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    KINESIN-13A P-loop containing nucleoside triphosphate hydrolases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820915, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KINESIN-13A
    Official Full Name
    P-loop containing nucleoside triphosphate hydrolases superfamily protein
    Primary source
    TAIR:AT3G16630
    Locus tag
    AT3G16630
    See related
    Araport:AT3G16630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATKINESIN-13A
    Summary
    Kinesin-13A localized to entire Golgi stacks. Involved in trichome development.
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    Genomic context

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    See KINESIN-13A in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Sequence:
    Chromosome: 3; NC_003074.8 (5662375..5667951, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene SNF2 domain-containing protein / helicase domain-containing protein / zinc finger protein-like protein Neighboring gene pentatricopeptide (PPR) repeat-containing protein Neighboring gene translocon outer complex protein 120 Neighboring gene translationally controlled tumor protein Neighboring gene Transducin/WD40 repeat-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtKinesin-13A is located on Golgi-associated vesicle and involved in vesicle formation/budding in Arabidopsis root-cap peripheral cells. Wei L, et al. BMC Plant Biol, 2009 Nov 25. PMID 19939242, Free PMC Article
    2. An internal motor kinesin is associated with the Golgi apparatus and plays a role in trichome morphogenesis in Arabidopsis. Lu L, et al. Mol Biol Cell, 2005 Feb. PMID 15574882, Free PMC Article
    3. Rho of plant GTPase signaling regulates the behavior of Arabidopsis kinesin-13A to establish secondary cell wall patterns. Oda Y, et al. Plant Cell, 2013 Nov. PMID 24280391, Free PMC Article
    4. Atkinesin-13A modulates cell-wall synthesis and cell expansion in Arabidopsis thaliana via the THESEUS1 pathway. Fujikura U, et al. PLoS Genet, 2014 Sep. PMID 25232944, Free PMC Article
    5. RIP3 and AtKinesin-13A - a novel interaction linking Rho proteins of plants to microtubules. Mucha E, et al. Eur J Cell Biol, 2010 Dec. PMID 20832900

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kinesin-13A plays a central role in microtubule disassembly via the active ROP-MIDD1 cascade, which establishes the secondary cell wall pattern in metaxylem vessel cells.
      Title: Rho of plant GTPase signaling regulates the behavior of Arabidopsis kinesin-13A to establish secondary cell wall patterns.
    2. We show that RIP3 is localized at microtubules and interacts with the kinesin-13 family member AtKinesin-13A, suggesting a role for RIP3 in microtubule reorganization and a possible function in ROP-regulated polar growth.
      Title: RIP3 and AtKinesin-13A - a novel interaction linking Rho proteins of plants to microtubules.
    3. AtKinesin-13A decorates Golgi-associated vesicles and may be involved in regulating the formation of Golgi vesicles in the root-cap peripheral cells.
      Title: AtKinesin-13A is located on Golgi-associated vesicle and involved in vesicle formation/budding in Arabidopsis root-cap peripheral cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_112536.3
    NM_180267.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in metaxylem development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in plant-type secondary cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell wall organization or biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within trichome morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in trichome morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in secondary cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    P-loop containing nucleoside triphosphate hydrolases superfamily protein
    NP_188285.1
    • KINESIN-13A; FUNCTIONS IN: microtubule motor activity, ATP binding; INVOLVED IN: trichome morphogenesis; LOCATED IN: Golgi stack, plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Kinesin, motor region, conserved site (InterPro:IPR019821), Kinesin, motor domain (InterPro:IPR001752); BEST Arabidopsis thaliana protein match is: ATP binding microtubule motor family protein (TAIR:AT3G16060.1); Has 9822 Blast hits to 9510 proteins in 307 species: Archae - 4; Bacteria - 2; Metazoa - 4284; Fungi - 1351; Plants - 1799; Viruses - 0; Other Eukaryotes - 2382 (source: NCBI BLink).
    NP_850598.1
    • KINESIN-13A; FUNCTIONS IN: microtubule motor activity, ATP binding; INVOLVED IN: trichome morphogenesis; LOCATED IN: Golgi stack, plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Kinesin, motor region, conserved site (InterPro:IPR019821), Kinesin, motor domain (InterPro:IPR001752); BEST Arabidopsis thaliana protein match is: ATP binding microtubule motor family protein (TAIR:AT3G16060.1); Has 9814 Blast hits to 9502 proteins in 306 species: Archae - 4; Bacteria - 2; Metazoa - 4282; Fungi - 1345; Plants - 1799; Viruses - 0; Other Eukaryotes - 2382 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      5662375..5667951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112536.3 → NP_188285.1  P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188285.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56WU1, Q940B8, Q9LUS1
      UniProtKB/TrEMBL
      A0A178VP70, A0A5S9XCS7, A0A7G2EMH9
      Conserved Domains (2) summary
      cd01367
      Location:193 → 524
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
      cl15755
      Location:29 → 84
      SAM_superfamily; SAM (Sterile alpha motif )

    2. NM_180267.2 → NP_850598.1  P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850598.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56WU1, Q940B8, Q9LUS1
      UniProtKB/TrEMBL
      A0A178VP70, A0A5S9XCS7, A0A7G2EMH9
      Conserved Domains (2) summary
      cd01367
      Location:193 → 524
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
      cl15755
      Location:29 → 84
      SAM_superfamily; SAM (Sterile alpha motif )
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q940B8.1

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