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    gish gilgamesh [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49701, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gishprovided by FlyBase
    Official Full Name
    gilgameshprovided by FlyBase
    Primary source
    FLYBASE:FBgn0250823
    Locus tag
    Dmel_CG6963
    See related
    AllianceGenome:FB:FBgn0250823
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.425; CG6963; CK1; CK1-gamma; CK1gamma; CK1[[gamma]]; CKI-related; CKIgamma; Dmel\CG6963; Gish; Hrr25; ms(3)89B; NEST:bs27c08; spider; Spider
    Summary
    Enables protein serine/threonine kinase activity. Involved in several processes, including olfactory learning; positive regulation of signal transduction; and sperm individualization. Located in cytoplasmic side of plasma membrane; nucleus; and sperm individualization complex. Is expressed in several structures, including adult brain; adult central complex; adult head; synaptic neuropil domain; and synaptic neuropil subdomain. Orthologous to several human genes including CSNK1G2 (casein kinase 1 gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See gish in Genome Data Viewer
    Location:
    89B9-89B12; 3-58 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16272452..16304768)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12098174..12130490)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene asunder Neighboring gene Mst89B Neighboring gene Maternal transcript 89Ba Neighboring gene Zinc/iron regulated transporter-related protein 89B Neighboring gene transfer RNA:Phenylalanine-GAA 1-8 Neighboring gene Sulfated

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the kinase domain of Gilgamesh from Drosophila melanogaster. Han N, et al. Acta Crystallogr F Struct Biol Commun, 2014 Apr. PMID 24699734, Free PMC Article
    2. [The role of Gilgamesh protein kinase in Drosophila melanogaster spermatogenesis]. Nerusheva OO, et al. Genetika, 2008 Sep. PMID 18846817
    3. Multiscale diffusion in the mitotic Drosophila melanogaster syncytial blastoderm. Daniels BR, et al. Proc Natl Acad Sci U S A, 2012 May 29. PMID 22592793, Free PMC Article
    4. The secretory membrane system in the Drosophila syncytial blastoderm embryo exists as functionally compartmentalized units around individual nuclei. Frescas D, et al. J Cell Biol, 2006 Apr 24. PMID 16636144, Free PMC Article
    5. A GFP trap study uncovers the functions of Gilgamesh protein kinase in Drosophila melanogaster spermatogenesis. Nerusheva OO, et al. Cell Biol Int, 2009 May. PMID 19269340

    See all (125) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gilgamesh (Gish)/CK1gamma regulates tissue homeostasis and aging in adult Drosophila midgut.
      Title: Gilgamesh (Gish)/CK1γ regulates tissue homeostasis and aging in adult Drosophila midgut.
    2. In this study, the authors have found that Drosophila gilgamesh (gish), which encodes a homologue of human CK1-gamma (casein kinase 1-gamma), is required intrinsically for germline stem cell maintenance.
      Title: Gilgamesh is required for the maintenance of germline stem cells in Drosophila testis.
    3. Data show that Hedgehog (Hh) stimulates the binding of Smoothened (Smo) to a plasma membrane-associated kinase Gilgamesh (Gish)/CK1gamma and that Gish fine-tunes Hh pathway activity by phosphorylating a Ser/Thr cluster of Smo carboxyl-terminal intracellular tail (C-tail).
      Title: Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase.
    4. The gish04895 mutation raises the threshold for evoked seizures in parabss1/+ flies.
      Title: Drosophila as a model for intractable epilepsy: gilgamesh suppresses seizures in para(bss1) heterozygote flies.
    5. Data show that Drosophila CK1-gamma/gilgamesh (gish) regulates the PCP-associated process of trichome formation through effects on Rab11-mediated vesicle recycling.
      Title: Drosophila CK1-γ, gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking.
    6. casein kinase 1 gamma 1 is a novel component of checkpoint responses that controls the interaction of a key checkpoint effector kinase with its cognate mediator protein
      Title: Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1.
    7. The Gilgamesh participates in a rutabaga-independent pathway for memory formation and accounts for some of the residual learning that occurs in rutabaga mutants in Drosophila.
      Title: Gilgamesh is required for rutabaga-independent olfactory learning in Drosophila.
    8. Data suggest that Gilgamesh is involved in spermatid internalization and displays a very close relation to the genes of yeast vesicular trafficking.
      Title: A GFP trap study uncovers the functions of Gilgamesh protein kinase in Drosophila melanogaster spermatogenesis.
    9. The role of Gilgamesh protein kinase in Drosophila melanogaster spermatogenesis
      Title: [The role of Gilgamesh protein kinase in Drosophila melanogaster spermatogenesis].
    10. Several CKI isoforms including CKIalpha and Gish/CKIgamma can phosphorylate the Wg coreceptor Arrow (Arr), which may account, at least in part, for their positive roles in the Wg pathway.
      Title: Regulation of wingless signaling by the CKI family in Drosophila limb development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of actin nucleation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of establishment of planar polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm individualization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm individualization complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gilgamesh
    Names
    CG6963-PA
    CG6963-PB
    CG6963-PC
    CG6963-PD
    CG6963-PE
    CG6963-PF
    CG6963-PG
    CG6963-PH
    CG6963-PI
    CG6963-PJ
    CG6963-PK
    CG6963-PL
    CG6963-PM
    CG6963-PN
    CG6963-PO
    CG6963-PP
    CKIg-like
    NEST:bs27c08
    casein kinase 1gamma
    gish-PA
    gish-PB
    gish-PC
    gish-PD
    gish-PE
    gish-PF
    gish-PG
    gish-PH
    gish-PI
    gish-PJ
    gish-PK
    gish-PL
    gish-PM
    gish-PN
    gish-PO
    gish-PP
    spider
    NP_001014626.1
    NP_001014627.2
    NP_001014628.1
    NP_001163628.1
    NP_001247137.1
    NP_001247138.1
    NP_001262624.1
    NP_001262625.1
    NP_001369018.1
    NP_001369019.1
    NP_001369020.1
    NP_524941.3
    NP_732123.1
    NP_732124.3
    NP_732125.2
    NP_788683.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16272452..16304768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169713.5 → NP_732125.2  gilgamesh, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732125.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BR9
      Related
      FBpp0082715
      Conserved Domains (3) summary
      smart00220
      Location:62 → 335
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14126
      Location:61 → 354
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:354 → 428
      CK1gamma_C; Casein kinase 1 gamma C terminal

    2. NM_001275695.1 → NP_001262624.1  gilgamesh, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262624.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHL4
      Conserved Domains (3) summary
      smart00220
      Location:62 → 335
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14126
      Location:61 → 354
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:354 → 428
      CK1gamma_C; Casein kinase 1 gamma C terminal

    3. NM_001275696.1 → NP_001262625.1  gilgamesh, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262625.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BR9
      Conserved Domains (3) summary
      smart00220
      Location:62 → 335
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14126
      Location:61 → 354
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:354 → 428
      CK1gamma_C; Casein kinase 1 gamma C terminal

    4. NM_001260208.2 → NP_001247137.1  gilgamesh, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247137.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K697
      Conserved Domains (3) summary
      smart00220
      Location:62 → 360
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14126
      Location:61 → 379
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:379 → 475
      CK1gamma_C; Casein kinase 1 gamma C terminal

    5. NM_001260209.2 → NP_001247138.1  gilgamesh, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247138.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7C4
      Conserved Domains (3) summary
      smart00220
      Location:62 → 357
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14126
      Location:61 → 376
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:376 → 450
      CK1gamma_C; Casein kinase 1 gamma C terminal

    6. NM_001170157.2 → NP_001163628.1  gilgamesh, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163628.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NK8
      Conserved Domains (3) summary
      smart00220
      Location:62 → 335
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14126
      Location:61 → 354
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:354 → 428
      CK1gamma_C; Casein kinase 1 gamma C terminal

    7. NM_169712.4 → NP_732124.3  gilgamesh, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732124.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BR9
      Conserved Domains (3) summary
      smart00220
      Location:62 → 335
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14126
      Location:61 → 354
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:354 → 428
      CK1gamma_C; Casein kinase 1 gamma C terminal

    8. NM_176506.4 → NP_788683.1  gilgamesh, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788683.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59DW8
      Related
      FBpp0082719
      Conserved Domains (3) summary
      smart00220
      Location:62 → 330
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14126
      Location:61 → 349
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:349 → 423
      CK1gamma_C; Casein kinase 1 gamma C terminal

    9. NM_001014626.4 → NP_001014626.1  gilgamesh, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014626.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BR9
      Conserved Domains (3) summary
      smart00220
      Location:62 → 335
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14126
      Location:61 → 354
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:354 → 428
      CK1gamma_C; Casein kinase 1 gamma C terminal

    10. NM_001014628.3 → NP_001014628.1  gilgamesh, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014628.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IHB0
      Conserved Domains (2) summary
      smart00220
      Location:62 → 335
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14126
      Location:61 → 354
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma

    11. NM_001382189.1 → NP_001369018.1  gilgamesh, isoform N [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EFT7
      Conserved Domains (2) summary
      cd14126
      Location:20 → 308
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:337 → 419
      CK1gamma_C; Casein kinase 1 gamma C terminal

    12. NM_169711.5 → NP_732123.1  gilgamesh, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732123.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEX2
      Related
      FBpp0082717
      Conserved Domains (2) summary
      cd14126
      Location:20 → 308
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:308 → 382
      CK1gamma_C; Casein kinase 1 gamma C terminal

    13. NM_080202.6 → NP_524941.3  gilgamesh, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524941.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INB6
      Related
      FBpp0082718
      Conserved Domains (2) summary
      cd14126
      Location:20 → 313
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:313 → 387
      CK1gamma_C; Casein kinase 1 gamma C terminal

    14. NM_001382190.1 → NP_001369019.1  gilgamesh, isoform O [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EGC1
      Conserved Domains (2) summary
      cd14126
      Location:20 → 308
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:308 → 370
      CK1gamma_C; Casein kinase 1 gamma C terminal

    15. NM_001382191.1 → NP_001369020.1  gilgamesh, isoform P [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EFD0
      Conserved Domains (1) summary
      cd14126
      Location:20 → 308
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma

    16. NM_001014627.2 → NP_001014627.2  gilgamesh, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014627.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4AB31
      Conserved Domains (3) summary
      smart00220
      Location:70 → 343
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14126
      Location:69 → 362
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:362 → 436
      CK1gamma_C; Casein kinase 1 gamma C terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K697 A0A0B4K697
    A0A0B4K7C4 A0A0B4K7C4
    A0A0B4KHL4 A0A0B4KHL4
    A0A6H2EFD0 A0A6H2EFD0
    A0A6H2EFT7 A0A6H2EFT7
    A0A6H2EGC1 A0A6H2EGC1
    Q4AB31 Q4AB31
    Q59DW8 Q59DW8
    Q86BR9 Q86BR9
    Q86NK8 Q86NK8
    Q8IHB0 Q8IHB0
    Q8INB6 Q8INB6
    Q9VEX2 Q9VEX2

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