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    nek1 NIMA-related kinase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 556002, updated on 9-Dec-2024

    Summary

    Official Symbol
    nek1provided by ZNC
    Official Full Name
    NIMA-related kinase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040730-1
    See related
    Ensembl:ENSDARG00000022350 AllianceGenome:ZFIN:ZDB-GENE-040730-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fc38c08; si:dkey-15j16.5; si:dkey-171k19.5
    Summary
    Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within cilium assembly and cranial skeletal system development. Predicted to be active in nucleus. Is expressed in forebrain; head; midbrain; and retina. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 24; asphyxiating thoracic dystrophy; orofaciodigital syndrome II; and short-rib thoracic dysplasia 6 with or without polydactyly. Orthologous to human NEK1 (NIMA related kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See nek1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (23668267..23714017)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (23769135..23814917)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene si:ch211-191d2.2 Neighboring gene carbonyl reductase 4 Neighboring gene SH3 domain containing ring finger 1 Neighboring gene si:dkey-15j16.3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cranial skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase Nek1
    Names
    DKEY-15J16.6
    NIMA (never in mitosis gene a)-related kinase 1
    XP_009292952.1
    XP_009292953.1
    XP_009292954.1
    XP_009292955.1
    XP_009292956.1
    XP_009292957.1
    XP_068071736.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      23668267..23714017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009294677.4XP_009292952.1  serine/threonine-protein kinase Nek1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B435
      Conserved Domains (2) summary
      smart00220
      Location:4258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08218
      Location:3258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1
    2. XM_009294679.4XP_009292954.1  serine/threonine-protein kinase Nek1 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AW79
      Conserved Domains (2) summary
      smart00220
      Location:4258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08218
      Location:3258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1
    3. XM_009294678.4XP_009292953.1  serine/threonine-protein kinase Nek1 isoform X2

      UniProtKB/TrEMBL
      A0A8M3ALI1
      Conserved Domains (2) summary
      smart00220
      Location:4258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08218
      Location:3258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1
    4. XM_009294681.4XP_009292956.1  serine/threonine-protein kinase Nek1 isoform X5

      UniProtKB/TrEMBL
      A0A8M3AKT9
      Conserved Domains (2) summary
      smart00220
      Location:4258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08218
      Location:3258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1
    5. XM_009294682.4XP_009292957.1  serine/threonine-protein kinase Nek1 isoform X6

      UniProtKB/TrEMBL
      A0A8M3B439
      Related
      ENSDARP00000030937.8, ENSDART00000035239.10
      Conserved Domains (2) summary
      smart00220
      Location:4258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08218
      Location:3258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1
    6. XM_068215635.1XP_068071736.1  serine/threonine-protein kinase Nek1 isoform X7

    7. XM_009294680.4XP_009292955.1  serine/threonine-protein kinase Nek1 isoform X4

      UniProtKB/TrEMBL
      A0A8M3AT70
      Conserved Domains (2) summary
      smart00220
      Location:4258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08218
      Location:3258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1