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    CCT6B chaperonin containing TCP1 subunit 6B [ Homo sapiens (human) ]

    Gene ID: 10693, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CCT6Bprovided by HGNC
    Official Full Name
    chaperonin containing TCP1 subunit 6Bprovided by HGNC
    Primary source
    HGNC:HGNC:1621
    See related
    Ensembl:ENSG00000132141 MIM:610730; AllianceGenome:HGNC:1621
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Cctz2; CCTZ-2; TSA303; CCT-zeta-2; TCP-1-zeta-2
    Summary
    This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
    Expression
    Biased expression in testis (RPKM 57.4) and thyroid (RPKM 1.2) See more
    Orthologs
    mouse all
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    Genomic context

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    See CCT6B in Genome Data Viewer
    Location:
    17q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (34927861..34961460, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (35874857..35908474, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (33254880..33288479, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903987 Neighboring gene uncharacterized LOC105371742 Neighboring gene MPRA-validated peak2814 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:33125526-33126225 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:33145950-33146154 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:33147431-33148040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33153032-33153566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33153567-33154101 Neighboring gene Sharpr-MPRA regulatory region 1211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12046 Neighboring gene Sharpr-MPRA regulatory region 18 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12050 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8432 Neighboring gene zinc finger protein 830 Neighboring gene DNA ligase 3 Neighboring gene oligosaccharyltransferase complex subunit pseudogene 7 Neighboring gene ring finger and FYVE like domain containing E3 ubiquitin protein ligase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The genetic landscape of mutations in Burkitt lymphoma. Love C, et al. Nat Genet, 2012 Dec. PMID 23143597, Free PMC Article
    2. Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method. Ozaki K, et al. Genomics, 1996 Sep 1. PMID 8812458
    3. Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1. Kubota H, et al. FEBS Lett, 1997 Jan 27. PMID 9013858
    4. PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates. Stirling PC, et al. J Biol Chem, 2006 Mar 17. PMID 16415341
    5. The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis. Gestaut D, et al. Cell, 2019 Apr 18. PMID 30955883, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. antagonistic actions of PhLP3 and prefoldin serve to modulate CCT activity and play a key role in establishing a functional cytoskeleton in vivo
      Title: PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates.
    2. Describes the cloning of a very similar protein in mouse.
      Title: Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein folding chaperone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chaperonin-containing T-complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    T-complex protein 1 subunit zeta-2
    Names
    chaperonin containing TCP1, subunit 6B (zeta 2)
    chaperonin-containing T-complex polypeptide 1, subunit 6B
    testis-specific Tcp20
    testis-specific protein TSA303

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193529.3 → NP_001180458.1  T-complex protein 1 subunit zeta-2 isoform 2

      See identical proteins and their annotated locations for NP_001180458.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AK301773, DB032371
      Consensus CDS
      CCDS54106.1
      UniProtKB/Swiss-Prot
      Q92526
      Related
      ENSP00000398044.3, ENST00000421975.7
      Conserved Domains (2) summary
      cd03342
      Location:23 → 489
      TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
      TIGR02347
      Location:3 → 493
      chap_CCT_zeta; T-complex protein 1, zeta subunit

    2. NM_001193530.2 → NP_001180459.1  T-complex protein 1 subunit zeta-2 isoform 3

      See identical proteins and their annotated locations for NP_001180459.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AK301773, AK302344, BC027591, DB032371
      Consensus CDS
      CCDS54105.1
      UniProtKB/Swiss-Prot
      Q92526
      Related
      ENSP00000400917.3, ENST00000436961.7
      Conserved Domains (2) summary
      cd03342
      Location:23 → 481
      TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
      TIGR02347
      Location:3 → 485
      chap_CCT_zeta; T-complex protein 1, zeta subunit

    3. NM_006584.4 → NP_006575.2  T-complex protein 1 subunit zeta-2 isoform 1

      See identical proteins and their annotated locations for NP_006575.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK301773, BC026125, DB032371
      Consensus CDS
      CCDS32617.1
      UniProtKB/Swiss-Prot
      B4DX20, B4DYB0, Q8TC34, Q92526
      Related
      ENSP00000327191.5, ENST00000314144.10
      Conserved Domains (2) summary
      cd03342
      Location:23 → 526
      TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
      TIGR02347
      Location:3 → 530
      chap_CCT_zeta; T-complex protein 1, zeta subunit

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      34927861..34961460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      35874857..35908474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92526.5 GenPept UniProtKB/Swiss-Prot:Q92526

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