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    egl-17 Uncharacterized protein [ Caenorhabditis elegans ]

    Gene ID: 180402, updated on 9-Dec-2024

    Summary

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    Official Symbol
    egl-17
    Official Full Name
    Uncharacterized protein
    Primary source
    WormBase:WBGene00001185
    Locus tag
    CELE_F38G1.2
    See related
    AllianceGenome:WB:WBGene00001185
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable growth factor activity; type 1 fibroblast growth factor receptor binding activity; and type 2 fibroblast growth factor receptor binding activity. Involved in regulation of cell migration and regulation of egg-laying behavior. Located in extracellular space. Is expressed in several structures, including M4 neuron; P5.p; P7.p; epithelial cell; and proctodeal cell. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 20 with or without anosmia; hypogonadotropic hypogonadism 6 with or without anosmia; and prostate carcinoma in situ. Orthologous to several human genes including FGF18 (fibroblast growth factor 18) and FGF8 (fibroblast growth factor 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See egl-17 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (489685..492318)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene tRNA-Thr Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Asp Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans larvae undergo early developmental arrest on a diet of Gram-positive bacterium Enterococcus faecalis. Dasgupta M, et al. MicroPubl Biol, 2020 Oct 27. PMID 33274333, Free PMC Article
    2. FGF signaling in flies and worms: more and more relevant to vertebrate biology. Huang P, et al. Cytokine Growth Factor Rev, 2005 Apr. PMID 15863031
    3. sem-4/spalt and egl-17/FGF have a conserved role in sex myoblast specification and migration in P. pacificus and C. elegans. Photos A, et al. Dev Biol, 2006 May 1. PMID 16515780
    4. A normally attractive cell interaction is repulsive in two C. elegans mesodermal cell migration mutants. Stern MJ, et al. Development, 1991 Nov. PMID 1821851
    5. Alternative splicing affecting a novel domain in the C. elegans EGL-15 FGF receptor confers functional specificity. Goodman SJ, et al. Development, 2003 Aug. PMID 12835392

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that expression of the fibroblast growth factor-like protein EGL-17 and its receptor EGL-15 is reduced in vrk-1 mutants, suggesting that VRK-1 might act at least partially through activation of FGF signaling.
      Title: Protein kinase VRK-1 regulates cell invasion and EGL-17/FGF signaling in Caenorhabditis elegans.
    2. LET-756, like vertebrate FGF9, -16, and -20, belongs to the FGF9 family, whereas EGL-17, like vertebrate FGF8, -17, and -18, could be included in the FGF8 family [review]
      Title: A pair as a minimum: the two fibroblast growth factors of the nematode Caenorhabditis elegans.
    3. Experimental studies in the egl-17 mutant background indicate a complex set of gonad-dependent and gonad-independent mechanisms required for sex myoblast migration.
      Title: sem-4/spalt and egl-17/FGF have a conserved role in sex myoblast specification and migration in P. pacificus and C. elegans.
    4. EGL-17/FGF signaling through an EGL-15/FGFR isoform and possibly SEM-5/GRB2 mediates both attraction of the migrating sex myoblasts and repulsion of the migrating CAN neurons.
      Title: Sensitized genetic backgrounds reveal a role for C. elegans FGF EGL-17 as a repellent for migrating CAN neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables fibroblast growth factor receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables type 1 fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables type 2 fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fibroblast growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Uncharacterized protein
    NP_508107.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      489685..492318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075706.6 → NP_508107.1  Uncharacterized protein CELE_F38G1.2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508107.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEF1
      Conserved Domains (1) summary
      cl00060
      Location:31 → 159
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
    Nucleotide Protein
    Heading Accession and Version

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