agap1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: agap1provided by Xenbase
Official Full Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 1provided by Xenbase
Primary source: Xenbase:XB-GENE-981023
See related: Ensembl:ENSXETG00000003280 AllianceGenome:Xenbase:XB-GENE-981023
Gene type: protein coding
RefSeq status: MODEL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: ggap1; centg2
Summary: Predicted to enable several functions, including GTP binding activity; GTPase activator activity; and GTPase activity. Orthologous to several human genes including AGAP1 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	9	NC_030685.2 (59549897..59792023)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	9	NC_030685.1 (54444130..54687433)

Chromosome 9 - NC_030685.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030685.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

59549897..59792023

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_004917871.4 → XP_004917928.1 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X4

UniProtKB/TrEMBL

A0A6I8SSI0, F6TBJ8

Related

ENSXETP00000097735.2, ENSXETT00000069579.2

Conserved Domains (8) summary

cd04103
Location:72 → 233

Centaurin_gamma; Centaurin gamma (CENTG) GTPase

smart00173
Location:73 → 239

RAS; Ras subfamily of RAS small GTPases

cd00204
Location:771 → 854

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01250
Location:348 → 624

PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain

pfam00169
Location:548 → 619

PH; PH domain

pfam01412
Location:643 → 757

ArfGap; Putative GTPase activating protein for Arf

pfam12796
Location:768 → 858

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:768 → 798

ANK; ANK repeat [structural motif]
XM_004917872.4 → XP_004917929.1 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X5

UniProtKB/TrEMBL

A0A8J0R4X3, F6TBJ8

Conserved Domains (8) summary

cd04103
Location:72 → 229

Centaurin_gamma; Centaurin gamma (CENTG) GTPase

smart00173
Location:73 → 235

RAS; Ras subfamily of RAS small GTPases

cd00204
Location:767 → 850

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01250
Location:344 → 620

PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain

pfam00169
Location:544 → 615

PH; PH domain

pfam01412
Location:639 → 753

ArfGap; Putative GTPase activating protein for Arf

pfam12796
Location:764 → 854

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:764 → 794

ANK; ANK repeat [structural motif]
XM_002931998.5 → XP_002932044.1 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X6

UniProtKB/TrEMBL

A0A8J0QHS3, F6TBJ8

Related

ENSXETP00000007118.5, ENSXETT00000007118.5

Conserved Domains (8) summary

cd04103
Location:72 → 229

Centaurin_gamma; Centaurin gamma (CENTG) GTPase

smart00173
Location:73 → 235

RAS; Ras subfamily of RAS small GTPases

cd00204
Location:742 → 825

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01250
Location:344 → 595

PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain

pfam00169
Location:347 → 411

PH; PH domain

pfam01412
Location:614 → 728

ArfGap; Putative GTPase activating protein for Arf

pfam12796
Location:739 → 829

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:739 → 769

ANK; ANK repeat [structural motif]
XM_004917868.4 → XP_004917925.2 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1

UniProtKB/TrEMBL

A0A5S6NXZ5, A0A6I8SFK2

Related

ENSXETP00000092067.2, ENSXETT00000092903.2

Conserved Domains (5) summary

cd04103
Location:382 → 543

Centaurin_gamma; Centaurin gamma (CENTG) GTPase

cd01250
Location:658 → 934

PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain

sd00045
Location:1078 → 1108

ANK; ANK repeat [structural motif]

cd08836
Location:953 → 1059

ArfGap_AGAP; ArfGAP with GTPase domain, ANK repeat and PH domains

pfam13857
Location:1093 → 1151

Ank_5; Ankyrin repeats (many copies)
XM_004917869.4 → XP_004917926.2 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X2

UniProtKB/TrEMBL

A0A5S6NXZ5, A0A6I8RJK7

Related

ENSXETP00000082038.2, ENSXETT00000089023.2

Conserved Domains (5) summary

cd04103
Location:382 → 539

Centaurin_gamma; Centaurin gamma (CENTG) GTPase

cd01250
Location:654 → 930

PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain

sd00045
Location:1074 → 1104

ANK; ANK repeat [structural motif]

cd08836
Location:949 → 1055

ArfGap_AGAP; ArfGAP with GTPase domain, ANK repeat and PH domains

pfam13857
Location:1089 → 1147

Ank_5; Ankyrin repeats (many copies)
XM_004917870.4 → XP_004917927.2 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X3

UniProtKB/TrEMBL

A0A5S6NXZ5, A0A6I8R0Y4

Related

ENSXETP00000074999.2, ENSXETT00000092487.2

Conserved Domains (5) summary

cd04103
Location:382 → 543

Centaurin_gamma; Centaurin gamma (CENTG) GTPase

cd01250
Location:658 → 909

PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain

sd00045
Location:1053 → 1083

ANK; ANK repeat [structural motif]

cd08836
Location:928 → 1034

ArfGap_AGAP; ArfGAP with GTPase domain, ANK repeat and PH domains

pfam13857
Location:1068 → 1126

Ank_5; Ankyrin repeats (many copies)