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    Ephrin ephrin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43799, updated on 17-Dec-2024

    Summary

    Official Symbol
    Ephrinprovided by FlyBase
    Official Full Name
    ephrinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040324
    Locus tag
    Dmel_CG1862
    See related
    AllianceGenome:FB:FBgn0040324
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1862; Dmel\CG1862; ephrin; lincRNA.922
    Summary
    Enables ephrin receptor binding activity. Involved in melanotic encapsulation of foreign target and nervous system development. Located in plasma membrane. Is expressed in several structures, including eye disc posterior to the morphogenetic furrow; larval central nervous system; presumptive embryonic/larval central nervous system; synaptic neuropil domain; and ventral ectoderm. Human ortholog(s) of this gene implicated in colon carcinoma; colorectal carcinoma; craniofrontonasal syndrome; dysostosis; and esophagus squamous cell carcinoma. Orthologous to several human genes including EFNB1 (ephrin B1); EFNB2 (ephrin B2); and EFNB3 (ephrin B3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Ephrin in Genome Data Viewer
    Location:
    102C5-102C6; 4-0 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (571755..580122)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (592381..600748)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene Purine-rich binding protein-alpha Neighboring gene NADH dehydrogenase (ubiquinone) 49 kDa subunit Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45199

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ephrin receptor binding  
    enables ephrin receptor binding PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance  
    involved_in axon guidance PubMed 
    involved_in ephrin receptor signaling pathway  
    involved_in melanotic encapsulation of foreign target PubMed 
    involved_in mushroom body development PubMed 
    involved_in peripheral nervous system development PubMed 
    Component Evidence Code Pubs
    located_in membrane  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    ephrin
    Names
    CG1862-PA
    CG1862-PB
    CG1862-PC
    Ephrin-PA
    Ephrin-PB
    Ephrin-PC
    dephrin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      571755..580122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166771.2 → NP_726584.1  ephrin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726584.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V4E1
      Related
      FBpp0088146
      Conserved Domains (2) summary
      cd02675
      Location:217 → 358
      Ephrin_ectodomain; Ectodomain of Ephrins
      pfam04987
      Location:557 → 622
      PigN; Phosphatidylinositolglycan class N (PIG-N)
    2. NM_166770.2 → NP_726583.1  ephrin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726583.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V4E1
      Related
      FBpp0088144
      Conserved Domains (2) summary
      cd02675
      Location:217 → 358
      Ephrin_ectodomain; Ectodomain of Ephrins
      pfam04987
      Location:557 → 622
      PigN; Phosphatidylinositolglycan class N (PIG-N)
    3. NM_143670.5 → NP_651927.1  ephrin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651927.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V4E1
      Related
      FBpp0088145
      Conserved Domains (2) summary
      cd02675
      Location:217 → 358
      Ephrin_ectodomain; Ectodomain of Ephrins
      pfam04987
      Location:557 → 622
      PigN; Phosphatidylinositolglycan class N (PIG-N)
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