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    SOCS4 suppressor of cytokine signaling 4 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 696146, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SOCS4provided by VGNC
    Official Full Name
    suppressor of cytokine signaling 4provided by VGNC
    Primary source
    VGNC:VGNC:77741
    Locus tag
    EGK_18204
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See SOCS4 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (117135757..117153961)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (116988241..117006450)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene WD repeat and HMG-box DNA binding protein 1 Neighboring gene 60S ribosomal protein L31 pseudogene Neighboring gene 40S ribosomal protein SA-like Neighboring gene mitogen-activated protein kinase 1 interacting protein 1 like Neighboring gene small nucleolar RNA U3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of phosphatidylinositol 3-kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    suppressor of cytokine signaling 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193820.2 → NP_001180749.1  suppressor of cytokine signaling 4

      See identical proteins and their annotated locations for NP_001180749.1

      Status: PROVISIONAL

      Source sequence(s)
      QNVO02000421
      UniProtKB/TrEMBL
      A0A8J8YNV0, F6YVE7, H9ER10, H9Z1L1
      Conserved Domains (3) summary
      cd10385
      Location:275 → 375
      SH2_SOCS4; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03738
      Location:384 → 439
      SOCS_SOCS4; SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
      pfam12610
      Location:59 → 111
      SOCS; Suppressor of cytokine signalling

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      117135757..117153961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001087968.4 → XP_001087968.1  suppressor of cytokine signaling 4 isoform X1

      See identical proteins and their annotated locations for XP_001087968.1

      UniProtKB/TrEMBL
      A0A8J8YNV0, F6YVE7, H9ER10, H9Z1L1
      Conserved Domains (3) summary
      cd10385
      Location:275 → 375
      SH2_SOCS4; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03738
      Location:384 → 439
      SOCS_SOCS4; SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
      pfam12610
      Location:59 → 111
      SOCS; Suppressor of cytokine signalling

    2. XM_015143704.2 → XP_014999190.1  suppressor of cytokine signaling 4 isoform X1

      UniProtKB/TrEMBL
      A0A8J8YNV0, F6YVE7, H9ER10, H9Z1L1
      Conserved Domains (3) summary
      cd10385
      Location:275 → 375
      SH2_SOCS4; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03738
      Location:384 → 439
      SOCS_SOCS4; SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
      pfam12610
      Location:59 → 111
      SOCS; Suppressor of cytokine signalling

    3. XM_015143705.2 → XP_014999191.1  suppressor of cytokine signaling 4 isoform X1

      UniProtKB/TrEMBL
      A0A8J8YNV0, F6YVE7, H9ER10, H9Z1L1
      Conserved Domains (3) summary
      cd10385
      Location:275 → 375
      SH2_SOCS4; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03738
      Location:384 → 439
      SOCS_SOCS4; SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
      pfam12610
      Location:59 → 111
      SOCS; Suppressor of cytokine signalling
    Nucleotide Protein
    Heading Accession and Version

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