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    ACL acetone-cyanohydrin lyase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816892, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ACL
    Official Full Name
    acetone-cyanohydrin lyase
    Primary source
    TAIR:AT2G23600
    Locus tag
    AT2G23600
    See related
    Araport:AT2G23600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    acetone-cyanohydrin lyase; ACETONE-CYANOHYDRIN LYASE; ARABIDOPSIS METHYL ESTERASE 8; ARABIDOPSIS THALIANA METHYL ESTERASE 2; ATME8; ATMES2; F26B6.25; F26B6_25; ME8; MES2; METHYL ESTERASE 2; METHYL ESTERASE 8
    Summary
    Encodes a protein shown to have carboxylesterase activity, methyl salicylate esterase activity, methyl jasmonate esterase activity, and methyl IAA esterase activity in vitro. MES2 appears to be involved in MeSA hydrolysis in planta. This protein does not act on MeGA4, or MEGA9 in vitro.
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    Genomic context

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    See ACL in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Sequence:
    Chromosome: 2; NC_003071.7 (10041820..10043840, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene methyl esterase 8 Neighboring gene ncRNA Neighboring gene methyl esterase 3 Neighboring gene methyl esterase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MeNA, Controlled by Reversible Methylation of Nicotinate, Is an NAD Precursor that Undergoes Long-Distance Transport in Arabidopsis. Wu R, et al. Mol Plant, 2018 Oct 8. PMID 30055263
    2. Identification of likely orthologs of tobacco salicylic acid-binding protein 2 and their role in systemic acquired resistance in Arabidopsis thaliana. Vlot AC, et al. Plant J, 2008 Nov. PMID 18643994
    3. Inactive methyl indole-3-acetic acid ester can be hydrolyzed and activated by several esterases belonging to the AtMES esterase family of Arabidopsis. Yang Y, et al. Plant Physiol, 2008 Jul. PMID 18467465, Free PMC Article
    4. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001335857.1
    NM_127924.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables carboxylesterase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity, acting on ester bonds IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyl indole-3-acetate esterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyl jasmonate esterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyl salicylate esterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within nicotinate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oxylipin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within salicylic acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    acetone-cyanohydrin lyase
    NP_179941.1
    • acetone-cyanohydrin lyase (ACL); FUNCTIONS IN: hydrolase activity, hydrolase activity, acting on ester bonds, methyl salicylate esterase activity, methyl jasmonate esterase activity, methyl indole-3-acetate esterase activity; INVOLVED IN: salicylic acid metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: guard cell, leaf; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Alpha/beta hydrolase fold-1 (InterPro:IPR000073); BEST Arabidopsis thaliana protein match is: methyl esterase 1 (TAIR:AT2G23620.1); Has 1952 Blast hits to 1950 proteins in 444 species: Archae - 0; Bacteria - 1129; Metazoa - 7; Fungi - 27; Plants - 629; Viruses - 0; Other Eukaryotes - 160 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      10041820..10043840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001335856.1 → NP_001323663.1  acetone-cyanohydrin lyase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VS91, A0A1P8AXQ5

    2. NM_127924.3 → NP_179941.1  acetone-cyanohydrin lyase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179941.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80476, Q8LCI0
      UniProtKB/TrEMBL
      A0A178VS91
      Conserved Domains (2) summary
      PLN02211
      Location:1 → 251
      PLN02211; methyl indole-3-acetate methyltransferase
      cl21494
      Location:9 → 256
      Abhydrolase; alpha/beta hydrolases

    3. NM_001335857.1 → NP_001323664.1  acetone-cyanohydrin lyase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AXW0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O80476.1

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