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    ZNF835 zinc finger protein 835 [ Homo sapiens (human) ]

    Gene ID: 90485, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF835provided by HGNC
    Official Full Name
    zinc finger protein 835provided by HGNC
    Primary source
    HGNC:HGNC:34332
    See related
    Ensembl:ENSG00000127903 AllianceGenome:HGNC:34332
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BC37295_3
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 1.2), brain (RPKM 0.9) and 20 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF835 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (56661980..56671757, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (59756128..59765893, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57173348..57183125, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11070 Neighboring gene ZNF71-SMIM17 readthrough (NMD candidate) Neighboring gene zinc finger protein 71 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:57128366-57128584 Neighboring gene Sharpr-MPRA regulatory region 15209 Neighboring gene small integral membrane protein 17 Neighboring gene uncharacterized LOC105372473 Neighboring gene uncharacterized LOC105372472 Neighboring gene olfactory receptor family 5 subfamily AH member 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II. Li Y, et al. Nat Commun, 2018 Oct 22. PMID 30349055, Free PMC Article
    2. A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome. Blandin G, et al. Skelet Muscle, 2013 Feb 15. PMID 23414517, Free PMC Article
    3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 835

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005850.3 → NP_001005850.2  zinc finger protein 835

      See identical proteins and their annotated locations for NP_001005850.2

      Status: VALIDATED

      Source sequence(s)
      AC007228, AK023017, AK299565, DB536138, DC382896
      Consensus CDS
      CCDS56105.1
      UniProtKB/Swiss-Prot
      B7Z5Y0, G3V1S0, Q9Y2P0
      Related
      ENSP00000444747.1, ENST00000537055.4
      Conserved Domains (5) summary
      COG5048
      Location:136 → 487
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:140 → 160
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:474 → 496
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:348 → 373
      zf-H2C2_2; Zinc-finger double domain
      cl00955
      Location:178 → 243
      Ribosomal_L34e; Ribosomal protein L34e

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      56661980..56671757 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005259382.3 → XP_005259439.1  zinc finger protein 835 isoform X1

      See identical proteins and their annotated locations for XP_005259439.1

      UniProtKB/Swiss-Prot
      B7Z5Y0, G3V1S0, Q9Y2P0
      Conserved Domains (5) summary
      COG5048
      Location:136 → 487
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:140 → 160
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:474 → 496
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:348 → 373
      zf-H2C2_2; Zinc-finger double domain
      cl00955
      Location:178 → 243
      Ribosomal_L34e; Ribosomal protein L34e

    2. XM_005259383.4 → XP_005259440.1  zinc finger protein 835 isoform X1

      See identical proteins and their annotated locations for XP_005259440.1

      UniProtKB/Swiss-Prot
      B7Z5Y0, G3V1S0, Q9Y2P0
      Conserved Domains (5) summary
      COG5048
      Location:136 → 487
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:140 → 160
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:474 → 496
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:348 → 373
      zf-H2C2_2; Zinc-finger double domain
      cl00955
      Location:178 → 243
      Ribosomal_L34e; Ribosomal protein L34e

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      59756128..59765893 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322553.1 → XP_054178528.1  zinc finger protein 835 isoform X1

    2. XM_054322552.1 → XP_054178527.1  zinc finger protein 835 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y2P0.2 GenPept UniProtKB/Swiss-Prot:Q9Y2P0

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