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    MRN1 marneral synthase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834267, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MRN1
    Official Full Name
    marneral synthase
    Primary source
    TAIR:AT5G42600
    Locus tag
    AT5G42600
    See related
    Araport:AT5G42600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    marneral synthase; marneral synthase 1; MFO20.1; MFO20_1
    Summary
    Encodes an oxidosqualene synthase that produces the monocyclic triterpene marneral. Crucial for growth and development.
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    Genomic context

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    See MRN1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    14
    Sequence:
    Chromosome: 5; NC_003076.8 (17053453..17058245)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene calcium uniporter (DUF607) Neighboring gene metalloendopeptidase / zinc ion binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of marneral synthase, which is critical for growth and development in Arabidopsis. Go YS, et al. Plant J, 2012 Dec. PMID 22882494
    2. An Arabidopsis oxidosqualene cyclase catalyzes iridal skeleton formation by Grob fragmentation. Xiong Q, et al. Angew Chem Int Ed Engl, 2006 Feb 13. PMID 16425307
    3. Formation of plant metabolic gene clusters within dynamic chromosomal regions. Field B, et al. Proc Natl Acad Sci U S A, 2011 Sep 20. PMID 21876149, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. triterpenoid pathway via marneral synthase is important for the growth and development of Arabidopsis
      Title: Identification of marneral synthase, which is critical for growth and development in Arabidopsis.
    2. Data show taht MRN1 (At5g42600) is flanked by two coexpressed cytochrome P450 genes that belong to different P450 families.
      Title: Formation of plant metabolic gene clusters within dynamic chromosomal regions.
    3. Results describe marneral synthase, an oxidosqualene cyclase that catalyzes iridal skeleton formation by Grob fragmentation.
      Title: An Arabidopsis oxidosqualene cyclase catalyzes iridal skeleton formation by Grob fragmentation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_123624.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables marneral synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within triterpenoid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    marneral synthase
    NP_199074.1
    • marneral synthase (MRN1); CONTAINS InterPro DOMAIN/s: Terpene synthase, conserved site (InterPro:IPR002365), Terpenoid cylases/protein prenyltransferase alpha-alpha toroid (InterPro:IPR008930), Squalene cyclase (InterPro:IPR018333), Prenyltransferase/squalene oxidase (InterPro:IPR001330); BEST Arabidopsis thaliana protein match is: Terpenoid cyclases family protein (TAIR:AT1G78500.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      17053453..17058245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123624.4 → NP_199074.1  marneral synthase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199074.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FJV8
      UniProtKB/TrEMBL
      A0A5S9YBF5
      Conserved Domains (1) summary
      PLN03012
      Location:1 → 752
      PLN03012; Camelliol C synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FJV8.1

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