 → 380
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    12. NM_001364212.1 → NP_001351141.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform n

      Status: VALIDATED

      Source sequence(s)
      AC152827, AL591582
      Conserved Domains (1) summary
      pfam01603
      Location:19 → 357
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    13. NM_001364213.1 → NP_001351142.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform o

      Status: VALIDATED

      Source sequence(s)
      AC152827, AL591582
      Conserved Domains (1) summary
      pfam01603
      Location:1 → 305
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    14. NM_001364214.1 → NP_001351143.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform g

      Status: VALIDATED

      Source sequence(s)
      AC152827, AL591582
      Conserved Domains (1) summary
      pfam01603
      Location:32 → 437
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    15. NM_001373949.1 → NP_001360878.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform p

      Status: VALIDATED

      Source sequence(s)
      AC152827, AL591582
      Conserved Domains (1) summary
      pfam01603
      Location:91 → 494
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    16. NM_001373950.1 → NP_001360879.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform q

      Status: VALIDATED

      Source sequence(s)
      AC152827, AL591582
      Conserved Domains (1) summary
      pfam01603
      Location:91 → 494
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    17. NM_001373951.1 → NP_001360880.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform r

      Status: VALIDATED

      Source sequence(s)
      AC152827, AL591582
      UniProtKB/TrEMBL
      Q6ZQK4
      Conserved Domains (1) summary
      pfam01603
      Location:91 → 474
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    18. NM_001373952.1 → NP_001360881.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform s

      Status: VALIDATED

      Source sequence(s)
      AC152827, AL591582
      Conserved Domains (1) summary
      pfam01603
      Location:2 → 335
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    19. NM_001373953.1 → NP_001360882.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform t

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20), as well as variant 21, encodes isoform t.
      Source sequence(s)
      AC152827, AL591582
      Conserved Domains (1) summary
      pfam01603
      Location:1 → 362
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    20. NM_001373954.1 → NP_001360883.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform t

      Status: VALIDATED

      Description
      Transcript Variant: This variant (21), as well as variant 20, encodes isoform t.
      Source sequence(s)
      AC152827, AL591582
      Conserved Domains (1) summary
      pfam01603
      Location:1 → 362
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    21. NM_012023.4 → NP_036153.2  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform a

      See identical proteins and their annotated locations for NP_036153.2

      Status: VALIDATED

      Source sequence(s)
      AC152827, AK031584, CV558022, CX568604
      Consensus CDS
      CCDS36557.1
      UniProtKB/Swiss-Prot
      O35708, Q60996, Q6TQF7, Q99KW8, Q99N67, Q99N68
      Related
      ENSMUSP00000082053.4, ENSMUST00000084985.11
      Conserved Domains (2) summary
      PLN00122
      Location:342 → 442
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:34 → 437
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    RNA

    1. NR_164198.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591582

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      110413532..110549509
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515924.4 → XP_006515987.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1

      Conserved Domains (1) summary
      pfam01603
      Location:91 → 494
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    2. XM_006515918.4 → XP_006515981.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X2

      Conserved Domains (1) summary
      pfam01603
      Location:91 → 494
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    3. XM_006515923.5 → XP_006515986.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4

      UniProtKB/TrEMBL
      Q6ZQK4
      Conserved Domains (1) summary
      pfam01603
      Location:91 → 494
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    4. XM_006515921.3 → XP_006515984.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X3

      Conserved Domains (1) summary
      pfam01603
      Location:91 → 437
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    5. XM_030246738.2 → XP_030102598.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X5

      UniProtKB/TrEMBL
      Q6ZQK4
      Conserved Domains (1) summary
      pfam01603
      Location:91 → 437
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    6. XM_030246740.1 → XP_030102600.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X6

      Conserved Domains (1) summary
      pfam01603
      Location:1 → 362
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001037934.1: Suppressed sequence

      Description
      NM_001037934.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60996.2 GenPept UniProtKB/Swiss-Prot:Q60996

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