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    brd8b bromodomain containing 8b [ Danio rerio (zebrafish) ]

    Gene ID: 337414, updated on 4-Jan-2025

    Summary

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    Official Symbol
    brd8bprovided by ZNC
    Official Full Name
    bromodomain containing 8bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030722-10
    See related
    Ensembl:ENSDARG00000025071 AllianceGenome:ZFIN:ZDB-GENE-030722-10
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    brd8; cb555; zgc:66249; wu:fj66h01; wu:fj84g12
    Summary
    Acts upstream of or within hematopoietic progenitor cell differentiation. Is expressed in nervous system; pectoral fin musculature; pharyngeal arch 3-7 skeleton; post-vent region; and primordial germ cell. Orthologous to human BRD8 (bromodomain containing 8). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See brd8b in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (7697694..7740058)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (7391287..7433794)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene DND microRNA-mediated repression inhibitor 1 Neighboring gene GDNF family receptor alpha 3 Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene si:ch211-39i2.2 Neighboring gene stimulator of interferon response cGAMP interactor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Chronic PFOS Exposure Disrupts Thyroid Structure and Function in Zebrafish. Chen J, et al. Bull Environ Contam Toxicol, 2018 Jul. PMID 29802430
    2. Both STING and MAVS fish orthologs contribute to the induction of interferon mediated by RIG-I. Biacchesi S, et al. PLoS One, 2012. PMID 23091644, Free PMC Article
    3. Methyl mercury suppresses the formation of the tail primordium in developing zebrafish embryos. Yang L, et al. Toxicol Sci, 2010 Jun. PMID 20181659
    4. Molecular targets of TBBPA in zebrafish analysed through integration of genomic and proteomic approaches. De Wit M, et al. Chemosphere, 2008 Dec. PMID 18976794
    5. Efficient identification of CRISPR/Cas9-induced insertions/deletions by direct germline screening in zebrafish. Brocal I, et al. BMC Genomics, 2016 Mar 24. PMID 27009152, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bromodomain-containing protein 8
    Names
    bromodomain containing 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431083.1 → NP_001418012.1  bromodomain-containing protein 8 isoform 1

      Status: VALIDATED

      Source sequence(s)
      FP015863, FP017217
      UniProtKB/TrEMBL
      A0A8M6Z2L2, Q6PFM2

    2. NM_212777.2 → NP_997942.2  bromodomain-containing protein 8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      FP015863, FP017217
      UniProtKB/TrEMBL
      Q6PFM2
      Related
      ENSDARP00000031318.6, ENSDART00000028623.8

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      7697694..7740058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017358993.3 → XP_017214482.1  bromodomain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z445, Q6PFM2

    2. XM_005157127.5 → XP_005157184.1  bromodomain-containing protein 8 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B3X0, Q6PFM2
      Conserved Domains (2) summary
      cd05507
      Location:664 → 767
      Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...
      pfam08890
      Location:73 → 143
      Phage_TAC_5; Phage XkdN-like tail assembly chaperone protein, TAC

    3. XM_005157128.5 → XP_005157185.1  bromodomain-containing protein 8 isoform X3

      UniProtKB/TrEMBL
      A0A8M2B380, Q6PFM2
      Conserved Domains (2) summary
      cd05507
      Location:664 → 767
      Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...
      pfam08890
      Location:73 → 143
      Phage_TAC_5; Phage XkdN-like tail assembly chaperone protein, TAC

    4. XM_005157131.5 → XP_005157188.1  bromodomain-containing protein 8 isoform X5

      UniProtKB/TrEMBL
      A0A8M2B3A4, Q6PFM2
      Related
      ENSDARP00000111047.3, ENSDART00000123139.4
      Conserved Domains (2) summary
      cd05507
      Location:664 → 767
      Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...
      pfam08890
      Location:73 → 143
      Phage_TAC_5; Phage XkdN-like tail assembly chaperone protein, TAC

    5. XM_017358995.3 → XP_017214484.1  bromodomain-containing protein 8 isoform X4

      UniProtKB/TrEMBL
      A0A8M6Z9T3, Q6PFM2

    6. XM_068213171.1 → XP_068069272.1  bromodomain-containing protein 8 isoform X6

      UniProtKB/TrEMBL
      Q6PFM2
    Nucleotide Protein Strain
    Heading Accession and Version

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