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    Stag3 STAG3 cohesin complex component [ Mus musculus (house mouse) ]

    Gene ID: 50878, updated on 9-Dec-2024

    Summary

    Official Symbol
    Stag3provided by MGI
    Official Full Name
    STAG3 cohesin complex componentprovided by MGI
    Primary source
    MGI:MGI:1355311
    See related
    Ensembl:ENSMUSG00000036928 AllianceGenome:MGI:1355311
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SA-2
    Summary
    Predicted to enable chromatin binding activity. Acts upstream of or within homologous chromosome pairing at meiosis and protein localization to chromosome. Located in lateral element; male germ cell nucleus; and transverse filament. Part of meiotic cohesin complex. Is expressed in bone marrow; brain; and genitourinary system. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 8 and spermatogenic failure 61. Orthologous to human STAG3 (STAG3 cohesin complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 51.9), CNS E18 (RPKM 4.9) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Stag3 in Genome Data Viewer
    Location:
    5 G2; 5 77.01 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138270757..138310659)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138272514..138312397)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E532 Neighboring gene RIKEN cDNA 6330418K02 gene Neighboring gene STARR-positive B cell enhancer ABC_E4800 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 Neighboring gene trafficking protein particle complex 14 Neighboring gene galactose-3-O-sulfotransferase 4 Neighboring gene STARR-positive B cell enhancer ABC_E3630 Neighboring gene glypican 2 cerebroglycan Neighboring gene poliovirus receptor related immunoglobulin domain containing, pseudogene Neighboring gene poliovirus receptor related immunoglobulin domain containing Neighboring gene glutamatic-oxaloacetic transaminase 2, mitochondrial, pseudogene 1 Neighboring gene predicted gene 10874

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4) 
    • Transgenic (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lateral element IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of meiotic cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of meiotic cohesin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of meiotic cohesin complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in transverse filament IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cohesin subunit SA-3
    Names
    SCC3 homolog 3
    stromal antigen 3
    stromalin-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016964.2NP_058660.2  cohesin subunit SA-3

      See identical proteins and their annotated locations for NP_058660.2

      Status: VALIDATED

      Source sequence(s)
      AJ005678, BC060184
      Consensus CDS
      CCDS39344.1
      UniProtKB/Swiss-Prot
      B2RSV0, O70576
      Related
      ENSMUSP00000040945.9, ENSMUST00000048028.15
      Conserved Domains (1) summary
      pfam08514
      Location:188296
      STAG; STAG domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      138270757..138310659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240948.4XP_011239250.1  cohesin subunit SA-3 isoform X1

      See identical proteins and their annotated locations for XP_011239250.1

      UniProtKB/Swiss-Prot
      B2RSV0, O70576
      Conserved Domains (1) summary
      pfam08514
      Location:188296
      STAG; STAG domain
    2. XM_006504596.4XP_006504659.1  cohesin subunit SA-3 isoform X1

      See identical proteins and their annotated locations for XP_006504659.1

      UniProtKB/Swiss-Prot
      B2RSV0, O70576
      Conserved Domains (1) summary
      pfam08514
      Location:188296
      STAG; STAG domain
    3. XM_017320971.3XP_017176460.1  cohesin subunit SA-3 isoform X3

      Conserved Domains (1) summary
      pfam08514
      Location:188296
      STAG; STAG domain
    4. XM_017320972.3XP_017176461.1  cohesin subunit SA-3 isoform X3

      Conserved Domains (1) summary
      pfam08514
      Location:188296
      STAG; STAG domain
    5. XM_006504601.1XP_006504664.1  cohesin subunit SA-3 isoform X2

      See identical proteins and their annotated locations for XP_006504664.1

    6. XM_006504600.1XP_006504663.1  cohesin subunit SA-3 isoform X2

      See identical proteins and their annotated locations for XP_006504663.1

    RNA

    1. XR_004942532.1 RNA Sequence

    2. XR_377146.4 RNA Sequence