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Prickle1 prickle planar cell polarity protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315259, updated on 27-Nov-2024

Summary

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Official Symbol: Prickle1provided by RGD
Official Full Name: prickle planar cell polarity protein 1provided by RGD
Primary source: RGD:735090
See related: EnsemblRapid:ENSRNOG00000022772 AllianceGenome:RGD:735090
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rilp
Summary: Predicted to enable zinc ion binding activity. Involved in protein import into nucleus. Predicted to be located in cytosol and nuclear membrane. Predicted to be part of proteasome complex. Predicted to be active in several cellular components, including cell trailing edge; glutamatergic synapse; and postsynaptic density. Used to study temporal lobe epilepsy. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 1B. Orthologous to human PRICKLE1 (prickle planar cell polarity protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 84.3), Heart (RPKM 83.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Prickle1 in Genome Data Viewer

Location:: 7q35

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (126518587..126614581, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (124639142..124735027, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (134702964..134799437, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these findings suggest PRICKLE1 mutations contribute to ASD by disrupting the interaction with SYN1 and regulation of synaptic vesicles.
Title: PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders.
We conclude that the NRSE-NRSF system was implicated in HCN4 expression in cardiac myocytes.
Title: NRSF regulates the developmental and hypertrophic changes of HCN4 transcription in rat cardiac myocytes.
appears to serve as a nuclear receptor for REST/NRSF, REST4, and possibly other transcription factors
Title: REST/NRSF-interacting LIM domain protein, a putative nuclear translocation receptor.

Submit: New GeneRIF Correction

General gene information

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Markers

MARC_13855-13856:1032800061:3 (e-PCR)
- UniSTS:267581

BE114974 (e-PCR)
- UniSTS:261701

AW215793 (e-PCR)
- UniSTS:165961

RH143298 (e-PCR)
- UniSTS:232545

BE099414 (e-PCR)
- UniSTS:245660

RH138805 (e-PCR)
- UniSTS:220892

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Wnt signaling pathway, planar cell polarity pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway, planar cell polarity pathway	ISO Inferred from Sequence Orthology more info
involved_in animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in anterior visceral endoderm cell migration	IEA Inferred from Electronic Annotation more info
involved_in anterior visceral endoderm cell migration	ISO Inferred from Sequence Orthology more info
involved_in aorta development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within aorta development	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	IEA Inferred from Electronic Annotation more info
involved_in axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in basement membrane organization	IEA Inferred from Electronic Annotation more info
involved_in basement membrane organization	ISO Inferred from Sequence Orthology more info
involved_in bone mineralization	IEA Inferred from Electronic Annotation more info
involved_in bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell development	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium organization	ISO Inferred from Sequence Orthology more info
involved_in cornea development in camera-type eye	IEA Inferred from Electronic Annotation more info
involved_in cornea development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in coronary vasculature development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within coronary vasculature development	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton-dependent intracellular transport	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton-dependent intracellular transport	ISO Inferred from Sequence Orthology more info
involved_in dendrite development	IEA Inferred from Electronic Annotation more info
involved_in dendrite development	ISO Inferred from Sequence Orthology more info
involved_in embryonic brain development	IEA Inferred from Electronic Annotation more info
involved_in embryonic brain development	ISO Inferred from Sequence Orthology more info
involved_in embryonic digit morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic limb morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic nail plate morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic nail plate morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in establishment of bipolar cell polarity involved in cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in establishment of bipolar cell polarity involved in cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix assembly	IEA Inferred from Electronic Annotation more info
involved_in extracellular matrix assembly	ISO Inferred from Sequence Orthology more info
involved_in eyelid development in camera-type eye	IEA Inferred from Electronic Annotation more info
involved_in eyelid development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in face morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in face morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in focal adhesion disassembly	IEA Inferred from Electronic Annotation more info
involved_in focal adhesion disassembly	ISO Inferred from Sequence Orthology more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in limb development	ISO Inferred from Sequence Orthology more info
involved_in limb morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in maintenance of postsynaptic density structure	IEA Inferred from Electronic Annotation more info
involved_in maintenance of postsynaptic density structure	ISO Inferred from Sequence Orthology more info
involved_in mesenchyme development	IEA Inferred from Electronic Annotation more info
involved_in mesenchyme development	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism growth	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell myoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cardiac muscle cell myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in neural tube closure	IEA Inferred from Electronic Annotation more info
involved_in neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection extension	IEA Inferred from Electronic Annotation more info
involved_in neuron projection extension	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in outflow tract morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in polarized secretion of basement membrane proteins in epithelium	IEA Inferred from Electronic Annotation more info
involved_in polarized secretion of basement membrane proteins in epithelium	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in post-anal tail morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in post-anal tail morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in primitive streak formation	IEA Inferred from Electronic Annotation more info
involved_in primitive streak formation	ISO Inferred from Sequence Orthology more info
involved_in programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic density assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic density assembly	ISO Inferred from Sequence Orthology more info
involved_in renal tubule development	IEA Inferred from Electronic Annotation more info
involved_in renal tubule development	ISO Inferred from Sequence Orthology more info
involved_in response to electrical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to electrical stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in tear secretion	IEA Inferred from Electronic Annotation more info
involved_in tear secretion	ISO Inferred from Sequence Orthology more info
involved_in tissue development	ISO Inferred from Sequence Orthology more info
involved_in tissue homeostasis	IEA Inferred from Electronic Annotation more info
involved_in tissue homeostasis	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell trailing edge	IEA Inferred from Electronic Annotation more info
is_active_in cell trailing edge	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prickle-like protein 1

Names: REST/NRSF-interacting LIM domain protein 1; prickle homolog 1; prickle-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001434696.1 → NP_001421625.1 prickle-like protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007
NM_001434697.1 → NP_001421626.1 prickle-like protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007
NM_001434698.1 → NP_001421627.1 prickle-like protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007
NM_199396.1 → NP_955428.1 prickle-like protein 1

See identical proteins and their annotated locations for NP_955428.1

Status: PROVISIONAL

Source sequence(s)

CH474027

UniProtKB/Swiss-Prot

Q71QF9

UniProtKB/TrEMBL

A6K7T7, G3V8Z4

Related

ENSRNOP00000031476.4, ENSRNOT00000036750.7

Conserved Domains (4) summary

cd09418
Location:189 → 244

LIM2_Prickle; The second LIM domain of Prickle

cd09420
Location:249 → 307

LIM3_Prickle; The third LIM domain of Prickle

cd09483
Location:126 → 184

LIM1_Prickle_1; The first LIM domain of Prickle 1

cd09827
Location:22 → 118

PET_Prickle; The PET domain of Prickle

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

126518587..126614581 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006242213.5 → XP_006242275.1 prickle-like protein 1 isoform X1

UniProtKB/Swiss-Prot

Q71QF9

UniProtKB/TrEMBL

A6K7T7, G3V8Z4

Related

ENSRNOP00000098340.2, ENSRNOT00000120709.2

Conserved Domains (4) summary

cd09418
Location:189 → 244

LIM2_Prickle; The second LIM domain of Prickle

cd09420
Location:249 → 307

LIM3_Prickle; The third LIM domain of Prickle

cd09483
Location:126 → 184

LIM1_Prickle_1; The first LIM domain of Prickle 1

cd09827
Location:22 → 118

PET_Prickle; The PET domain of Prickle
XM_063263654.1 → XP_063119724.1 prickle-like protein 1 isoform X1

UniProtKB/TrEMBL

A6K7T7, G3V8Z4
XM_063263655.1 → XP_063119725.1 prickle-like protein 1 isoform X1

UniProtKB/TrEMBL

A6K7T7, G3V8Z4
XM_006242215.5 → XP_006242277.1 prickle-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_006242277.1

UniProtKB/Swiss-Prot

Q71QF9

UniProtKB/TrEMBL

A6K7T7, G3V8Z4

Conserved Domains (4) summary

cd09418
Location:189 → 244

LIM2_Prickle; The second LIM domain of Prickle

cd09420
Location:249 → 307

LIM3_Prickle; The third LIM domain of Prickle

cd09483
Location:126 → 184

LIM1_Prickle_1; The first LIM domain of Prickle 1

cd09827
Location:22 → 118

PET_Prickle; The PET domain of Prickle