NUDT7 MutT/nudix family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: NUDT7
Official Full Name: MutT/nudix family protein
Primary source: TAIR:AT4G12720
Locus tag: AT4G12720
See related: Araport:AT4G12720
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: Arabidopsis thaliana Nudix hydrolase homolog 7; AtNUDT7; ATNUDX7; GFG1; GROWTH FACTOR GENE 1; T20K18.70; T20K18_70
Summary: Encodes a protein with ADP-ribose hydrolase activity. Negatively regulates EDS1-conditioned plant defense and programmed cell death.
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Genomic context

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See NUDT7 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 9

Sequence:: Chromosome: 4; NC_003075.7 (7487225..7490127)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The active and inactive AtNUDX6 proteins induced the expression of thioredoxin-h5 while the active and inactive AtNUDX7 proteins suppressed the accumulation of SA and subsequent gene expression, indicating that AtNUDX6 and 7 proteins themselves play distinct roles in stress responses. [AtNUDX7]
Title: Modulation of NADH Levels by Arabidopsis Nudix Hydrolases, AtNUDX6 and 7, and the Respective Proteins Themselves Play Distinct Roles in the Regulation of Various Cellular Responses Involved in Biotic/Abiotic Stresses.
provide evidence that AtERF1 is important for regulating AtNudt7 during oxidative signaling.
Title: A GCC-box motif in the promoter of nudix hydrolase 7 (AtNUDT7) gene plays a role in ozone response of Arabidopsis ecotypes.
AtNUDT7 is important for NAD:NADH homeostasis in seeds.
Title: Arabidopsis nudix hydrolase 7 plays a role in seed germination.
NUDT7 forms complexes in vitro and in vivo with regulatory proteins involved in signal transduction.
Title: Arabidopsis thaliana Nudix hydrolase AtNUDT7 forms complexes with the regulatory RACK1A protein and Ggamma subunits of the signal transducing heterotrimeric G protein.
AtNUDT7 protein levels are induced in response to biotic and abiotic stresses. AtNUDT7 plays an important role in maintaining redox homeostasis, particularly for maintaining NADH:NAD+ balance for normal growth and development.
Title: Modulation of redox homeostasis under suboptimal conditions by Arabidopsis nudix hydrolase 7.
Under oxidative stress, AtNUDX7 serves to maintain NAD(+) levels by supplying ATP via nucleotide recycling from free ADP-Rib molecules and thus regulates the defense mechanisms against oxidative DNA damage via modulation of the PAR reaction. [AtNUDX7]
Title: Modulation of the poly(ADP-ribosyl)ation reaction via the Arabidopsis ADP-ribose/NADH pyrophosphohydrolase, AtNUDX7, is involved in the response to oxidative stress.
structure-activity studies: mutation of specific residues in AtNUDT7 alters function; mutation of residues F73 & V168 disallows dimer formation & enzymatic activity; mutation of residues V69, F73, & V168 disrupts binding to regulatory 14-3-3 protein
Title: Mutational analysis of the AtNUDT7 Nudix hydrolase from Arabidopsis thaliana reveals residues required for protein quaternary structure formation and activity.
A role for poly(ADP-ribosyl)ation in plant defense responses was suggested initially by the upregulated expression of genes encoding NUDT7 and poly(ADP-ribose) glycohydrolase in multiple R-avr interactions.
Title: Discovery of ADP-ribosylation and other plant defense pathway elements through expression profiling of four different Arabidopsis-Pseudomonas R-avr interactions.
functions to modulate the defense response to prevent excessive stimulation, ADP-ribose and NADH are preferred substrates
Title: AtNUDT7, a negative regulator of basal immunity in Arabidopsis, modulates two distinct defense response pathways and is involved in maintaining redox homeostasis.
GFG1 is a key gene linking cellular metabolism and oxidative signaling.
Title: Analysis of Arabidopsis growth factor gene 1 (GFG1) encoding a nudix hydrolase during oxidative signaling.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001203778.1

Supported by ESTs:

NM_001340798.1

Supported by ESTs:

NM_001340799.1

Supported by ESTs:

NM_117341.5

Supported by ESTs:

NM_179036.4

Supported by ESTs:

NM_179037.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ADP-glucose pyrophosphohydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables ADP-ribose diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables ADP-ribose pyrophosphohydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD binding	IDA Inferred from Direct Assay more info	PubMed
enables NAD+ diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD+ diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to hypoxia	HEP more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within innate immune response-activating signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant-type hypersensitive response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein poly-ADP-ribosylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of starch biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to ozone	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to salt stress	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in cytosol	ISM Inferred from Sequence Model more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: MutT/nudix family protein

NP_001190707.1

NUDT7; CONTAINS InterPro DOMAIN/s: NUDIX hydrolase domain-like (InterPro:IPR015797), Nudix hydrolase 6-like (InterPro:IPR003293), NUDIX hydrolase domain (InterPro:IPR000086); BEST Arabidopsis thaliana protein match is: nudix hydrolase homolog 6 (TAIR:AT2G04450.1).

NP_193008.1

NUDT7; FUNCTIONS IN: in 6 functions; INVOLVED IN: in 8 processes; LOCATED IN: cytosol; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: NUDIX hydrolase domain-like (InterPro:IPR015797), NUDIX hydrolase, conserved site (InterPro:IPR020084), Nudix hydrolase 6-like (InterPro:IPR003293), NUDIX hydrolase domain (InterPro:IPR000086); BEST Arabidopsis thaliana protein match is: nudix hydrolase homolog 6 (TAIR:AT2G04450.1); Has 1663 Blast hits to 1661 proteins in 413 species: Archae - 2; Bacteria - 838; Metazoa - 192; Fungi - 6; Plants - 162; Viruses - 1; Other Eukaryotes - 462 (source: NCBI BLink).

NP_849367.1

Arabidopsis thaliana Nudix hydrolase homolog 7 (AtNUDT7); FUNCTIONS IN: in 6 functions; INVOLVED IN: in 8 processes; LOCATED IN: cytosol; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: NUDIX hydrolase domain-like (InterPro:IPR015797), NUDIX hydrolase, conserved site (InterPro:IPR020084), Nudix hydrolase 6-like (InterPro:IPR003293), NUDIX hydrolase domain (InterPro:IPR000086); BEST Arabidopsis thaliana protein match is: nudix hydrolase homolog 6 (TAIR:AT2G04450.1); Has 1663 Blast hits to 1661 proteins in 413 species: Archae - 2; Bacteria - 838; Metazoa - 192; Fungi - 6; Plants - 162; Viruses - 1; Other Eukaryotes - 462 (source: NCBI BLink).

NP_849368.1

Arabidopsis thaliana Nudix hydrolase homolog 7 (AtNUDT7); FUNCTIONS IN: in 6 functions; INVOLVED IN: in 8 processes; LOCATED IN: cytosol; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: NUDIX hydrolase domain-like (InterPro:IPR015797), NUDIX hydrolase, conserved site (InterPro:IPR020084), Nudix hydrolase 6-like (InterPro:IPR003293), NUDIX hydrolase domain (InterPro:IPR000086); BEST Arabidopsis thaliana protein match is: nudix hydrolase homolog 6 (TAIR:AT2G04450.1); Has 1663 Blast hits to 1661 proteins in 413 species: Archae - 2; Bacteria - 838; Metazoa - 192; Fungi - 6; Plants - 162; Viruses - 1; Other Eukaryotes - 462 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

7487225..7490127

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_179036.4 → NP_849367.1 MutT/nudix family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849367.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LEK5, Q9SU14

UniProtKB/TrEMBL

A0A178V4N8, A0A7G2F074

Conserved Domains (2) summary

pfam18290
Location:11 → 89

Nudix_hydro; Nudix hydrolase domain

cl00447
Location:102 → 235

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
NM_001340798.1 → NP_001329574.1 MutT/nudix family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B846
NM_117341.5 → NP_193008.1 MutT/nudix family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_193008.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LEK5, Q9SU14

UniProtKB/TrEMBL

A0A178V4N8, A0A7G2F074

Conserved Domains (2) summary

pfam18290
Location:11 → 89

Nudix_hydro; Nudix hydrolase domain

cl00447
Location:102 → 235

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
NM_001203778.1 → NP_001190707.1 MutT/nudix family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190707.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A7G2F074, F4JRE7

Conserved Domains (1) summary

cl00447
Location:102 → 275

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
NM_179037.3 → NP_849368.1 MutT/nudix family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849368.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LEK5, Q9SU14

UniProtKB/TrEMBL

A0A178V4N8, A0A7G2F074

Conserved Domains (2) summary

pfam18290
Location:11 → 89

Nudix_hydro; Nudix hydrolase domain

cl00447
Location:102 → 235

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
NM_001340799.1 → NP_001329573.1 MutT/nudix family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B842