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    CG15093 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37166, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG15093provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034390
    Locus tag
    Dmel_CG15093
    See related
    AllianceGenome:FB:FBgn0034390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG 15093; CT34968; Dmel\CG15093
    Summary
    Predicted to enable 3-hydroxyisobutyrate dehydrogenase activity. Predicted to be involved in valine catabolic process. Located in mitochondrion. Is expressed in adult head; adult heart; and organism. Used to study amino acid metabolic disorder. Orthologous to human HIBADH (3-hydroxyisobutyrate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG15093 in Genome Data Viewer
    Location:
    55F2-55F2; 2-86 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18775669..18776978, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14663174..14664483, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 12b2 Neighboring gene jabba Neighboring gene Multiple C2 domain and transmembrane region protein Neighboring gene transfer RNA:Leucine-AAG 1-4 Neighboring gene antisense RNA:CR43964 Neighboring gene uncharacterized protein Neighboring gene Major Facilitator Superfamily Transporter 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Study of tauopathies by comparing Drosophila and human tau in Drosophila. Chen X, et al. Cell Tissue Res, 2007 Jul. PMID 17406902
    2. Fine-mapping nicotine resistance loci in Drosophila using a multiparent advanced generation inter-cross population. Marriage TN, et al. Genetics, 2014 Sep. PMID 25236448, Free PMC Article
    3. Elevation of glutamine level by selenophosphate synthetase 1 knockdown induces megamitochondrial formation in Drosophila cells. Shim MS, et al. J Biol Chem, 2009 Nov 20. PMID 19755423, Free PMC Article
    4. The ups and downs of daily life: profiling circadian gene expression in Drosophila. Etter PD, et al. Bioessays, 2002 Jun. PMID 12111731
    5. Identifying potential dietary treatments for inherited metabolic disorders using Drosophila nutrigenomics. Martelli F, et al. Cell Rep, 2024 Mar 26. PMID 38416643, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3-hydroxyisobutyrate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-hydroxyisobutyrate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3-hydroxyisobutyrate dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in valine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in valine catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    3-hydroxyisobutyrate dehydrogenase
    CG15093-PA
    CG15093-PB
    CG15093-PE
    NP_001188972.1
    NP_611373.1
    NP_725824.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18775669..18776978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137529.4 → NP_611373.1  uncharacterized protein Dmel_CG15093, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611373.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E926, Q86R98, Q9V8M5, Q9V8M6
      UniProtKB/TrEMBL
      A0A0B4JCU8
      Related
      FBpp0085821
      Conserved Domains (3) summary
      TIGR01692
      Location:33 → 318
      HIBADH; 3-hydroxyisobutyrate dehydrogenase
      pfam03446
      Location:29 → 187
      NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase
      pfam14833
      Location:190 → 314
      NAD_binding_11; NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase

    2. NM_001202043.2 → NP_001188972.1  uncharacterized protein Dmel_CG15093, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188972.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E926, Q86R98, Q9V8M5, Q9V8M6
      UniProtKB/TrEMBL
      A0A0B4JCU8
      Conserved Domains (3) summary
      TIGR01692
      Location:33 → 318
      HIBADH; 3-hydroxyisobutyrate dehydrogenase
      pfam03446
      Location:29 → 187
      NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase
      pfam14833
      Location:190 → 314
      NAD_binding_11; NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase

    3. NM_166306.3 → NP_725824.1  uncharacterized protein Dmel_CG15093, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725824.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E926, Q86R98, Q9V8M5, Q9V8M6
      UniProtKB/TrEMBL
      A0A0B4JCU8
      Related
      FBpp0085822
      Conserved Domains (3) summary
      TIGR01692
      Location:33 → 318
      HIBADH; 3-hydroxyisobutyrate dehydrogenase
      pfam03446
      Location:29 → 187
      NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase
      pfam14833
      Location:190 → 314
      NAD_binding_11; NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JCU8 A0A0B4JCU8
    Q9V8M5.2 Q9V8M5

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