e2f4 E2F transcription factor 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: e2f4provided by ZNC
Official Full Name: E2F transcription factor 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2773
See related: Ensembl:ENSDARG00000101578 AllianceGenome:ZFIN:ZDB-GENE-040426-2773
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb72f07; zgc:63815; wu:fb72f07; wu:fe05f06
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in adenohypophysis; head; and trunk. Human ortholog(s) of this gene implicated in Lynch syndrome. Orthologous to human E2F4 (E2F transcription factor 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (17405201..17419101)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (17308801..17322697)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

E2f4 is required for intestinal and otolith development in zebrafish.
Title: E2f4 is required for intestinal and otolith development in zebrafish.
Transcription factors E2f4 iand E2f5 are required for multiciliogenesis in zebrafish.
Title: E2F4/5-mediated transcriptional control of multiciliated cell differentiation: redundancy or fine-tuning?

Submit: New GeneRIF Correction

General gene information

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Markers

fb72f07 (e-PCR)
- UniSTS:187417

fe05f06.x1 (e-PCR)
- UniSTS:195990

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor E2F4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213432.2 → NP_998597.2 transcription factor E2F4

Status: VALIDATED

Source sequence(s)

EH584432, FO904859

UniProtKB/TrEMBL

A0A0R4ICD5, A0A8M1PF65

Related

ENSDARP00000132304.1, ENSDART00000164349.2

Conserved Domains (2) summary

cd14660
Location:102 → 206

E2F_DD; Dimerization domain of E2F transcription factors

pfam02319
Location:26 → 90

E2F_TDP; E2F/DP family winged-helix DNA-binding domain