U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    RBBP7 RB binding protein 7, chromatin remodeling factor [ Homo sapiens (human) ]

    Gene ID: 5931, updated on 9-Dec-2024

    Summary

    Official Symbol
    RBBP7provided by HGNC
    Official Full Name
    RB binding protein 7, chromatin remodeling factorprovided by HGNC
    Primary source
    HGNC:HGNC:9890
    See related
    Ensembl:ENSG00000102054 MIM:300825; AllianceGenome:HGNC:9890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RbAp46
    Summary
    This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
    Expression
    Ubiquitous expression in adrenal (RPKM 151.2), testis (RPKM 63.0) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RBBP7 in Genome Data Viewer
    Location:
    Xp22.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (16844341..16870362, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (16426872..16452877, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (16862464..16888485, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene taxilin gamma Neighboring gene ribosomal protein L12 pseudogene 49 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:16844989-16845504 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:16846635-16847134 Neighboring gene uncharacterized LOC124905251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29456 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20682 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:16888501-16889179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29457 Neighboring gene RNA, U4 small nuclear 6, pseudogene Neighboring gene SLC35C2 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The SIN3/HDAC complex, composed of SIN3A, SAP30, SAP18, HDAC-1 AND -2 and RbAp46/48 except SAP30, is identified to interact with HIV-1 Tat in Jurkat cell PubMed
    Vpr vpr HIV-1 Vpr forms a complex by recruiting RbAp46, HAT1, ZIP/sZIP, and Cul4A PubMed
    vpr HIV-1 Vpr is identified to have a physical interaction with retinoblastoma binding protein 7 (RBBP7) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC138867, MGC138868

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in brain development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cellular heat acclimation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell migration NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of stem cell population maintenance NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of stem cell population maintenance NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell fate specification NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of stem cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in response to steroid hormone IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of ATPase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ESC/E(Z) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ESC/E(Z) complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of NURF complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of NuRD complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of NuRD complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of NuRD complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of Sin3-type complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    part_of histone deacetylase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    histone-binding protein RBBP7
    Names
    G1/S transition control protein-binding protein RbAp46
    RBBP-7
    histone acetyltransferase type B subunit 2
    nucleosome-remodeling factor subunit RBAP46
    retinoblastoma-binding protein 7
    retinoblastoma-binding protein RbAp46
    retinoblastoma-binding protein p46

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198719.2NP_001185648.1  histone-binding protein RBBP7 isoform 1

      See identical proteins and their annotated locations for NP_001185648.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK091911, AL929302, BQ775345, DA924163
      Consensus CDS
      CCDS56598.1
      UniProtKB/TrEMBL
      A8K6A2
      Related
      ENSP00000369424.4, ENST00000380084.8
      Conserved Domains (3) summary
      sd00039
      Location:171218
      7WD40; WD40 repeat [structural motif]
      pfam12265
      Location:62131
      CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
      cl29593
      Location:166446
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_002893.4NP_002884.1  histone-binding protein RBBP7 isoform 2

      See identical proteins and their annotated locations for NP_002884.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL929302, BC114501, CN414343, DB460068
      Consensus CDS
      CCDS14179.1
      UniProtKB/Swiss-Prot
      Q16576, Q5JP00
      UniProtKB/TrEMBL
      A8K6A2, Q6FHQ0
      Related
      ENSP00000369427.3, ENST00000380087.7
      Conserved Domains (3) summary
      sd00039
      Location:127174
      7WD40; WD40 repeat [structural motif]
      pfam12265
      Location:1887
      CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
      cl29593
      Location:122402
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      16844341..16870362 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442292.1XP_047298248.1  histone-binding protein RBBP7 isoform X2

      UniProtKB/TrEMBL
      A8K6A2
    2. XM_047442291.1XP_047298247.1  histone-binding protein RBBP7 isoform X1

      UniProtKB/TrEMBL
      A8K6A2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      16426872..16452877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327470.1XP_054183445.1  histone-binding protein RBBP7 isoform X2

      UniProtKB/TrEMBL
      A8K6A2
    2. XM_054327469.1XP_054183444.1  histone-binding protein RBBP7 isoform X1

      UniProtKB/TrEMBL
      A8K6A2