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    Ufm1 Ubiquitin-fold modifier 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740715, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ufm1provided by FlyBase
    Official Full Name
    Ubiquitin-fold modifier 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0085220
    Locus tag
    Dmel_CG34191
    See related
    AllianceGenome:FB:FBgn0085220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG34191; Dmel\CG34191; dUFM1; UFM1
    Summary
    Enables protein tag activity. Involved in neuromuscular process and protein ufmylation. Is active in cytosol. Is expressed in adult head. Used to study autosomal recessive cerebellar ataxia. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 14. Orthologous to human UFM1 (ubiquitin fold modifier 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ufm1 in Genome Data Viewer
    Location:
    53E2-53E2; 2-81 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16951837..16952581)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12839342..12840086)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Vacuolar H[+] ATPase 16kD subunit 4 Neighboring gene muscle wasted Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class V Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The UFM1 cascade times mitosis entry associated with microcephaly. Yu L, et al. FASEB J, 2020 Jan. PMID 31914610
    2. Urm1: an essential regulator of JNK signaling and oxidative stress in Drosophila melanogaster. Khoshnood B, et al. Cell Mol Life Sci, 2016 May. PMID 26715182, Free PMC Article
    3. UBA5 Mutations Cause a New Form of Autosomal Recessive Cerebellar Ataxia. Duan R, et al. PLoS One, 2016. PMID 26872069, Free PMC Article
    4. A neuroprotective role of Ufmylation through Atg9 in the aging brain of Drosophila. Li H, et al. Cell Mol Life Sci, 2023 Apr 22. PMID 37086384, Free PMC Article
    5. SAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum. Wang L, et al. Cell Rep, 2023 Jan 31. PMID 36848233, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein tag activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neuromuscular process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ufmylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ufmylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in reticulophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Ubiquitin-fold modifier 1
    Names
    CG34191-PA
    CG34191-PB
    Ufm1-PA
    Ufm1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16951837..16952581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103884.4 → NP_001097354.1  Ubiquitin-fold modifier 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097354.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8DYH2, C9QNX3
      UniProtKB/TrEMBL
      A0A0B4LFP4
      Conserved Domains (1) summary
      cd01766
      Location:4 → 78
      Ubl_UFM1; ubiquitin-like (Ubl) domain found in ubiquitin fold modifier 1 (UFM1)

    2. NM_001299578.1 → NP_001286507.1  Ubiquitin-fold modifier 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286507.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8DYH2, C9QNX3
      UniProtKB/TrEMBL
      A0A0B4LFP4
      Conserved Domains (1) summary
      cd01766
      Location:4 → 78
      Ubl_UFM1; ubiquitin-like (Ubl) domain found in ubiquitin fold modifier 1 (UFM1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFP4 A0A0B4LFP4
    A8DYH2.1 A8DYH2

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