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    HGV1gp1 polyprotein precursor [ GB virus C ]

    Gene ID: 2700757, updated on 18-Aug-2023

    Summary

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    Gene symbol
    HGV1gp1
    Gene description
    polyprotein precursor
    Locus tag
    HGV1gp1
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    GB virus C
    Lineage
    Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes; Amarillovirales; Flaviviridae; Pegivirus; Pegivirus C
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    Genomic context

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    Sequence:
    NC_001710.1 (459..9080)

    NC_001710.1Genomic Context describing neighboring genes

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001710.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a peptide domain within the GB virus C envelope glycoprotein (E2) that inhibits HIV replication. Xiang J, et al. Virology, 2012 Aug 15. PMID 22608061, Free PMC Article
    2. GB virus type C interactions with HIV: the role of envelope glycoproteins. Mohr EL, et al. J Viral Hepat, 2009 Nov. PMID 19758271, Free PMC Article
    3. Characterization of a peptide domain within the GB virus C NS5A phosphoprotein that inhibits HIV replication. Xiang J, et al. PLoS One, 2008 Jul 2. PMID 18596910, Free PMC Article
    4. Hepatitis G virus encodes protease activities which can effect processing of the virus putative nonstructural proteins. Belyaev AS, et al. J Virol, 1998 Jan. PMID 9420302, Free PMC Article
    5. Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent. Linnen J, et al. Science, 1996 Jan 26. PMID 8560265

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NS3 protease of GB virus C cleaved MAVS but not TRIF, and it inhibited interferon responses sufficiently to enhance growth of an interferon-sensitive virus.
      Title: Human pegivirus (GB virus C) NS3 protease activity inhibits induction of the type I interferon response and is not inhibited by HCV NS3 protease inhibitors.
    2. These data identify the region of GB virus C E2 protein involved in HIV inhibition, and suggest that this GB virus C E2 peptide must gain entry into the cell to inhibit HIV.
      Title: Characterization of a peptide domain within the GB virus C envelope glycoprotein (E2) that inhibits HIV replication.
    3. GBV-C E2-mediated HIV inhibition is dose-dependent and HIV replication is blocked at the binding and/or entry step.
      Title: GB virus type C interactions with HIV: the role of envelope glycoproteins.
    4. Expression of GBV-C NS5A amino acids 152-165 are sufficient to inhibit HIV replication in vitro, and the serine at position 158 appears important for this effect through either phosphorylation or structural changes in this peptide.
      Title: Characterization of a peptide domain within the GB virus C NS5A phosphoprotein that inhibits HIV replication.
    Submit: New GeneRIF Correction

    General protein information

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    Preferred Names
    polyprotein precursor
    Names
    putative E1 protein
    putative E2 protein
    putative protein p7-NS2
    NS3 proteinase/ATPase/helicase
    putative NS4A protein
    putative NS4B protein
    putative NS5A protein
    putative NS5B RNA-dependent RNA polymerase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001710.1 Reference assembly

      Range
      459..9080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_043570.1 polyprotein precursor [GB virus C]

      See identical proteins and their annotated locations for NP_043570.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P89967, Q69431
      Conserved Domains (12) summary
      pfam01001
      Location:1653 → 1847
      HCV_NS4b; Hepatitis C virus non-structural protein NS4b
      pfam02907
      Location:955 → 1102
      Peptidase_S29; Hepatitis C virus NS3 protease
      pfam08301
      Location:1991 → 2089
      HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
      pfam12786
      Location:151 → 574
      GBV-C_env; GB virus C genotype envelope
      pfam01538
      Location:705 → 902
      HCV_NS2; Hepatitis C virus non-structural protein NS2
      smart00487
      Location:1123 → 1252
      DEXDc; DEAD-like helicases superfamily
      cd00046
      Location:1123 → 1250
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:1278 → 1340
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00998
      Location:2313 → 2806
      RdRP_3; Viral RNA dependent RNA polymerase
      pfam01006
      Location:1554 → 1598
      HCV_NS4a; Hepatitis C virus non-structural protein NS4a
      pfam01506
      Location:1897 → 1919
      HCV_NS5a; Hepatitis C virus non-structural 5a protein membrane anchor
      pfam08300
      Location:1927 → 1986
      HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain

    2. NP_803202.1 putative E1 protein

      Conserved Domains (1) summary
      pfam12786
      Location:151 → 360
      GBV-C_env; GB virus C genotype envelope

    3. NP_803203.1 putative E2 protein

      UniProtKB/TrEMBL
      D3GMT8
      Conserved Domains (1) summary
      pfam12786
      Location:1 → 214
      GBV-C_env; GB virus C genotype envelope

    4. NP_803204.1 putative protein p7-NS2

      Conserved Domains (1) summary
      pfam01538
      Location:33 → 230
      HCV_NS2; Hepatitis C virus non-structural protein NS2

    5. NP_803205.1 NS3 proteinase/ATPase/helicase

      Conserved Domains (4) summary
      pfam02907
      Location:30 → 177
      Peptidase_S29; Hepatitis C virus NS3 protease
      smart00487
      Location:198 → 327
      DEXDc; DEAD-like helicases superfamily
      cd00046
      Location:198 → 325
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:353 → 415
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

    6. NP_803206.1 putative NS4A protein

      Conserved Domains (1) summary
      pfam01006
      Location:3 → 38
      HCV_NS4a; Hepatitis C virus non-structural protein NS4a

    7. NP_803207.1 putative NS4B protein

      Conserved Domains (1) summary
      pfam01001
      Location:36 → 230
      HCV_NS4b; Hepatitis C virus non-structural protein NS4b

    8. NP_803208.1 putative NS5A protein

      UniProtKB/TrEMBL
      Q3LU44
      Conserved Domains (3) summary
      pfam08301
      Location:93 → 191
      HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
      pfam01506
      Location:1 → 21
      HCV_NS5a; Hepatitis C virus non-structural 5a protein membrane anchor
      pfam08300
      Location:29 → 88
      HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain

    9. NP_803209.1 putative NS5B RNA-dependent RNA polymerase

      Conserved Domains (1) summary
      pfam00998
      Location:3 → 496
      RdRP_3; Viral RNA dependent RNA polymerase
    Nucleotide Protein
    Heading Accession and Version

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