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    Trip10 thyroid hormone receptor interactor 10 [ Mus musculus (house mouse) ]

    Gene ID: 106628, updated on 27-Nov-2024

    Summary

    Official Symbol
    Trip10provided by MGI
    Official Full Name
    thyroid hormone receptor interactor 10provided by MGI
    Primary source
    MGI:MGI:2146901
    See related
    Ensembl:ENSMUSG00000019487 AllianceGenome:MGI:2146901
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cip4
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in epithelial to mesenchymal transition; negative regulation of cardiac muscle cell apoptotic process; and positive regulation of cell growth involved in cardiac muscle cell development. Predicted to be located in nucleoplasm. Is expressed in several structures, including clavicle; cranium; inner ear; submandibular gland primordium; and trigeminal ganglion. Orthologous to human TRIP10 (thyroid hormone receptor interactor 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 19.3), heart adult (RPKM 17.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Trip10 in Genome Data Viewer
    Location:
    17 D; 17 29.74 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57540227..57570712)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (57233220..57263697)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor (ligand) superfamily, member 14 Neighboring gene complement component 3 Neighboring gene STARR-positive B cell enhancer ABC_E8688 Neighboring gene microRNA 6978 Neighboring gene G protein-coupled receptor 108 Neighboring gene STARR-positive B cell enhancer ABC_E54 Neighboring gene STARR-positive B cell enhancer ABC_E8689 Neighboring gene STARR-positive B cell enhancer ABC_E615 Neighboring gene SH2 domain containing 3A pseudogene Neighboring gene predicted gene, 52326

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagocytic cup IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cdc42-interacting protein 4
    Names
    Cdc42 interacting protein-4
    TR-interacting protein 10
    TRIP-10
    thyroid receptor-interacting protein 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242389.2NP_001229318.1  cdc42-interacting protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001229318.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      CT025692
      Consensus CDS
      CCDS89129.1
      UniProtKB/Swiss-Prot
      Q8BTR8, Q8CJ53, Q8R433, Q99LI0
      Related
      ENSMUSP00000153081.2, ENSMUST00000224152.2
      Conserved Domains (3) summary
      cd07653
      Location:5257
      F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11628
      Location:395475
      HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
      cd11911
      Location:546600
      SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
    2. NM_001242390.2NP_001229319.1  cdc42-interacting protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001229319.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      CT025692
      Consensus CDS
      CCDS89130.1
      UniProtKB/Swiss-Prot
      Q8CJ53
      Related
      ENSMUSP00000153576.2, ENSMUST00000224885.2
      Conserved Domains (3) summary
      cd07653
      Location:5257
      F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11628
      Location:395475
      HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
      cd11911
      Location:545599
      SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
    3. NM_001242391.2NP_001229320.1  cdc42-interacting protein 4 isoform 4

      See identical proteins and their annotated locations for NP_001229320.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but lacks two alternate internal segments compared to isoform 1.
      Source sequence(s)
      CT025692
      Consensus CDS
      CCDS89131.1
      UniProtKB/Swiss-Prot
      Q8CJ53
      Related
      ENSMUSP00000019631.11, ENSMUST00000019631.11
      Conserved Domains (3) summary
      cd07653
      Location:5257
      F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11628
      Location:339419
      HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
      cd11911
      Location:489543
      SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
    4. NM_001410293.1NP_001397222.1  cdc42-interacting protein 4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      CT025692
    5. NM_001410294.1NP_001397223.1  cdc42-interacting protein 4 isoform 6

      Status: VALIDATED

      Source sequence(s)
      CT025692
    6. NM_001410295.1NP_001397224.1  cdc42-interacting protein 4 isoform 7

      Status: VALIDATED

      Source sequence(s)
      CT025692
    7. NM_001410296.1NP_001397225.1  cdc42-interacting protein 4 isoform 8

      Status: VALIDATED

      Source sequence(s)
      CT025692
    8. NM_001410297.1NP_001397226.1  cdc42-interacting protein 4 isoform 9

      Status: VALIDATED

      Source sequence(s)
      CT025692
    9. NM_001410298.1NP_001397227.1  cdc42-interacting protein 4 isoform 10

      Status: VALIDATED

      Source sequence(s)
      CT025692
    10. NM_001410299.1NP_001397228.1  cdc42-interacting protein 4 isoform 11

      Status: VALIDATED

      Source sequence(s)
      CT025692
    11. NM_001410300.1NP_001397229.1  cdc42-interacting protein 4 isoform 12

      Status: VALIDATED

      Source sequence(s)
      CT025692
    12. NM_001410301.1NP_001397230.1  cdc42-interacting protein 4 isoform 13

      Status: VALIDATED

      Source sequence(s)
      CT025692
    13. NM_001410302.1NP_001397231.1  cdc42-interacting protein 4 isoform 14

      Status: VALIDATED

      Source sequence(s)
      CT025692
    14. NM_001410303.1NP_001397232.1  cdc42-interacting protein 4 isoform 15

      Status: VALIDATED

      Source sequence(s)
      CT025692
    15. NM_134125.5NP_598886.1  cdc42-interacting protein 4 isoform 3

      See identical proteins and their annotated locations for NP_598886.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      CT025692
      Consensus CDS
      CCDS28930.1
      UniProtKB/Swiss-Prot
      Q8CJ53
      Related
      ENSMUSP00000153467.2, ENSMUST00000224947.2
      Conserved Domains (3) summary
      cd07653
      Location:5257
      F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11628
      Location:339419
      HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
      cd11911
      Location:490544
      SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      57540227..57570712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523401.5XP_006523464.1  cdc42-interacting protein 4 isoform X2

      Conserved Domains (3) summary
      cd11628
      Location:360440
      HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
      cd11911
      Location:511565
      SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
      cl12013
      Location:31222
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. XM_006523400.4XP_006523463.1  cdc42-interacting protein 4 isoform X1

      Conserved Domains (3) summary
      cd07653
      Location:5238
      F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11628
      Location:376456
      HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
      cd11911
      Location:527581
      SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4