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    Wnt1 wingless-type MMTV integration site family, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 22408, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wnt1provided by MGI
    Official Full Name
    wingless-type MMTV integration site family, member 1provided by MGI
    Primary source
    MGI:MGI:98953
    See related
    Ensembl:ENSMUSG00000022997 AllianceGenome:MGI:98953
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sw; Int-1; Wnt-1; swaying
    Summary
    Enables cytokine activity and protein domain specific binding activity. Involved in several processes, including central nervous system development; embryonic brain development; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including nervous system development; positive regulation of hematopoietic stem cell proliferation; and regulation of protein metabolic process. Located in cell surface and extracellular region. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo ectoderm; and genitourinary system. Used to study breast cancer. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 15. Orthologous to human WNT1 (Wnt family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 2.1), testis adult (RPKM 1.8) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Wnt1 in Genome Data Viewer
    Location:
    15 F1; 15 54.65 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98687738..98691711)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98789857..98793830)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene ARF GTPase 3 Neighboring gene uncharacterized LOC115488470 Neighboring gene wingless-type MMTV integration site family, member 10B Neighboring gene dendrin Neighboring gene protein kinase, AMP-activated, gamma 1 non-catalytic subunit Neighboring gene STARR-positive B cell enhancer ABC_E1918

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in Spemann organizer formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within T cell differentiation in thymus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within animal organ morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in animal organ regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in animal organ regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in astrocyte-dopaminergic neuron signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bone development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bone development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in canonical Wnt signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell proliferation in midbrain IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell-cell signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to peptide hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in central nervous system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cerebellum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cerebellum formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within diencephalon development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in dopaminergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dopaminergic neuron differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in embryonic axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic brain development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within forebrain anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of hematopoietic stem cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within hematopoietic stem cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hepatocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hepatocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within inner ear morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within metencephalon development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in midbrain development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within midbrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in midbrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in midbrain dopaminergic neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in midbrain dopaminergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within midbrain-hindbrain boundary development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within midbrain-hindbrain boundary maturation during brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within myoblast fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within myoblast fusion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within myotube differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell-substrate adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cellular senescence IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neurogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within neuron fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron fate determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of dermatome development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of dermatome development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of hematopoietic stem cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of insulin-like growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lamellipodium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to wounding IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in signal transduction in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spinal cord association neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Wnt signalosome IC
    Inferred by Curator
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    proto-oncogene Wnt-1
    Names
    proto-oncogene Int-1
    proto-oncogene protein Wnt-1
    wingless-related MMTV integration site 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021279.4NP_067254.1  proto-oncogene Wnt-1 precursor

      See identical proteins and their annotated locations for NP_067254.1

      Status: VALIDATED

      Source sequence(s)
      AC156543, AK141669
      Consensus CDS
      CCDS27807.1
      UniProtKB/Swiss-Prot
      P04426
      UniProtKB/TrEMBL
      Q3UR96
      Related
      ENSMUSP00000023734.8, ENSMUST00000023734.8
      Conserved Domains (1) summary
      smart00097
      Location:60370
      WNT1; found in Wnt-1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      98687738..98691711
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)