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    RPP5 Disease resistance protein (TIR-NBS-LRR class) family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827403, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RPP5
    Official Full Name
    Disease resistance protein (TIR-NBS-LRR class) family
    Primary source
    TAIR:AT4G16950
    Locus tag
    AT4G16950
    See related
    Araport:AT4G16950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DISEASE RESISTANCE PROTEIN RPP5; DL4505C; FCAALL.315; RECOGNITION OF PERONOSPORA PARASITICA 5
    Summary
    Contains a putative nucleotide binding site and leucine-rich repeats. Similar to the plant resistance genes N and L6, and to the toll and interleukin-1 receptors. Confers resistance to Peronospora parasitica.
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    Genomic context

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    See RPP5 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    7
    Sequence:
    Chromosome: 4; NC_003075.7 (9538233..9544755, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Disease resistance protein (TIR-NBS-LRR class) family Neighboring gene miscRNA Neighboring gene uncharacterized protein Neighboring gene SUPPRESSOR OF, CONSTITUTIVE protein Neighboring gene disease resistance protein (TIR-NBS-LRR class) Neighboring gene Protein kinase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis downy mildew resistance gene RPP5 shares similarity to the toll and interleukin-1 receptors with N and L6. Parker JE, et al. Plant Cell, 1997 Jun. PMID 9212464, Free PMC Article
    2. A novel cost of R gene resistance in the presence of disease. Korves T, et al. Am Nat, 2004 Apr. PMID 15122498
    3. Plant disease resistance genes encode members of an ancient and diverse protein family within the nucleotide-binding superfamily. Meyers BC, et al. Plant J, 1999 Nov. PMID 10571892
    4. Pronounced intraspecific haplotype divergence at the RPP5 complex disease resistance locus of Arabidopsis. Noël L, et al. Plant Cell, 1999 Nov. PMID 10559437, Free PMC Article
    5. Individual components of paired typical NLR immune receptors are regulated by distinct E3 ligases. Dong OX, et al. Nat Plants, 2018 Sep. PMID 30082764

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001341165.1
    NM_001341166.1
    NM_001341167.1
    NM_001341168.1
    NM_117798.4
    NM_179067.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Disease resistance protein (TIR-NBS-LRR class) family
    NP_193428.2
    • RECOGNITION OF PERONOSPORA PARASITICA 5 (RPP5); FUNCTIONS IN: nucleotide binding; INVOLVED IN: defense response to fungus, incompatible interaction, defense response; LOCATED IN: intrinsic to membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), NB-ARC (InterPro:IPR002182), Leucine-rich repeat (InterPro:IPR001611), Toll-Interleukin receptor (InterPro:IPR000157), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) family (TAIR:AT4G16920.1); Has 33222 Blast hits to 18539 proteins in 791 species: Archae - 22; Bacteria - 2185; Metazoa - 2568; Fungi - 207; Plants - 26793; Viruses - 32; Other Eukaryotes - 1415 (source: NCBI BLink).
    NP_849398.1
    • RECOGNITION OF PERONOSPORA PARASITICA 5 (RPP5); FUNCTIONS IN: nucleotide binding; INVOLVED IN: defense response to fungus, incompatible interaction, defense response; LOCATED IN: intrinsic to membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), NB-ARC (InterPro:IPR002182), Leucine-rich repeat (InterPro:IPR001611), Toll-Interleukin receptor (InterPro:IPR000157), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) family (TAIR:AT4G16920.1); Has 33205 Blast hits to 18535 proteins in 791 species: Archae - 22; Bacteria - 2185; Metazoa - 2566; Fungi - 207; Plants - 26778; Viruses - 32; Other Eukaryotes - 1415 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      9538233..9544755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117798.4 → NP_193428.2  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193428.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DG46, F4JNB7, O23535, Q0WV14
      Conserved Domains (7) summary
      cd09293
      Location:939 → 1092
      AMN1; Antagonist of mitotic exit network protein 1
      PLN03210
      Location:1 → 1348
      PLN03210; Resistant to P. syringae 6; Provisional
      sd00033
      Location:918 → 940
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:713 → 780
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam01582
      Location:12 → 178
      TIR; TIR domain
      pfam07725
      Location:597 → 615
      LRR_3; Leucine Rich Repeat
      cl21455
      Location:209 → 308
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001341165.1 → NP_001328022.1  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B3F3

    3. NM_001341166.1 → NP_001328019.1  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B3D0

    4. NM_179067.2 → NP_849398.1  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849398.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JNB8
      Conserved Domains (7) summary
      cd09293
      Location:939 → 1092
      AMN1; Antagonist of mitotic exit network protein 1
      PLN03210
      Location:1 → 1277
      PLN03210; Resistant to P. syringae 6; Provisional
      sd00033
      Location:918 → 940
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:713 → 780
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam01582
      Location:12 → 178
      TIR; TIR domain
      pfam07725
      Location:597 → 615
      LRR_3; Leucine Rich Repeat
      cl21455
      Location:209 → 308
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. NM_001341168.1 → NP_001328021.1  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B3F0, A0A346XQE5

    6. NM_001341167.1 → NP_001328020.1  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B3E1, A0A346XQE5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4JNB7.1

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