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    ins-4 putative insulin-like peptide beta-type 1 [ Caenorhabditis elegans ]

    Gene ID: 191685, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ins-4
    Official Full Name
    putative insulin-like peptide beta-type 1
    Primary source
    WormBase:WBGene00002087
    Locus tag
    CELE_ZK75.1
    See related
    AllianceGenome:WB:WBGene00002087
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable hormone activity. Involved in dauer larval development; negative regulation of dauer entry; and regulation of synaptic assembly at neuromuscular junction. Predicted to be located in extracellular region. Is expressed in several structures, including gonad; head muscle; neurons; somatic nervous system; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ins-4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003280.10 (5996366..5997008)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene putative insulin-like peptide beta-type 2 Neighboring gene putative insulin-like peptide beta-type 3 Neighboring gene Putative insulin-like peptide beta-type 6 Neighboring gene putative insulin-like peptide beta-type 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BMP pathway regulation of insulin signaling components promotes lipid storage in Caenorhabditis elegans. Clark JF, et al. PLoS Genet, 2021 Oct. PMID 34634043, Free PMC Article
    2. Pheromones Modulate Learning by Regulating the Balanced Signals of Two Insulin-like Peptides. Wu T, et al. Neuron, 2019 Dec 18. PMID 31676170, Free PMC Article
    3. L1 arrest, daf-16/FoxO and nonautonomous control of post-embryonic development. Kaplan RE, et al. Worm, 2016 Apr-Jun. PMID 27383290, Free PMC Article
    4. Males shorten the life span of C. elegans hermaphrodites via secreted compounds. Maures TJ, et al. Science, 2014 Jan 31. PMID 24292626, Free PMC Article
    5. Neuronal ERK MAPK signaling in response to low-dose nanopolystyrene exposure by suppressing insulin peptide expression in Caenorhabditis elegans. Qu M, et al. Sci Total Environ, 2020 Jul 1. PMID 32272418

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ins-4 and daf-28 function redundantly to regulate C. elegans L1 arrest.
      Title: Ins-4 and daf-28 function redundantly to regulate C. elegans L1 arrest.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of dauer entry IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of synaptic assembly at neuromuscular junction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative insulin-like peptide beta-type 1
    NP_495196.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5996366..5997008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062795.2 → NP_495196.1  putative insulin-like peptide beta-type 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495196.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09626
      Conserved Domains (1) summary
      pfam03488
      Location:57 → 104
      Ins_beta; Nematode insulin-related peptide beta type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09626.1

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