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    skap2 src kinase associated phosphoprotein 2 [ Danio rerio (zebrafish) ]

    Gene ID: 368564, updated on 4-Jan-2025

    Summary

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    Official Symbol
    skap2provided by ZNC
    Official Full Name
    src kinase associated phosphoprotein 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030616-438
    See related
    Ensembl:ENSDARG00000000906 AllianceGenome:ZFIN:ZDB-GENE-030616-438
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    scap2; SKAP55; zgc:65975; zgc:158223; si:dz31b14.4; si:dz227h09.6
    Summary
    Predicted to enable kinase activity. Predicted to act upstream of or within B cell activation and phosphorylation. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human SKAP2 (src kinase associated phosphoprotein 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See skap2 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (20934494..20977712)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (21128539..21171890)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101886298 Neighboring gene homeobox A2b Neighboring gene sorting nexin 10b Neighboring gene chromobox homolog 3b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. miR-34b regulates multiciliogenesis during organ formation in zebrafish. Wang L, et al. Development, 2013 Jul. PMID 23698347
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC65975

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    src kinase-associated phosphoprotein 2
    Names
    SKAP55 homolog
    src family-associated phosphoprotein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200628.1 → NP_956922.1  src kinase-associated phosphoprotein 2

      See identical proteins and their annotated locations for NP_956922.1

      Status: PROVISIONAL

      Source sequence(s)
      BC057253
      UniProtKB/Swiss-Prot
      Q6PG29
      Related
      ENSDARP00000052659.5, ENSDART00000052660.7
      Conserved Domains (3) summary
      cd12045
      Location:283 → 335
      SH3_SKAP2; Src Homology 3 domain of Src Kinase-Associated Phosphoprotein 2
      cd13381
      Location:106 → 211
      PH_Skap-hom_Skap2; Src kinase-associated phosphoprotein homolog and Skap 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:106 → 208
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      20934494..20977712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213909.1 → XP_068070010.1  src kinase-associated phosphoprotein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6PG29

    2. XM_005157963.5 → XP_005158020.1  src kinase-associated phosphoprotein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B4Y0
      Conserved Domains (3) summary
      cd12045
      Location:282 → 334
      SH3_SKAP2; Src Homology 3 domain of Src Kinase-Associated Phosphoprotein 2
      cd13381
      Location:106 → 211
      PH_Skap-hom_Skap2; Src kinase-associated phosphoprotein homolog and Skap 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:106 → 208
      PH; PH domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PG29.1 GenPept UniProtKB/Swiss-Prot:Q6PG29

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