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    prhg-1 Pleckstrin homology domain-containing family G member 7 [ Caenorhabditis elegans ]

    Gene ID: 190810, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prhg-1
    Official Full Name
    Pleckstrin homology domain-containing family G member 7
    Primary source
    WormBase:WBGene00022391
    Locus tag
    CELE_Y95B8A.12
    See related
    AllianceGenome:WB:WBGene00022391
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Orthologous to human PLEKHG7 (pleckstrin homology and RhoGEF domain containing G7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See prhg-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    13
    Sequence:
    Chromosome: I; NC_003279.8 (912332..926916, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Guanine nucleotide-binding protein alpha-16 subunit Neighboring gene ncRNA Neighboring gene Protein EMP46 Neighboring gene ncRNA Neighboring gene Zinc metalloproteinase nas-30 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Trp

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and comparative analysis of novel alternatively spliced transcripts of RhoGEF domain encoding gene in C. elegans and C. briggsae. Kashyap L, et al. Bioinformation, 2007 Sep 11. PMID 18188419, Free PMC Article
    2. Behavioral and immune responses to infection require Gαq- RhoA signaling in C. elegans. McMullan R, et al. PLoS Pathog, 2012 Feb. PMID 22359503, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Pleckstrin homology domain-containing family G member 7
    NP_001032992.1
    • Confirmed by transcript evidence
    NP_001032993.1
    • Confirmed by transcript evidence
    NP_001122556.1
    • Confirmed by transcript evidence
    NP_001122557.1
    • Partially confirmed by transcript evidence
    NP_001122558.1
    • Partially confirmed by transcript evidence
    NP_001122559.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      912332..926916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129087.2 → NP_001122559.1  Pleckstrin homology domain-containing family G member 7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122559.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0P8
      Conserved Domains (3) summary
      cd13245
      Location:432 → 549
      PH_PLEKHG7; Pleckstrin homology domain-containing family G member 7 pleckstrin homology (PH) domain
      pfam00169
      Location:433 → 553
      PH; PH domain
      pfam00621
      Location:188 → 377
      RhoGEF; RhoGEF domain

    2. NM_001037903.4 → NP_001032992.1  Pleckstrin homology domain-containing family G member 7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001032992.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N2V4
      Conserved Domains (3) summary
      cd13245
      Location:433 → 550
      PH_PLEKHG7; Pleckstrin homology domain-containing family G member 7 pleckstrin homology (PH) domain
      pfam00169
      Location:434 → 554
      PH; PH domain
      pfam00621
      Location:189 → 378
      RhoGEF; RhoGEF domain

    3. NM_001129086.4 → NP_001122558.1  Pleckstrin homology domain-containing family G member 7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122558.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0P7
      Conserved Domains (3) summary
      cd13245
      Location:426 → 543
      PH_PLEKHG7; Pleckstrin homology domain-containing family G member 7 pleckstrin homology (PH) domain
      pfam00169
      Location:427 → 547
      PH; PH domain
      pfam00621
      Location:182 → 371
      RhoGEF; RhoGEF domain

    4. NM_001037904.5 → NP_001032993.1  Pleckstrin homology domain-containing family G member 7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001032993.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0P4
      Conserved Domains (3) summary
      cd13245
      Location:425 → 542
      PH_PLEKHG7; Pleckstrin homology domain-containing family G member 7 pleckstrin homology (PH) domain
      pfam00169
      Location:426 → 546
      PH; PH domain
      pfam00621
      Location:181 → 370
      RhoGEF; RhoGEF domain

    5. NM_001129084.3 → NP_001122556.1  Pleckstrin homology domain-containing family G member 7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122556.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0P5
      Conserved Domains (3) summary
      cd13245
      Location:440 → 557
      PH_PLEKHG7; Pleckstrin homology domain-containing family G member 7 pleckstrin homology (PH) domain
      pfam00169
      Location:441 → 561
      PH; PH domain
      pfam00621
      Location:196 → 385
      RhoGEF; RhoGEF domain

    6. NM_001129085.4 → NP_001122557.1  Pleckstrin homology domain-containing family G member 7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122557.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0P6
      Conserved Domains (3) summary
      cd13245
      Location:434 → 551
      PH_PLEKHG7; Pleckstrin homology domain-containing family G member 7 pleckstrin homology (PH) domain
      pfam00169
      Location:435 → 555
      PH; PH domain
      pfam00621
      Location:190 → 379
      RhoGEF; RhoGEF domain
    Nucleotide Protein
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