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    unc-62 Homeobox domain-containing protein;Homeobox protein unc-62 [ Caenorhabditis elegans ]

    Gene ID: 178845, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-62
    Official Full Name
    Homeobox domain-containing protein;Homeobox protein unc-62
    Primary source
    WormBase:WBGene00006796
    Locus tag
    CELE_T28F12.2
    See related
    AllianceGenome:WB:WBGene00006796
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cell fate specification; muscle cell differentiation; and regulation of gene expression. Acts upstream of or within lipid homeostasis. Located in chromatin and nucleus. Is expressed in several structures, including body wall musculature; hypodermis; neurons; reproductive system; and vulval precursor cell. Used to study leukemia and restless legs syndrome. Human ortholog(s) of this gene implicated in alcohol dependence; cleft palate, cardiac defects, and intellectual disabillity; learning disability; open-angle glaucoma; and orofacial cleft (multiple). Orthologous to several human genes including MEIS1 (Meis homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-62 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    12
    Sequence:
    Chromosome: V; NC_003283.11 (4497463..4511447)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene NADP-dependent oxidoreductase domain-containing protein Neighboring gene Transmembrane protein Neighboring gene Son of sevenless homolog Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of unc-62 expression pattern in C. elegans embryonic AWC neurons. Hsieh YW, et al. MicroPubl Biol, 2022. PMID 35198862, Free PMC Article
    2. Roles of the developmental regulator unc-62/Homothorax in limiting longevity in Caenorhabditis elegans. Van Nostrand EL, et al. PLoS Genet, 2013. PMID 23468654, Free PMC Article
    3. Integrative analysis of C. elegans modENCODE ChIP-seq data sets to infer gene regulatory interactions. Van Nostrand EL, et al. Genome Res, 2013 Jun. PMID 23531767, Free PMC Article
    4. MEIS1 and Restless Legs Syndrome: A Comprehensive Review. Sarayloo F, et al. Front Neurol, 2019. PMID 31551905, Free PMC Article
    5. Maternal Caffeine Intake Disrupts Eggshell Integrity and Retards Larval Development by Reducing Yolk Production in a Caenorhabditis elegans Model. Min H, et al. Nutrients, 2020 May 7. PMID 32392893, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Synergistic roles of homeodomain proteins UNC-62 homothorax and MLS-2 HMX/NKX in the specification of olfactory neurons in Caenorhabditis elegans.
      Title: Synergistic roles of homeodomain proteins UNC-62 homothorax and MLS-2 HMX/NKX in the specification of olfactory neurons in Caenorhabditis elegans.
    2. Different Meis/UNC-62 isoforms act through specific regions of the unc-55 promoter. UNC-62 isoforms differentially regulate the mRNA and protein expression of UNC-55.
      Title: Meis/UNC-62 isoform dependent regulation of CoupTF-II/UNC-55 and GABAergic motor neuron subtype differentiation.
    3. These results illustrate how unc-62 regulation of intestinal gene expression is responsible for limiting lifespan during the normal aging process.
      Title: Roles of the developmental regulator unc-62/Homothorax in limiting longevity in Caenorhabditis elegans.
    4. UNC-62 plays essential roles in regulating cell fate specification & differentiation in the mesodermal M lineage. UNC-62 functions together with CEH-20 in regulating these processes.
      Title: Two Hox cofactors, the Meis/Hth homolog UNC-62 and the Pbx/Exd homolog CEH-20, function together during C. elegans postembryonic mesodermal development.
    5. Functions independently of lin-39 in vulva development.
      Title: The roles of two C. elegans HOX co-factor orthologs in cell migration and vulva development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryonic pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in eye development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mesodermal cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mesodermal cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Homeobox domain-containing protein;Homeobox protein unc-62
    NP_001024169.1
    • Confirmed by transcript evidence
    NP_001024170.1
    • Confirmed by transcript evidence
    NP_001024173.1
    • Confirmed by transcript evidence
    NP_001024175.1
    • Confirmed by transcript evidence
    NP_001300207.1
    • Confirmed by transcript evidence
    NP_001367923.1
    • Confirmed by transcript evidence
    NP_001367924.1
    • Confirmed by transcript evidence
    NP_001370772.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      4497463..4511447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380635.2 → NP_001367923.1  Homeobox protein unc-62 [Caenorhabditis elegans]

      Status: REVIEWED

    2. NM_001028998.5 → NP_001024169.1  Homeobox protein unc-62 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024169.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5TKQ8, Q8MXU6, Q8MXU7, Q8WRQ5, Q8WRQ6, Q9N5D5, Q9N5D6
      Conserved Domains (2) summary
      pfam05920
      Location:410 → 449
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:133 → 218
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    3. NM_001380634.1 → NP_001367924.1  Homeobox protein unc-62 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      pfam05920
      Location:406 → 445
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:133 → 219
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    4. NM_001383298.1 → NP_001370772.1  Homeobox protein unc-62 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam05920
      Location:3 → 38
      Homeobox_KN; Homeobox KN domain

    5. NM_001028999.5 → NP_001024170.1  Homeobox protein unc-62 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024170.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N5D6
      Conserved Domains (2) summary
      pfam05920
      Location:373 → 412
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    6. NM_001029002.4 → NP_001024173.1  Homeobox protein unc-62 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024173.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N5D6
      Conserved Domains (2) summary
      pfam05920
      Location:369 → 408
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    7. NM_001313278.3 → NP_001300207.1  Homeobox domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ASC5
      Conserved Domains (2) summary
      pfam05920
      Location:332 → 371
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:59 → 145
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    8. NM_001029004.5 → NP_001024175.1  Homeobox protein unc-62 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024175.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N5D6
      Conserved Domains (2) summary
      pfam05920
      Location:336 → 375
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:59 → 144
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N5D6.1

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