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    APL2 ADPGLC-PPase large subunit [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839660, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APL2
    Official Full Name
    ADPGLC-PPase large subunit
    Primary source
    TAIR:AT1G27680
    Locus tag
    AT1G27680
    See related
    Araport:AT1G27680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ADPGLC-PPase large subunit; T22C5.13; T22C5_13
    Summary
    ADP-glucose pyrophosphorylase catalyzes the first, rate limiting step in starch biosynthesis. The large subunit plays a regulatory role whereas the small subunit (ApS) is the catalytic isoform. Four isoforms of the large subunit (ApL1-4) have been described.Mutational analysis of APS1 suggests that APL1 and APL2 can compensate for loss of APS1 catalytic activity,suggesting both have catalytic as well as regulatory functions.
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    Genomic context

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    See APL2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Sequence:
    Chromosome: 1; NC_003070.9 (9631190..9634597)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene miscRNA Neighboring gene lipase, putative (DUF620) Neighboring gene glycine-rich protein Neighboring gene Syntaxin/t-SNARE family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The different large subunit isoforms of Arabidopsis thaliana ADP-glucose pyrophosphorylase confer distinct kinetic and regulatory properties to the heterotetrameric enzyme. Crevillén P, et al. J Biol Chem, 2003 Aug 1. PMID 12748181
    2. Sugars and light/dark exposure trigger differential regulation of ADP-glucose pyrophosphorylase genes in Arabidopsis thaliana (thale cress). Sokolov LN, et al. Biochem J, 1998 Dec 15. PMID 9841881, Free PMC Article
    3. Molecular characterization of multiple cDNA clones for ADP-glucose pyrophosphorylase from Arabidopsis thaliana. Villand P, et al. Plant Mol Biol, 1993 Dec. PMID 8292792
    4. Two Arabidopsis ADP-glucose pyrophosphorylase large subunits (APL1 and APL2) are catalytic. Ventriglia T, et al. Plant Physiol, 2008 Sep. PMID 18614708, Free PMC Article
    5. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. may contribute to ADP-glucose synthesis
      Title: Two Arabidopsis ADP-glucose pyrophosphorylase large subunits (APL1 and APL2) are catalytic.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_102533.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glucose-1-phosphate adenylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucose-1-phosphate adenylyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in starch biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within starch biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ADPGLC-PPase large subunit
    NP_174089.1
    • ADPGLC-PPase large subunit (APL2); CONTAINS InterPro DOMAIN/s: Glucose-1-phosphate adenylyltransferase (InterPro:IPR011831), ADP-glucose pyrophosphorylase, conserved site (InterPro:IPR005836), Nucleotidyl transferase (InterPro:IPR005835); BEST Arabidopsis thaliana protein match is: Glucose-1-phosphate adenylyltransferase family protein (TAIR:AT4G39210.1); Has 11860 Blast hits to 11712 proteins in 2161 species: Archae - 516; Bacteria - 8154; Metazoa - 62; Fungi - 36; Plants - 1704; Viruses - 0; Other Eukaryotes - 1388 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      9631190..9634597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102533.5 → NP_174089.1  ADPGLC-PPase large subunit [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174089.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P55230, Q9SFZ1
      UniProtKB/TrEMBL
      A0A178W595, A0A5S9W3A4
      Conserved Domains (1) summary
      PLN02241
      Location:82 → 518
      PLN02241; glucose-1-phosphate adenylyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55230.2

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