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    Coq4 Coenzyme Q4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 261607, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Coq4provided by FlyBase
    Official Full Name
    Coenzyme Q4provided by FlyBase
    Primary source
    FLYBASE:FBgn0052174
    Locus tag
    Dmel_CG32174
    See related
    AllianceGenome:FB:FBgn0052174
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32174; CG3877; Dmel\CG32174
    Summary
    Predicted to be involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be part of ubiquinone biosynthesis complex. Predicted to be active in mitochondrion. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 7 and spastic ataxia. Orthologous to human COQ4 (coenzyme Q4). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See Coq4 in Genome Data Viewer
    Location:
    74B5-74C1; 3-45 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17428936..17433621, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17422036..17426721, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene RNA polymerase III subunit G Neighboring gene Golgin, RAB6 interacting Neighboring gene fringe connection Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Personalized Model of COQ2 Nephropathy Rescued by the Wild-Type COQ2 Allele or Dietary Coenzyme Q(10) Supplementation. Zhu JY, et al. J Am Soc Nephrol, 2017 Sep. PMID 28428331, Free PMC Article
    2. In vivo screening reveals interactions between Drosophila Manf and genes involved in the mitochondria and the ubiquinone synthesis pathway. Lindström R, et al. BMC Genet, 2017 Jun 2. PMID 28578657, Free PMC Article
    3. Selection for cold resistance alters gene transcript levels in Drosophila melanogaster. Telonis-Scott M, et al. J Insect Physiol, 2009 Jun. PMID 19232407
    4. Expression-Based Cell Lineage Analysis in Drosophila Through a Course-Based Research Experience for Early Undergraduates. Olson JM, et al. G3 (Bethesda), 2019 Nov 5. PMID 31690598, Free PMC Article
    5. Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster. Weber AL, et al. PLoS One, 2012. PMID 22496853, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquinone biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquinone biosynthesis complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    coenzyme Q4
    Names
    CG32174-PB
    CG32174-PC
    CG32174-PD
    Coq4-PB
    Coq4-PC
    Coq4-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17428936..17433621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259886.1 → NP_001246815.1  coenzyme Q4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246815.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7Z065, Q9VVG6
      UniProtKB/TrEMBL
      E3CTI1, M9NDU8
      Conserved Domains (1) summary
      pfam05019
      Location:54 → 265
      Coq4; Coenzyme Q (ubiquinone) biosynthesis protein Coq4

    2. NM_168732.3 → NP_730270.1  coenzyme Q4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730270.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7Z065, Q9VVG6
      UniProtKB/TrEMBL
      E3CTI1, M9NDU8
      Related
      FBpp0074989
      Conserved Domains (1) summary
      pfam05019
      Location:54 → 265
      Coq4; Coenzyme Q (ubiquinone) biosynthesis protein Coq4

    3. NM_140720.5 → NP_648977.3  coenzyme Q4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648977.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7Z065, Q9VVG6
      UniProtKB/TrEMBL
      E3CTI1, M9NDU8
      Conserved Domains (1) summary
      pfam05019
      Location:54 → 265
      Coq4; Coenzyme Q (ubiquinone) biosynthesis protein Coq4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NDU8 M9NDU8
    Q9VVG6.3 Q9VVG6

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