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    Neto Neuropilin and tolloid-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32303, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Netoprovided by FlyBase
    Official Full Name
    Neuropilin and tolloid-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0265416
    Locus tag
    Dmel_CG44328
    See related
    AllianceGenome:FB:FBgn0265416
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12727; CG15751; CG15752; CG15753; CG32635; CG44328; CT36003; Dmel\CG44328; net; neto; NETO; tld-like
    Old locus tag
    Dmel_CG15753; Dmel_CG32635
    Summary
    Involved in several processes, including hatching behavior; neuromuscular synaptic transmission; and synapse organization. Located in muscle cell postsynaptic specialization. Part of ionotropic glutamate receptor complex. Is expressed in embryonic/larval neuromuscular junction. Orthologous to human NETO1 (neuropilin and tolloid like 1) and NETO2 (neuropilin and tolloid like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Neto in Genome Data Viewer
    Location:
    11F7-12A2; 1-44 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13445903..13527282)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13339936..13421315)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene SET domain containing 2 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44427 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Patterns and processes of genome-wide divergence between North American and African Drosophila melanogaster. Yukilevich R, et al. Genetics, 2010 Sep. PMID 20551441, Free PMC Article
    2. Functional reconstitution of Drosophila melanogaster NMJ glutamate receptors. Han TH, et al. Proc Natl Acad Sci U S A, 2015 May 12. PMID 25918369, Free PMC Article
    3. Disruption of Drosophila larval muscle structure and function by UNC45 knockdown. Karunendiran A, et al. BMC Mol Cell Biol, 2021 Jul 13. PMID 34256704, Free PMC Article
    4. Neto-mediated intracellular interactions shape postsynaptic composition at the Drosophila neuromuscular junction. Ramos CI, et al. PLoS Genet, 2015 Apr. PMID 25905467, Free PMC Article
    5. Neto-α Controls Synapse Organization and Homeostasis at the Drosophila Neuromuscular Junction. Han TH, et al. Cell Rep, 2020 Jul 7. PMID 32640231, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neto-alpha Controls Synapse Organization and Homeostasis at the Drosophila Neuromuscular Junction.
      Title: Neto-α Controls Synapse Organization and Homeostasis at the Drosophila Neuromuscular Junction.
    2. only Neto-beta restored PAK synaptic accumulation at neto null NMJs. Thus, Neto engages in intracellular interactions that regulate the iGluR subtype composition by preferentially recruiting and/or stabilizing selective receptor subtypes.
      Title: Neto-mediated intracellular interactions shape postsynaptic composition at the Drosophila neuromuscular junction.
    3. neto null mutants rescued with a Neto variant that cannot be processed have severely impaired NMJs and reduced iGluRs synaptic clusters. Unprocessed Neto retains the ability to engage iGluRs in vivo and to form complexes with normal synaptic transmission
      Title: Prodomain removal enables neto to stabilize glutamate receptors at the Drosophila neuromuscular junction.
    4. these studies reveal that Drosophila Neto is a novel, essential component of the iGluR complexes and is required for iGluR clustering, organization of PSDs, and synapse functionality.
      Title: Drosophila Neto is essential for clustering glutamate receptors at the neuromuscular junction.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 13463700-13469219 mobile_element_type = transposon:mdg3{}119

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in flight IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glutamate receptor clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hatching behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in postsynaptic density organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in postsynaptic membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ionotropic glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in muscle cell postsynaptic specialization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuropilin and tolloid-like
    Names
    CG44328-PA
    CG44328-PB
    Neto-PA
    Neto-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13445903..13527282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298282.1 → NP_001285211.1  neuropilin and tolloid-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285211.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4LU05
      Conserved Domains (2) summary
      cd00041
      Location:151 → 252
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:392 → 426
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    2. NM_167371.2 → NP_727708.1  neuropilin and tolloid-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727708.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZJ8, Q9VYC7
      Related
      FBpp0308759
      Conserved Domains (2) summary
      cd00041
      Location:151 → 252
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:392 → 426
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G4LU05 G4LU05
    Q9VYC7 Q9VYC7

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