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    tsen-2 tRNA-intron lyase [ Caenorhabditis elegans ]

    Gene ID: 176619, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tsen-2
    Official Full Name
    tRNA-intron lyase
    Primary source
    WormBase:WBGene00013231
    Locus tag
    CELE_Y56A3A.11
    See related
    AllianceGenome:WB:WBGene00013231
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable tRNA-intron endonuclease activity. Predicted to be involved in tRNA-type intron splice site recognition and cleavage. Predicted to be located in nucleus. Predicted to be part of tRNA-intron endonuclease complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2B. Orthologous to human TSEN2 (tRNA splicing endonuclease subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tsen-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (11894793..11898269, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Amidase domain-containing protein Neighboring gene ncRNA Neighboring gene RRM domain-containing protein Neighboring gene Monoglyceride lipase faah-4 Neighboring gene F-box associated domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA ligation in neurons by RtcB inhibits axon regeneration. Kosmaczewski SG, et al. Proc Natl Acad Sci U S A, 2015 Jul 7. PMID 26100902, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-intron endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-intron endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA splicing, via endonucleolytic cleavage and ligation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA-type intron splice site recognition and cleavage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of tRNA-intron endonuclease complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA-intron lyase
    NP_499543.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11894793..11898269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067142.9 → NP_499543.2  tRNA-intron lyase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499543.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U218
      Conserved Domains (1) summary
      pfam01974
      Location:163 → 235
      tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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