PyK Pyruvate kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PyKprovided by FlyBase
Official Full Name: Pyruvate kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0267385
Locus tag: Dmel_CG7070
See related: AllianceGenome:FB:FBgn0267385
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: cg7070; CG7070; Dmel\CG7070; l(3)rQ178; l(3)r[Q178]; Pk; PK; PKM; Pyk; PYK
Summary: Enables pyruvate kinase activity. Involved in glucose homeostasis; pyruvate metabolic process; and response to sucrose. Located in P granule and cytosol. Is expressed in several structures, including adult brain; adult head; adult heart; germline cell; and muscle cell. Used to study disease of metabolism. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; pyruvate kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (pyruvate kinase L/R) and PKM (pyruvate kinase M1/2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 94A6-94A6; 3-74 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (22367536..22372746)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (18193258..18198468)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Metabolomic analysis of Drosophila melanogaster larvae lacking pyruvate kinase.
Title: Metabolomic analysis of Drosophila melanogaster larvae lacking pyruvate kinase.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables potassium ion binding	IEA Inferred from Electronic Annotation more info
enables pyruvate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyruvate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables pyruvate kinase activity	IEA Inferred from Electronic Annotation more info
enables pyruvate kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables pyruvate kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in canonical glycolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in pyruvate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyruvate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to sucrose	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in P granule	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: pyruvate kinase

Names: CG7070-PA; CG7070-PB; PyK-PA; PyK-PB; lethal (3) rQ178

NP_524448.3

EC 2.7.1.40

NP_732723.1

EC 2.7.1.40

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

22367536..22372746

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170004.2 → NP_732723.1 pyruvate kinase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732723.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O62619

Related

FBpp0083610

Conserved Domains (2) summary

cd00288
Location:25 → 511

Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

TIGR01064
Location:25 → 508

pyruv_kin; pyruvate kinase
NM_079724.3 → NP_524448.3 pyruvate kinase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524448.3

Status: REVIEWED

UniProtKB/Swiss-Prot

C3KGI0, O62619, Q86PE3, Q8MT14, Q9VD24

Related

FBpp0083611

Conserved Domains (2) summary

cd00288
Location:46 → 532

Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

TIGR01064
Location:46 → 529

pyruv_kin; pyruvate kinase