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    SP Sex Peptide [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39494, updated on 17-Dec-2024

    Summary

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    Official Symbol
    SPprovided by FlyBase
    Official Full Name
    Sex Peptideprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003034
    Locus tag
    Dmel_CG17673
    See related
    AllianceGenome:FB:FBgn0003034
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ACP; Acp-70A; Acp70; Acp70a; Acp70A; ACP70A; Apc70A; CG17673; Dmel\CG17673; DmSP; DrmSP; mSP; PapB; sex peptide; sp; Sp; Spg70
    Summary
    Enables G protein-coupled receptor binding activity. Involved in several processes, including adult feeding behavior; negative regulation of female receptivity, post-mating; and regulation of egg-laying behavior. Located in extracellular space. Is expressed in male accessory gland. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    70A4-70A4; 3-40 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13301635..13301922)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13294735..13295022)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43911 Neighboring gene long non-coding RNA:CR44557 Neighboring gene long non-coding RNA:CR44555

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interspecific introgression reveals a role of male genital morphology during the evolution of reproductive isolation in Drosophila. Frazee SR, et al. Evolution, 2021 May. PMID 33433903, Free PMC Article
    2. Sex peptide receipt alters macronutrient utilization but not optimal yeast-sugar ratio in Drosophila melanogaster females. Koppik M, et al. J Insect Physiol, 2022 May-Jun. PMID 35318041
    3. Mating-increases trypsin in female Drosophila hemolymph. Pilpel N, et al. Insect Biochem Mol Biol, 2008 Mar. PMID 18252246
    4. The benefits of male ejaculate sex peptide transfer in Drosophila melanogaster. Fricke C, et al. J Evol Biol, 2009 Feb. PMID 19032499
    5. Variation in sex peptide expression in D. melanogaster. Smith DT, et al. Genet Res (Camb), 2009 Aug. PMID 19640319

    See all (267) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Decoupled evolution of the Sex Peptide gene family and Sex Peptide Receptor in Drosophilidae.
      Title: Decoupled evolution of the Sex Peptide gene family and Sex Peptide Receptor in Drosophilidae.
    2. Molecular evolution of the sex peptide network in Drosophila.
      Title: Molecular evolution of the sex peptide network in Drosophila.
    3. Drosophila Sex Peptide controls the assembly of lipid microcarriers in seminal fluid.
      Title: Drosophila Sex Peptide controls the assembly of lipid microcarriers in seminal fluid.
    4. Genotypes and their interaction effects on reproduction and mating-induced immune activation in Drosophila melanogaster.
      Title: Genotypes and their interaction effects on reproduction and mating-induced immune activation in Drosophila melanogaster.
    5. sex peptide enhances memory by acting on a single pair of serotonergic brain neurons, in which activation of the sex peptide receptor stimulates the cyclic adenosine monophosphate/protein kinase A pathway.
      Title: A sperm peptide enhances long-term memory in female Drosophila.
    6. Female lifetime reproductive success and lifespan were differently affected by sex peptide receipt indicating that female post-mating responses diverged among populations.
      Title: Divergence in sex peptide-mediated female post-mating responses in Drosophila melanogaster.
    7. Data show that female sleep is reduced by male-derived sex Peptide (SP) SP acting through the canonical sex peptide receptor (SPR) within the same neurons responsible for altering other postmating responses (PMRs).
      Title: Changes in Female Drosophila Sleep following Mating Are Mediated by SPSN-SAG Neurons.
    8. Results suggested that the SP/SPR-mediated post-mating responses was established in the lineage of the D. melanogaster species group.
      Title: Evolution of sex-peptide in Drosophila.
    9. Molecular Functions and Cross-Species Activity of Sex-Peptide in Drosophila
      Title: Visualizing Molecular Functions and Cross-Species Activity of Sex-Peptide in Drosophila.
    10. Results reveal a rather flexible sex peptide that lacks a compact folded structure in solution.
      Title: NMR studies of the solution conformation of the sex peptide from Drosophila melanogaster.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hormone activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adult feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multi-organism reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of female receptivity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of female receptivity, post-mating IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of egg-laying behavior IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of female receptivity, post-mating IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of female receptivity, post-mating IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of juvenile hormone biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular space HDA PubMed 
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sex peptide
    Names
    CG17673-PA
    DrmSP
    Paragonial-peptide-B
    SP-PA
    Sex-Peptide
    accessory gland peptide 70A
    accessory gland protein 70A
    accessory protein 70A
    sex peptide gene in 70
    sexpeptide

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13301635..13301922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079333.2 → NP_524057.2  Sex peptide [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524057.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18659, P05623, Q6VBF8, Q9VU54
      UniProtKB/TrEMBL
      E3W287, E3W289, E3W2F5
      Related
      FBpp0075572, FBtr0075836
      Conserved Domains (1) summary
      pfam08138
      Location:1 → 55
      Sex_peptide; Sex peptide (SP) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05623.1 P05623

    Gene LinkOut

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