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    PH4alphaEFB prolyl 4-hydroxylase subunit alpha-1 [ Apis mellifera (honey bee) ]

    Gene ID: 408862, updated on 23-Nov-2024

    Summary

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    Gene symbol
    PH4alphaEFB
    Gene description
    prolyl 4-hydroxylase subunit alpha-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Apis mellifera
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Anthophila; Apidae; Apis
    Also known as
    GB41280
    Orthologs
    fruit fly all
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    Genomic context

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    See PH4alphaEFB in Genome Data Viewer
    Location:
    chromosome: LG5
    Exon count:
    17
    Annotation release Status Assembly LG Location
    104 current Amel_HAv3.1 (GCF_003254395.2) LG5 NC_037642.1 (12233711..12557089)
    103 previous assembly Amel_4.5 (GCF_000002195.4) LG5 NC_007074.3 (12504896..12874838)

    Linkage Group LG5 - NC_037642.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 135 Neighboring gene pyrroline-5-carboxylate reductase 2 Neighboring gene transfer RNA tyrosine (anticodon GUA) Neighboring gene uncharacterized LOC102656631 Neighboring gene uncharacterized LOC107964433 Neighboring gene uncharacterized LOC107964432 Neighboring gene uncharacterized LOC113218761 Neighboring gene probable helicase with zinc finger domain Neighboring gene uncharacterized LOC102654095 Neighboring gene uncharacterized LOC102656927 Neighboring gene DBB domain-containing protein stumps Neighboring gene DnaJ domain-containing protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential expression of endogenous plant cell wall degrading enzyme genes in the stick insect (Phasmatodea) midgut. Shelomi M, et al. BMC Genomics, 2014 Oct 21. PMID 25331961, Free PMC Article
    2. Insights into social insects from the genome of the honeybee Apis mellifera. Honeybee Genome Sequencing Consortium. Nature, 2006 Oct 26. PMID 17073008, Free PMC Article
    3. ProtoBee: hierarchical classification and annotation of the honey bee proteome. Kaplan N, et al. Genome Res, 2006 Nov. PMID 17065614, Free PMC Article
    4. Finding the missing honey bee genes: lessons learned from a genome upgrade. Elsik CG, et al. BMC Genomics, 2014 Jan 30. PMID 24479613, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables procollagen-proline 4-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prolyl 4-hydroxylase subunit alpha-1; prolyl 4-hydroxylase subunit alpha-2
    Names
    prolyl-4-hydroxylase-alpha EFB
    XP_016767671.2
    XP_026296347.1
    XP_026296348.1
    XP_026296349.1
    XP_026296350.1
    XP_026296351.1
    XP_026296352.1
    XP_026296353.1
    XP_026296354.1
    XP_026296355.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001434656.1 → NP_001421585.1  prolyl 4-hydroxylase subunit alpha-1 precursor

      Status: VALIDATED

      Source sequence(s)
      QIUM02000019

    RefSeqs of Annotated Genomes: Apis mellifera Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Amel_HAv3.1 Primary Assembly

    Genomic

    1. NC_037642.1 Reference Amel_HAv3.1 Primary Assembly

      Range
      12233711..12557089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016912182.2 → XP_016767671.2  prolyl 4-hydroxylase subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0A7M7M0K9, A0A8B7KKE1
      Conserved Domains (3) summary
      cd05468
      Location:14 → 77
      pVHL; von Hippel-Landau (pVHL) tumor suppressor protein
      smart00702
      Location:468 → 641
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:138 → 269
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    2. XM_026440566.1 → XP_026296351.1  prolyl 4-hydroxylase subunit alpha-1 isoform X4

      UniProtKB/TrEMBL
      A0A7M7L8Y7, A0A7M7MGR2, A0A8B8GX94, A0A8B8GZS3
      Conserved Domains (2) summary
      smart00702
      Location:366 → 539
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:36 → 167
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    3. XM_026440563.1 → XP_026296348.1  prolyl 4-hydroxylase subunit alpha-1 isoform X3

      UniProtKB/TrEMBL
      A0A7M7L371, A0A8B8GYL6
      Conserved Domains (2) summary
      smart00702
      Location:416 → 589
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:86 → 217
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    4. XM_026440565.1 → XP_026296350.1  prolyl 4-hydroxylase subunit alpha-1 isoform X4

      UniProtKB/TrEMBL
      A0A7M7L8Y7, A0A7M7MGR2, A0A8B8GX94, A0A8B8GZS3
      Conserved Domains (2) summary
      smart00702
      Location:366 → 539
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:36 → 167
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    5. XM_026440567.1 → XP_026296352.1  prolyl 4-hydroxylase subunit alpha-1 isoform X4

      UniProtKB/TrEMBL
      A0A7M7L8Y7, A0A7M7MGR2, A0A8B8GX94, A0A8B8GZS3
      Conserved Domains (2) summary
      smart00702
      Location:366 → 539
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:36 → 167
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    6. XM_026440564.1 → XP_026296349.1  prolyl 4-hydroxylase subunit alpha-1 isoform X4

      UniProtKB/TrEMBL
      A0A7M7L8Y7, A0A7M7MGR2, A0A8B8GX94, A0A8B8GZS3
      Conserved Domains (2) summary
      smart00702
      Location:366 → 539
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:36 → 167
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    7. XM_026440568.1 → XP_026296353.1  prolyl 4-hydroxylase subunit alpha-1 isoform X4

      UniProtKB/TrEMBL
      A0A7M7L8Y7, A0A7M7MGR2, A0A8B8GX94, A0A8B8GZS3
      Conserved Domains (2) summary
      smart00702
      Location:366 → 539
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:36 → 167
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    8. XM_026440570.1 → XP_026296355.1  prolyl 4-hydroxylase subunit alpha-1 isoform X4

      UniProtKB/TrEMBL
      A0A7M7L8Y7, A0A7M7MGR2, A0A8B8GX94, A0A8B8GZS3
      Conserved Domains (2) summary
      smart00702
      Location:366 → 539
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:36 → 167
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    9. XM_026440562.1 → XP_026296347.1  prolyl 4-hydroxylase subunit alpha-1 isoform X2

      UniProtKB/TrEMBL
      A0A7M7L1R1, A0A8B8GXD2
      Conserved Domains (2) summary
      smart00702
      Location:439 → 612
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:109 → 240
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    10. XM_026440569.1 → XP_026296354.1  prolyl 4-hydroxylase subunit alpha-2 isoform X5

      UniProtKB/TrEMBL
      A0A7M7L503, A0A8B8GZS7
      Conserved Domains (2) summary
      smart00702
      Location:309 → 482
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:15 → 110
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version

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