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    CCT3 Chaperonin containing TCP1 subunit 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42029, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CCT3provided by FlyBase
    Official Full Name
    Chaperonin containing TCP1 subunit 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0015019
    Locus tag
    Dmel_CG8977
    See related
    AllianceGenome:FB:FBgn0015019
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cct-gamma; Cct-gamma; cct3; Cct3; cctg; Cctg; cctgamma; Cctgamma; CCTgamma; CG8977; Dmel\CG8977; geneY; Tcp-1-gamma; Tcp-1gamma; Tcp1-gamma; TCP1-gamma; TCPG_DROME; vine; Y
    Summary
    Predicted to enable unfolded protein binding activity. Involved in lumen formation, open tracheal system and terminal branching, open tracheal system. Predicted to be part of chaperonin-containing T-complex. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; germline cell; gut section; and larval muscle cell. Used to study intrinsic cardiomyopathy. Orthologous to human CCT3 (chaperonin containing TCP1 subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CCT3 in Genome Data Viewer
    Location:
    89D6-89D6; 3-59 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16647605..16649978)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12473327..12475700)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene nonA-like Neighboring gene ADP-ribosylation factor-like 6 interacting protein 1 Neighboring gene uncharacterized protein Neighboring gene Methyltransferase like 4 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila gene collection: identification of putative full-length cDNAs for 70% of D. melanogaster genes. Stapleton M, et al. Genome Res, 2002 Aug. PMID 12176937, Free PMC Article
    2. Miles to go (mtgo) encodes FNDC3 proteins that interact with the chaperonin subunit CCT3 and are required for NMJ branching and growth in Drosophila. Syed A, et al. Dev Biol, 2019 Jan 1. PMID 30539716, Free PMC Article
    3. Drosophila melanogaster P1 genomic clone DS05563 contains the chaperonin-encoding gene Cctg. Walkley NA, et al. Gene, 1996 Jun 1. PMID 8666276
    4. CCT and Cullin1 Regulate the TORC1 Pathway to Promote Dendritic Arborization in Health and Disease. Lottes EN, et al. Cells, 2024 Jun 13. PMID 38920658, Free PMC Article
    5. TRiC/CCT chaperonins are essential for maintaining myofibril organization, cardiac physiological rhythm, and lifespan. Melkani GC, et al. FEBS Lett, 2017 Nov. PMID 28963798, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lumen formation, open tracheal system HMP PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in terminal branching, open tracheal system HMP PubMed 
    Component Evidence Code Pubs
    part_of chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chaperonin-containing T-complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chaperonin containing TCP1 subunit 3
    Names
    CCT-gamma protein
    CCT3-PA
    CCT3-PB
    CCT3-PC
    CCT3-PD
    CCTgamma-like
    CG8977-PA
    CG8977-PB
    CG8977-PC
    CG8977-PD
    TCP-1 subunit 3gamma
    cctgamma
    chaperonin-containing t-complex protein-1 gamma subunit like
    predicted gene Y
    vine

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16647605..16649978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169727.2 → NP_732167.1  chaperonin containing TCP1 subunit 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732167.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48605, Q9VER9
      UniProtKB/TrEMBL
      A4V303
      Related
      FBpp0082788
      Conserved Domains (2) summary
      cd03337
      Location:7 → 524
      TCP1_gamma; TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
      TIGR02344
      Location:7 → 528
      chap_CCT_gamma; T-complex protein 1, gamma subunit

    2. NM_001202307.2 → NP_001189236.1  chaperonin containing TCP1 subunit 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189236.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48605, Q9VER9
      UniProtKB/TrEMBL
      A4V303
      Conserved Domains (2) summary
      cd03337
      Location:7 → 524
      TCP1_gamma; TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
      TIGR02344
      Location:7 → 528
      chap_CCT_gamma; T-complex protein 1, gamma subunit

    3. NM_001202308.2 → NP_001189237.1  chaperonin containing TCP1 subunit 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189237.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48605, Q9VER9
      UniProtKB/TrEMBL
      A4V303
      Conserved Domains (2) summary
      cd03337
      Location:7 → 524
      TCP1_gamma; TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
      TIGR02344
      Location:7 → 528
      chap_CCT_gamma; T-complex protein 1, gamma subunit

    4. NM_142315.4 → NP_650572.2  chaperonin containing TCP1 subunit 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650572.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48605, Q9VER9
      UniProtKB/TrEMBL
      A4V303
      Related
      FBpp0082787
      Conserved Domains (2) summary
      cd03337
      Location:7 → 524
      TCP1_gamma; TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
      TIGR02344
      Location:7 → 528
      chap_CCT_gamma; T-complex protein 1, gamma subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V303 A4V303
    P48605.2 P48605

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